SDZ MKS 492
- Product Name
- SDZ MKS 492
- CAS No.
- 114606-56-3
- Chemical Name
- SDZ MKS 492
- Synonyms
- MKS 492;SDZ MKS 492;SDZ MKS 492,SDZMKS 492;1H-Purine-2,6-dione, 8-[[(1R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethyl]amino]-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl-
- CBNumber
- CB31396204
- Molecular Formula
- C20H27N5O6
- Formula Weight
- 433.46
- MOL File
- 114606-56-3.mol
SDZ MKS 492 Property
- Boiling point:
- 648.7±65.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (576.75 mM; Need ultrasonic)
- form
- Solid
- pka
- 14.25±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0018160
- Product name
- SDZ-MKS492
- Purity
- 98.07%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- API0025293
- Product name
- SDZ MKS 492
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.85
- Updated
- 2021/12/16
- Product number
- CS-0018160
- Product name
- SDZ-MKS492
- Purity
- 98.07%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0018160
- Product name
- SDZ-MKS492
- Purity
- 98.07%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0018160
- Product name
- SDZ-MKS492
- Purity
- 98.07%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
SDZ MKS 492 Chemical Properties,Usage,Production
Uses
SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats[1].
in vivo
MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs[1].
MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs[1].
MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs[1].
MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats[1].
| Animal Model: | Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum[1] |
| Dosage: | 3, 10 mg/kg |
| Administration: | I.v. 5 min before antigen challenge |
| Result: | Inhibited antigen-induced bron choconstriction in a dose-related manner. |
References
[1] Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13. DOI:10.1254/jjp.63.405
[2] Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10. PMID:1793072
SDZ MKS 492 Preparation Products And Raw materials
Raw materials
Preparation Products
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