bleomycin A6
- Product Name
- bleomycin A6
- CAS No.
- 37293-17-7
- Chemical Name
- bleomycin A6
- Synonyms
- Boanmycin;bleomycin A6;Pingyangmycin A6;Zhengguangmycin A6;N1-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]bleomycinamide;Bleomycinamide, N1-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-
- CBNumber
- CB31315485
- Molecular Formula
- C60H96N20O21S2
- Formula Weight
- 1497.67
- MOL File
- 37293-17-7.mol
bleomycin A6 Property
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 10.84±0.46(Predicted)
Safety
- Toxicity
- LD50 intramuscular in mouse: 70530ug/kg
N-Bromosuccinimide Price
- Product number
- API0013275
- Product name
- BLEOMYCIN A6
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.16
- Updated
- 2021/12/16
bleomycin A6 Chemical Properties,Usage,Production
Uses
Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].
in vivo
Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks) can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells[1].
| Animal Model: | BALB/c nude mice with HT-29 or Hce-8693 cells[1] |
| Dosage: | 10 or 15 mg/kg |
| Administration: | Intraperitoneal injection; twice a week; 5 weeks |
| Result: | Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model. |
| Animal Model: | BALB/c nude mice with CT-26 cells[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intramuscular injection; every second day; 10 times |
| Result: | Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%. |
References
[1] Y C Deng, et al. Activity of boanmycin against colorectal cancer. World J Gastroenterol. 2001 Feb;7(1):93-7. DOI:10.3748/wjg.v7.i1.93
[2] Hao Tang, et al. Effect of boanmycin on apoptosis and cell cycle of human esophageal cancer(Eca-109) cells]. Ai Zheng. 2002 Aug;21(8):855-9. PMID:12478892
[3] Peng Chen, et al. The chemotherapeutic drug boanmycin induces cell senescence and senescence-associated secretory phenotype factors, thus acquiring the potential to remodel the tumor microenvironment. Anticancer Drugs. 2016 Feb;27(2):84-8. DOI:10.1097/CAD.0000000000000304
bleomycin A6 Preparation Products And Raw materials
Raw materials
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