antarelix

Product Name: antarelix
CAS No.: 151272-78-5
Chemical Name: antarelix
Synonyms: antarelix;D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-(aminocarbonyl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-
CBNumber: CB31383659
Molecular Formula: C74H100ClN15O14
Formula Weight: 1459.13
MOL File: 151272-78-5.mol

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antarelix Property

Water Solubility: >10g/L(temperature not stated)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0003615
Product name: ANTARELIX
Purity: 95.00%
Packaging: 1MG
Price: $836.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0003615
Product name: ANTARELIX
Purity: 95.00%
Packaging: 5MG
Price: $1791.41
Updated: 2021/12/16

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antarelix Chemical Properties,Usage,Production

Uses

Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer[1][2].

in vivo

Teverelix (3-300 μg/kg, intramuscular injection) inhibits testosterone in rats^[3].
Teverelix (1 mg/kg, s.c, daily for 3 days) abolishes luteal function in stumptailed macaques^[4].

Animal Model:	Rats^[3]
Dosage:	300, 100, 30, 10 and 3 μg/kg
Administration:	Intramuscular injection
Result:	Showed dose-response and time-course of testosterone inhibitory activity.

References

[1] MacLean CM, et al. Pharmacokinetic, Safety, and Pharmacodynamic Properties of Teverelix Trifluoroacetate, a Novel Gonadotropin-Releasing Hormone Antagonist, in Healthy Adult Subjects. Clin Pharmacol Drug Dev. 2022 Feb;11(2):257-269. DOI:10.1002/cpdd.1008
[2] Sperduti S, et al. GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors. Int J Mol Sci. 2019 Nov 7;20(22):5548. DOI:10.3390/ijms20225548
[3] Deghenghi R, et al. Antarelix (EP 24332) a novel water soluble LHRH antagonist. Biomed Pharmacother. 1993;47(2-3):107-10. DOI:10.1016/0753-3322(93)90299-z
[4] Fraser HM, et al. Initiation of high dose gonadotrophin-releasing hormone antagonist treatment during the late follicular phase in the macaque abolishes luteal function irrespective of effects upon the luteinizing hormone surge. Hum Reprod. 1997 Mar;12(3):430-5. DOI:10.1093/humrep/12.3.430

antarelix Preparation Products And Raw materials

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antarelix Suppliers

China 7 United States 1 Global 8

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
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Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7618
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Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 7190
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TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29431
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YantaiBio

Tel: 13758194781
Email: 764619768@qq.com
Country: China
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Fuan Bio

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Email: 2845971812@qq.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39040
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Guangzhou Suyan Biotechnology Co., Ltd

Tel: 18818417021
Country: CHINA
ProdList: 6927
Advantage: 58

151272-78-5, antarelixRelated Search:

antarelix N-L-phenylalanyl-L-2-amino-1-phenylpropane

antarelix

D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-(aminocarbonyl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-

151272-78-5

C74H100ClN15O14