ChemicalBook > CAS DataBase List > YM 114
YM 114
- Product Name
- YM 114
- CAS No.
- 153608-99-2
- Chemical Name
- YM 114
- Synonyms
- YM 114;Kae 393
- CBNumber
- CB31317151
- Molecular Formula
- C16H18ClN3O
- Formula Weight
- 303.79
- MOL File
- 153608-99-2.mol
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- CHM1038454
- Product name
- YM 114
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.19
- Updated
- 2021/12/16
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YM 114 Chemical Properties,Usage,Production
Description
YM 114 is a 5-HT(3) receptor anatagonist.
Uses
YM114 (KAE-393) is a highly potent and selective (5-HT)3-receptor antagonist that does not affect Veratridine (HY-N6691)- or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358)-induced Bezold-Jarisch reflex, which originates from (5-HT)3-receptor located on the endings of vagal afferent nerves in the heart[1].
References
[1] Yamano M, et al. Characteristics of inhibitory effects of serotonin (5-HT)3-receptor antagonists, YM060 and YM114 (KAE-393), on the von Bezold-Jarisch reflex induced by 2-Methyl-5-HT, veratridine and electrical stimulation of vagus nerves in anesthetized rats. Jpn J Pharmacol. 1995 Dec;69(4):351-6. DOI:10.1254/jjp.69.351
YM 114 Preparation Products And Raw materials
Raw materials
Preparation Products
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YM 114 Suppliers
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YM 114