2-(2-HYDROXYETHYL)QUINOLINE
- Product Name
- 2-(2-HYDROXYETHYL)QUINOLINE
- CAS No.
- 1011-50-3
- Chemical Name
- 2-(2-HYDROXYETHYL)QUINOLINE
- Synonyms
- EINECS 213-784-6;2-Quinolineethanol;quinoline-2-ethanol;2-(2-quinolyl)ethanol;2-(2-Quinolinyl)ethanol;2-(2-HYDROXYETHYL)QUINOLINE
- CBNumber
- CB3131354
- Molecular Formula
- C11H11NO
- Formula Weight
- 173.21
- MOL File
- 1011-50-3.mol
2-(2-HYDROXYETHYL)QUINOLINE Property
- Melting point:
- 103-104℃
- Boiling point:
- 303.86°C (rough estimate)
- Density
- 1.177
- refractive index
- 1.4950 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.84±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C11H11NO/c13-8-7-10-6-5-9-3-1-2-4-11(9)12-10/h1-6,13H,7-8H2
- InChIKey
- VPDAGUVEZGEHJJ-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2)C=CC=1CCO
- EPA Substance Registry System
- 2-Quinolineethanol (1011-50-3)
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-D0103
- Product name
- 2-(2-Hydroxyethyl)quinoline
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- OR906914
- Product name
- 2-(2-Hydroxyethyl)quinoline
- Purity
- 95%
- Packaging
- 1g
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 073309
- Product name
- 2-(2-Hydroxyethyl)quinoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $445
- Updated
- 2021/12/16
- Product number
- OR906914
- Product name
- 2-(2-Hydroxyethyl)quinoline
- Purity
- 95%
- Packaging
- 5g
- Price
- $655
- Updated
- 2021/12/16
- Product number
- 073309
- Product name
- 2-(2-Hydroxyethyl)quinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $958
- Updated
- 2021/12/16
2-(2-HYDROXYETHYL)QUINOLINE Chemical Properties,Usage,Production
Synthesis
5100-57-2
1011-50-3
General procedure for the synthesis of 2-(2-hydroxymethyl)quinoline from ethyl 2-quinolineacetate: ethyl 2-quinolineacetate (8.6 g, 42.8 mmol) was dissolved in ether (400 mL) and cooled to -78 °C. At -78 °C, lithium aluminum hydride (1.63 g, 42.8 mmol) was added in batches. After maintaining -78 °C for 2 hours of stirring, the temperature was slowly increased to 0 °C and stirring was continued at 0 °C for 4 hours, followed by stirring at room temperature overnight. Upon completion of the reaction, the mixture was cooled to 0 °C and a small amount of methanol was added to quench unreacted lithium aluminum hydride, followed by sodium sulfate decahydrate (43 g). After stirring for 1 h at room temperature, the reaction mixture was filtered, the solid residue was washed with chloroform, and the filtrates were combined and concentrated. Purification by silica gel column chromatography (eluent ratio 2:1 ethyl acetate-hexane) afforded 0.46 g (53% yield) of 2-(2-hydroxymethyl)quinoline. The product was confirmed by 13C NMR (101 MHz, chloroform-D) with chemical shifts of δ 161.53, 147.23, 137.04, 130.01, 128.74, 127.79, 127.03, 126.39, 122.09, 61.60, 39.52 ppm; mass spectrometry (AP/CI) showed the molecular ion peak m/z 174.2 (M + H)+.
References
[1] Patent: WO2008/20302, 2008, A2. Location in patent: Page/Page column 26
[2] Patent: WO2014/140184, 2014, A1. Location in patent: Page/Page column 71-72
[3] Monatshefte fuer Chemie, 1952, vol. 83, p. 915,922
2-(2-HYDROXYETHYL)QUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(2-HYDROXYETHYL)QUINOLINE manufacturers
- Product
- 2-(2-HYDROXYETHYL)QUINOLINE 1011-50-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-08-02
- Product
- 2-(2-HYDROXYETHYL)QUINOLINE 1011-50-3
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09