AOH1996

Product Name: AOH1996
CAS No.: 2089314-64-5
Chemical Name: AOH1996
Synonyms: AOH1196;N-[2-[[2-(3-methoxyphenoxy)phenyl]amino]-2-oxoethyl]-;N-(2-((2-(3-methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide;N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide;N-(2-((2-(3-Methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide , AOH1996;AOH1996/N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide;1-Naphthalenecarboxamide, N-[2-[[2-(3-methoxyphenoxy)phenyl]amino]-2-oxoethyl]-
CBNumber: CB313247879
Molecular Formula: C26H22N2O4
Formula Weight: 426.46
MOL File: 2089314-64-5.mol

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AOH1996 Property

Boiling point:: 703.9±50.0 °C(Predicted)
Density: 1.269±0.06 g/cm3(Predicted)
solubility: Chloroform: Soluble
Ethanol: Soluble
Methanol: Soluble
pka: 12.87±0.70(Predicted)
InChI: InChI=1S/C26H22N2O4/c1-31-19-10-7-11-20(16-19)32-24-15-5-4-14-23(24)28-25(29)17-27-26(30)22-13-6-9-18-8-2-3-12-21(18)22/h2-16H,17H2,1H3,(H,27,30)(H,28,29)
InChIKey: HDMONPHKMIZXDH-UHFFFAOYSA-N
SMILES: C1(C(NCC(NC2=CC=CC=C2OC2=CC=CC(OC)=C2)=O)=O)=C2C(C=CC=C2)=CC=C1

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Hazard and Precautionary Statements (GHS)

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AOH1996 Chemical Properties,Usage,Production

Description

AOH1996 is an inhibitor of proliferating cell nuclear antigen (PCNA).1 It binds to PCNA in a thermal shift assay. AOH1996 (500 nM) induces apoptosis in SK-N-DZ neuroblastoma cells but not 7SMOO32 normal neural crest stem cells. It induces DNA damage in SK-N-AS neuroblastoma cells expressing wild-type DNA-directed RNA polymerase II subunit RPB1 but not in SK-N-AS cells expressing RPB1Y418A. AOH1996 (40 mg/kg) decreases tumor volume in SK-N-BE(2)-C neuroblastoma, MDA-MB-468 breast cancer, and NCI H82 small cell lung cancer mouse xenograft models.WARNING This product is not for human or veterinary use.

References

[1] LONG GU . Small molecule targeting of transcription-replication conflict for selective chemotherapy[J]. Cell Chemical Biology, 2023, 30 10: Pages 1235-1247.e6. DOI: 10.1016/j.chembiol.2023.07.001

AOH1996 Preparation Products And Raw materials

Raw materials

Preparation Products

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AOH1996 Suppliers

China 88 United States 2 Global 90

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 6001
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Changzhou Borl Biotechnology Co.,LTD

Tel: 13606124132;13656121842
Email: luyan0021@163.com
Country: China
ProdList: 242
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Zibo Biopolar Rongchuang Pharmaceutical Co. Ltd.

Tel: 0533-6092686 13371592196
Email: ddliu@bio-polar.cn
Country: China
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Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
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SuZhou GoodChemTech Co., Ltd

Tel: 18136139868; 18136139868
Email: jinlun@goodchemtech.cn
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Shanghai Hongboshangyi Pharmaceutical Technology Co. , Ltd.

Tel: 15927323052
Email: shenqianyan@prssh.com
Country: China
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Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
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Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3921
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View Lastest Price from AOH1996 manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: AOH1996 2089314-64-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200KG
Release date: 2024-04-25

2089314-64-5, AOH1996Related Search:

1-Naphthalenecarboxamide, N-[2-[[2-(3-methoxyphenoxy)phenyl]amino]-2-oxoethyl]-

N-(2-((2-(3-methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide

AOH1996/N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide

AOH1196

N-[2-[[2-(3-methoxyphenoxy)phenyl]amino]-2-oxoethyl]-

N-(2-((2-(3-Methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide , AOH1996

N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide

2089314-64-5

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