DEXTROMETHORPHAN HYDROBROMIDE
- Product Name
- DEXTROMETHORPHAN HYDROBROMIDE
- CAS No.
- 125-69-9
- Chemical Name
- DEXTROMETHORPHAN HYDROBROMIDE
- Synonyms
- DEXTROMETHORPHAN HBR;RACEMETHORPHAN;Dextro;Delsym;ROMILAR;Sisaal;medicon;tusilan;Tussade;antussan
- CBNumber
- CB3131945
- Molecular Formula
- C18H26BrNO
- Formula Weight
- 352.31
- MOL File
- 125-69-9.mol
DEXTROMETHORPHAN HYDROBROMIDE Property
- Melting point:
- 125-127℃
- alpha
- D20 +27.6° (c = 1.5 in water)
- pka
- pKa 8.83(50% aq EtOH) (Uncertain)
- form
- Solid
- Water Solubility
- Soluble in water (40 mM), and alcohol (1:10).
- EPA Substance Registry System
- Morphinan, 3-methoxy-17-methyl-, hydrobromide (1:1),(9.alpha.,13.alpha.,14.alpha.)- (125-69-9)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 36/37
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- cat,LD50,intravenous,19800ug/kg (19.8mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEASENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE,Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.
N-Bromosuccinimide Price
- Product number
- J61732
- Product name
- Dextromethorphan hydrobromide
- Packaging
- 5g
- Price
- $110
- Updated
- 2023/06/20
- Product number
- J61732
- Product name
- Dextromethorphan hydrobromide
- Packaging
- 10g
- Price
- $217
- Updated
- 2023/06/20
- Product number
- J61732
- Product name
- Dextromethorphan hydrobromide
- Packaging
- 50g
- Price
- $784
- Updated
- 2023/06/20
- Product number
- DCAPI1431
- Product name
- Dextromethorphan hydrobromide
- Purity
- >99%
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
DEXTROMETHORPHAN HYDROBROMIDE Chemical Properties,Usage,Production
Originator
Symptom 1 ,Parke Davis,US,1977
Uses
It is used as a potentially useful NMDA receptor agonist. it is usually used as central nervous antitussive, cough suppressant. This is one of the most popular ingredients in over-the-counter cold and cough medications. Dextromethorphan hydrobromide may be added to other preparations to help treat pain and a variety of other disturbances as well. It is used as a pharmaceutical raw material.
Uses
relieving cough
Uses
Cough and cold preparations, Antitussives, OTC cough medicine
Manufacturing Process
The methylation of 51.4 parts by weight of D,L-3-hydroxy-N-methylmorphinan is carried out with a methylating solution obtained from 51.5 parts
by weight of phenyl-trimethylammonium-chloride. The D,L-3-methoxy-Nmethyl-morphinan is isolated in the form of its hydrobromide, which melts
with 1 mol of water at 92°-94°C,without water at 239°-240°C. The base
isolated from the aqueous solution by means of sodium carbonate melts at
81°-83°C.
27.1 parts by weight of D,L-3-methoxy-N-methyl-morphinan base are
dissolved with 15.0 parts by weight of D-tartaric acid in 150 parts by volume
of hot alcohol. The solution is cooled and seeded with (+)-3-methoxy-Nmethyl-morphinan-tartrate.The (+)-form which is difficultly soluble in alcohol
separates, is filtered by suction and washed with a little alcohol.
[The (-)-form may be crystallized from the residue obtained by concentrating
the mother liquor, separating therefrom as much as possible of the (+)-form
and adding acetone].
The (+)-3-methoxy-N-methyl-morphinan-tartrate melts with 1 mol of water at
195°-196°C [α]D20 =+30.6° (c = 1.5 in water). The (+) base melting at
108°-109°C may be obtained from the tartrate by means of sodium
carbonate. The corresponding hydrobromide melts at 122°-124°C [α]D20
=+27.6° (c = 1.5 in water).
brand name
Benylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).
Therapeutic Function
Antitussive