ChemicalBook > CAS DataBase List > Ro 5-3335

Ro 5-3335

Product Name
Ro 5-3335
CAS No.
30195-30-3
Chemical Name
Ro 5-3335
Synonyms
Ro 5-3335;NSC-66020;Ro5-3335 ，E1245;CBFβ-Runx1 inhibitor II;7-Chloro-5-(1H-pyrrol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one;7-Chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one;7-Chloro-2-oxo-5-(1H-pyrrol-2-yl)-2,3-dihydro-1H-1,4-benzodiazepine;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-;Ro5-3335,Ro53335,CBFβ,inhibit,binding,Ro-5-3335,core,RUNX1,RUNX1-CBFB,factor,CBF,interaction,leukemia,Inhibitor,Ro5 3335
CBNumber
CB31365501
Molecular Formula
C13H10ClN3O
Formula Weight
259.69
MOL File
30195-30-3.mol
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Ro 5-3335 Property

Melting point:
256 °C(dec.)
solubility 
Soluble to 100 mM in DMSO
form 
powder to crystal
color 
White to Light red to Green
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Safety

HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical
Product number
R0223
Product name
Ro 5-3335
Packaging
10MG
Price
$167
Updated
2025/07/31
TCI Chemical
Product number
R0223
Product name
Ro 5-3335
Packaging
50MG
Price
$586
Updated
2025/07/31
Tocris
Product number
4694
Product name
Ro 5-3335
Purity
≥98%(HPLC)
Packaging
10
Price
$238
Updated
2021/12/16
TRC
Product number
R700978
Product name
Ro 5-3335
Packaging
10mg
Price
$215
Updated
2021/12/16
Usbiological
Product number
256486
Product name
Ro 5-3335
Packaging
10mg
Price
$495
Updated
2021/12/16
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Ro 5-3335 Chemical Properties,Usage,Production

Uses

Ro 5-3335 is a benzodiazepine is a core binding factor (CBF) leukemia inhibitor.

Definition

ChEBI: A 1,4-benzodiazepinone that is nordazepam in which the phenyl substituent has been replaced by a 1H-pyrrol-2-yl group. It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivati n.

in vivo

Ro5-3335 is identified as an inhibitor of RUNX1–CBFβ function in zebrafish models[1].
Ro5-3335 rescues preleukemic phenotype in a RUNX1-ETO transgenic zebrafish[1].
Ro5-3335 (300 mg/kg/d; p.o; for 30 days) reduces leukemia burden in a mouse CBFB-MYH11 leukemia model[1].

Animal Model:C57BL/6 mice (leukemic model)[1]
Dosage:300 mg/kg
Administration:Oral administration; daily; for 30 days
Result:Reduced the number of c-kit+ cells in the transplanted mice and leukemic cell infiltration in the livers, bone marrow and spleen.

storage

Store at +4°C

Ro 5-3335 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 5-3335 Suppliers

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30195-30-3, Ro 5-3335Related Search:


  • Ro 5-3335
  • 7-Chloro-2-oxo-5-(1H-pyrrol-2-yl)-2,3-dihydro-1H-1,4-benzodiazepine
  • NSC-66020
  • 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one
  • CBFβ-Runx1 inhibitor II
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-
  • 7-Chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-5-(1H-pyrrol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
  • Ro5-3335,Ro53335,CBFβ,inhibit,binding,Ro-5-3335,core,RUNX1,RUNX1-CBFB,factor,CBF,interaction,leukemia,Inhibitor,Ro5 3335
  • Ro5-3335 ，E1245
  • 30195-30-3