4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE

Uses

Product Name: 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
CAS No.: 54757-47-0
Chemical Name: 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
Synonyms: CHEMBRDG-BB 5229800;Acitretin Impurity 2;4-(4-Methoxy-2,3,6-trimethylphenyl);4-(4-Methoxy-2,3,6-trimethylphenyl)-3-en-2-one;4-(4-Methoxy-2,3,6-trimethyphenyl)-but-3-en-2-one;4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE;3-Buten-2-one, 4-(4-methoxy-2,3,6-trimethylphenyl)-;4-(4'-methoxy-2',3',6'-trimethylphenyl)-but-3-ene-2-one;(E)-4-(4-METHOXY-2,3,6-TRIMETHYL-PHENYL)-BUT-3-EN-2-ONE
CBNumber: CB3132003
Molecular Formula: C14H18O2
Formula Weight: 218.29
MOL File: 54757-47-0.mol

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4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE Property

Melting point:: 64-66 °C
Boiling point:: 358.7±37.0 °C(Predicted)
Density: 1.006±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
InChI: InChI=1S/C14H18O2/c1-9-8-14(16-5)12(4)11(3)13(9)7-6-10(2)15/h6-8H,1-5H3
InChIKey: NMRRLIHKRCVLLQ-UHFFFAOYSA-N
SMILES: CC(=O)C=CC1=C(C)C=C(OC)C(C)=C1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M332495
Product name: 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 7959AB
Product name: 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one
Packaging: 100mg
Price: $29
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0165746
Product name: 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
Purity: 98.00%
Packaging: 5G
Price: $1443.75
Updated: 2021/12/16

Alichem

Product number: 54757470
Product name: 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one
Packaging: 5g
Price: $189
Updated: 2021/12/16

Crysdot

Product number: CD12062298
Product name: 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one
Purity: 97%
Packaging: 10g
Price: $277
Updated: 2021/12/16

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4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE Chemical Properties,Usage,Production

Uses

4-(4-Methoxy-2,3,6-trimethylphenyl)-3E-buten-2-one is a ketone derivative that can be used as a pharmaceutical intermediate.

Synthesis

54344-92-2

67-64-1

54757-47-0

General procedure for the synthesis of 4-(4-methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one from 4-methoxy-2,3,6-trimethylbenzaldehyde and acetone: Acetone (6000 mL) was added to 4-methoxy-2,3,6-trimethylbenzaldehyde (500.3 g) and the mixture was stirred at 20-30 °C. An aqueous sodium hydroxide solution (134.8 g NaOH dissolved in 500 mL of water) was added gradually and the reaction mixture was heated to 45-50 °C with continuous stirring. The progress of the reaction was monitored by HPLC and upon completion of the reaction, the reaction mixture was cooled and the pH was adjusted with acetic acid to 4.5-5.5. Subsequently, acetone was removed by distillation, cyclohexane was added to the residue, the organic layer was washed with water, the organic layer was separated and concentrated to afford the target product, 4-(4-methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one (Formula II). Yield: 80-84%.

References

[1] Pharmaceutical Research, 1995, vol. 12, # 7, p. 983 - 992
[2] Patent: WO2016/42573, 2016, A1. Location in patent: Page/Page column 8
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2010, vol. 185, # 3, p. 501 - 508

4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE Suppliers

China 54 India 2 United Kingdom 3 United States 9 Global 68

Wuhan xinyangruihe Chemical Technology Co., Ltd.

Tel: 027-83855316; 18171155316
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Henan Alfa Chemical Co., Ltd

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View Lastest Price from 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE 54757-47-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Career Henan Chemical Co

Product: 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE 54757-47-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-07

54757-47-0, 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONERelated Search:

4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE 2,6-DIMETHYLSTYRENE 4-METHOXY-2-METHYL-1-VINYL-BENZENE 3,4,5-TRIMETHYLPHENOL

4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE

(E)-4-(4-METHOXY-2,3,6-TRIMETHYL-PHENYL)-BUT-3-EN-2-ONE

CHEMBRDG-BB 5229800

4-(4-Methoxy-2,3,6-trimethylphenyl)

4-(4'-methoxy-2',3',6'-trimethylphenyl)-but-3-ene-2-one

Acitretin Impurity 2

3-Buten-2-one, 4-(4-methoxy-2,3,6-trimethylphenyl)-

4-(4-Methoxy-2,3,6-trimethyphenyl)-but-3-en-2-one

4-(4-Methoxy-2,3,6-trimethylphenyl)-3-en-2-one

54757-47-0

C14H18O2