ChemicalBook > CAS DataBase List > ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
Uses- Product Name
- ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
- CAS No.
- 110543-98-1
- Chemical Name
- ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
- Synonyms
- Arbidol Impurity 62;Arbidol Impurity 40;Abidore Impurity 31;Abbidore intermediate 4;5-Acetoxy-6-bromo-2-(bromomethyL;Ethyl 5-acetoxy-6-broMo-2-broMoMethyl-1-Methylindo;ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.;ETHYL 5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METH 110543-98-1;Ethyl 5-Acetoxy-6-Bromo-2-(Bromomethyl)-1-Methylindole-3-Car...;Ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-metyl-indol-3carboxylate
- CBNumber
- CB31430768
- Molecular Formula
- C15H15Br2NO4
- Formula Weight
- 433.09
- MOL File
- 110543-98-1.mol
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ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Property
- Melting point:
- 168-171 °C(Solv: carbon tetrachloride (56-23-5))
- Boiling point:
- 529.8±50.0 °C(Predicted)
- Density
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Brown to gray Solid
- InChI
- InChI=1S/C15H15Br2NO4/c1-4-21-15(20)14-9-5-13(22-8(2)19)10(17)6-11(9)18(3)12(14)7-16/h5-6H,4,7H2,1-3H3
- InChIKey
- MESMQGKAVXOGHJ-UHFFFAOYSA-N
- SMILES
- N1(C)C2=C(C=C(OC(C)=O)C(Br)=C2)C(C(OCC)=O)=C1CBr
- CAS DataBase Reference
- 110543-98-1(CAS DataBase Reference)
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- E898813
- Product name
- Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1h-indole-3-carboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- E898813
- Product name
- Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1h-indole-3-carboxylate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
AK Scientific
- Product number
- X8949
- Product name
- Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate
- Packaging
- 25g
- Price
- $137
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR350162
- Product name
- Ethyl 5-Acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-carboxylate
- Packaging
- 5g
- Price
- $176
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H58-9-1E
- Product name
- Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-carboxylate
- Packaging
- 5G
- Price
- $208
- Updated
- 2021/12/16
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ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Chemical Properties,Usage,Production
Uses
Ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate can be used as an intermediate for Arbidol.
Synthesis
40945-79-7
110543-98-1
General procedure for the synthesis of ethyl 1-methyl-2-(bromomethyl)-5-acetoxy-6-bromoindole-3-carboxylate from ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate: 137.6 g (0.45 mol) of ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate was dissolved in 1000 mL of chloroform with stirring until completely dissolved. A catalytic amount of benzoyl peroxide was added and heated to reflux. 64.0 mL (200 g, 1.25 mol) of liquid bromine was added slowly dropwise and the reaction was continued at reflux for 3 hours after completion of the dropwise addition. Upon completion of the reaction, the reaction mixture was cooled to room temperature and a solid was precipitated. The solid was washed with a small amount of methanol and dried to give 184.0 g of ethyl 1-methyl-2-(bromomethyl)-5-acetoxy-6-bromoindole-3-carboxylate in 85.0% yield.
References
[1] Pharmaceutical Chemistry Journal, 1993, vol. 27, # 1, p. 75 - 76
[2] Khimiko-Farmatsevticheskii Zhurnal, 1993, vol. 27, # 1, p. 70 - 71
[3] Patent: CN106083691, 2016, A. Location in patent: Paragraph 0025; 0055; 0056
[4] Patent: US5198552, 1993, A
[5] Patent: EP1731506, 2006, A1. Location in patent: Page/Page column 12; 16
ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. manufacturers
Nanjing Fred Technology Co., Ltd
- Product
- Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate 110543-98-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%HPLC
- Supply Ability
- 20 tons
- Release date
- 2023-12-04
Career Henan Chemical Co
- Product
- ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. 110543-98-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 477
- Release date
- 2019-09-01
Career Henan Chemical Co
- Product
- ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. 110543-98-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 478
- Release date
- 2019-09-01