BIBN 4096BS

Product Name: BIBN 4096BS
CAS No.: 204697-65-4
Chemical Name: BIBN 4096BS
Synonyms: BIBN-4096;Olcegepant;BIBN 4096BS;Olcegepant（ BIBN-4096）;Olcegepant, 10 mM in DMSO;BIBN 4096BS API Olcegepant;Olcegepant, CGRP antagonist;Olcegepant/BIBN-4096/BIBN 4096BS;inhibit,BIBN4096,Olcegepant,CGRP Receptor,Calcitonin gene-related peptide receptor,BIBN 4096,Inhibitor;1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine
CBNumber: CB31346269
Molecular Formula: C38H47Br2N9O5
Formula Weight: 869.65
MOL File: 204697-65-4.mol

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BIBN 4096BS Property

Boiling point:: 1091.9±65.0 °C(Predicted)
Density: 1.497
storage temp.: Store at -20°C
solubility: ≥87 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form: Powder
pka: 6.80±0.25(Predicted)
color: White to off-white
InChIKey: ITIXDWVDFFXNEG-UHFFFAOYSA-N
SMILES: Brc1c(c(cc(c1)CC(NC(=O)N4CCC(CC4)N5Cc6c(cccc6)NC5=O)C(=O)NC(CCCCN)C(=O)N2CCN(CC2)c3ccncc3)Br)O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2426
Product name: BIBN4096BS
Purity: ≥95% (HPLC)
Packaging: 5 mg
Price: $125.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2426
Product name: BIBN4096BS
Purity: ≥95% (HPLC)
Packaging: 25 mg
Price: $528
Updated: 2025/07/31

Tocris

Product number: 4561
Product name: BIBN4096
Purity: ≥95%(HPLC)
Packaging: 10
Price: $338
Updated: 2021/12/16

TRC

Product number: O516000
Product name: Olcegepant
Packaging: 1mg
Price: $235
Updated: 2021/12/16

Usbiological

Product number: 018736
Product name: Olcegepant
Packaging: 10mg
Price: $566
Updated: 2021/12/16

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BIBN 4096BS Chemical Properties,Usage,Production

Uses

Olcegepant is a potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist. Olcegepant displays high affinity for human CGRP receptors and exhibits no significant affinity for 75 other receptors. Olcegepant may a be viable option for the treatment of acute migraines.

Biological Activity

BIBN4096BS (Olcegepant) is a potent calcitonin gene-related peptide (CGRP) receptor antagonist with higher affinity/potency toward human over r at & mouse receptor (human/r at Ki = 14.4 pM/3.4 nM by binding assay; human/mouse Kb = 8 pM//7.711 nM by cellular cAMP assay). BIBN4096BS inhibits facial blood flow by electrical stimulation of marmoset monkey trigeminal ganglion (IC50 = 3 μg/kg i.v.) without any intrinsic cardiovascular effects. Studies using anaesthetized rats reveals th at BIBN4096BS antagonism against trigeminal nociceptive stimulation by capsaicin is limited to the spinal trigeminal nucleus, but not trigeminal ganglion. Also widely employed for in vivo studies in mice.

in vivo

Olcegepant (BIBN4096BS) in doses between 1 and 30 μg/kg (i.v.) inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys^[2]. Pre-treatment with Olcegepant (900 μg/kg) inhibits the capsaicin-induced expression of Fos throughout the spinal trigeminal nucleus by 57%. In contrast, the expression of phosphorylated extracellular signal-regulated kinase in the trigeminal ganglion is not changed by Olcegepant pre-treatment^[4]. Olcegepant (0.3 to 0.9 mg/kg, i.v.) markedly reduces mechanical allodynia in CCI-ION rats. Olcegepant (0.6 mg/kg, i.v.) significantly reduces the number of c-Fos immunolabeled cells in spinal nucleus of the trigeminal nerve and upregulation of ATF3 transcript (a marker of neuron injury) but not that of interleukin-6 in trigeminal ganglion of CCI-ION rats^[5].

target

CGRP1

storage

Store at -20°C

BIBN 4096BS Preparation Products And Raw materials

Raw materials

Preparation Products

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BIBN 4096BS Suppliers

Canada 2 China 80 India 1 United Kingdom 1 United States 13 Global 97

J & K SCIENTIFIC LTD.

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LETOPHARM LIMITED

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Shanghai Lollane Biological Technology Co.,Ltd.

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SPIRO PHARMA

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View Lastest Price from BIBN 4096BS manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Olcegepant 204697-65-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Olcegepant 204697-65-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

204697-65-4, BIBN 4096BSRelated Search:

Sulfanilamide 5-DIMETHYLAMINO-1-NAPHTHALENESULFONIC ACID HYDRATE

BIBN 4096BS

BIBN-4096

N-[2-[5-Amino-1(S)-[4-(4-pyridinyl)piperazin-1-ylcarbonyl]pentylamino]-1(R)-(3,5-dibromo-4-hydroxybenzyl)-2-oxoethyl]-4-(2-oxo-1,2,3,4-tetrahydroquinazolin-3-yl)piperidine-1-carboxamide

Olcegepant

1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine

BIBN 4096BS API Olcegepant

Piperazine, 1-[3,5-dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-

Olcegepant（ BIBN-4096）

inhibit,BIBN4096,Olcegepant,CGRP Receptor,Calcitonin gene-related peptide receptor,BIBN 4096,Inhibitor

Olcegepant/BIBN-4096/BIBN 4096BS

Olcegepant, CGRP antagonist

Olcegepant, 10 mM in DMSO

N-((R)-1-(((S)-6-Amino-1-oxo-1-(4-(pyridin-4-yl)piperazin-1-yl)hexan-2-yl)amino)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide

204697-65-4

C38H47Br2N9O5