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Methyl 4-(4-hydroxymethylphenyl)benzoate

Product Name
Methyl 4-(4-hydroxymethylphenyl)benzoate
CAS No.
393522-78-6
Chemical Name
Methyl 4-(4-hydroxymethylphenyl)benzoate
Synonyms
Methyl 4-(4-hydroxymethylphenyl)benzoate;Methyl 4'-(hydroxymethyl)-[1,1'-biphenyl]-4-carboxylate;[1,1'-Biphenyl]-4-carboxylic acid, 4'-(hydroxymethyl)-, methyl ester
CBNumber
CB31455729
Molecular Formula
C15H14O3
Formula Weight
242.27
MOL File
393522-78-6.mol
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Methyl 4-(4-hydroxymethylphenyl)benzoate Property

storage temp. 
Sealed in dry,Room Temperature
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed
Product number
A143512
Product name
Methyl4'-(hydroxymethyl)-[1,1'-biphenyl]-4-carboxylate
Purity
97%
Packaging
100mg
Price
$65
Updated
2021/12/16
Ambeed
Product number
A143512
Product name
Methyl4'-(hydroxymethyl)-[1,1'-biphenyl]-4-carboxylate
Purity
97%
Packaging
250mg
Price
$65
Updated
2021/12/16
Ambeed
Product number
A143512
Product name
Methyl4'-(hydroxymethyl)-[1,1'-biphenyl]-4-carboxylate
Purity
97%
Packaging
1g
Price
$194
Updated
2021/12/16
Crysdot
Product number
CD12075789
Product name
Methyl4'-(hydroxymethyl)-[1,1'-biphenyl]-4-carboxylate
Purity
97%
Packaging
1g
Price
$311
Updated
2021/12/16
Crysdot
Product number
CD12075789
Product name
Methyl4'-(hydroxymethyl)-[1,1'-biphenyl]-4-carboxylate
Purity
97%
Packaging
5g
Price
$1019
Updated
2021/12/16
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Methyl 4-(4-hydroxymethylphenyl)benzoate Chemical Properties,Usage,Production

Synthesis

873-75-6

99768-12-4

393522-78-6

To 4-bromobenzyl alcohol (500 mg, 2.94 mmol) and 4-methoxycarbonylphenylboronic acid (550 mg, 3.53 mmol) were added Pd(OAc)2 (200 mg, 735 μmol) and Na2CO3 (3 g, dissolved in 20 mL of H2O) as a raw material after dissolution in DMF (20 mL). The reaction mixture was stirred at 70 °C for 48 hours. After completion of the reaction, extraction was carried out with EtOAc, the organic layers were combined and washed with brine, dried over MgSO4, filtered and concentrated in vacuum. Purification by column chromatography (eluent: EtOAc/n-heptane, 1:4) afforded the target product methyl 4'-(hydroxymethyl)-[1,1'-biphenyl]-4-carboxylate (170 mg, 24% yield) as white crystals. rf = 0.3 (EtOAc/n-heptane, 1:1). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.15-8.06 (m, 2H), 7.70-7.58 (m, 4H), 7.52-7.43 (m, 2H), 4.77 (d, J = 3.1 Hz, 2H), 4.07-3.67 (m, 3H), 1.75 (br s, 1H, OH) ppm. FTIR spectra showed characteristic absorption peaks: 3305, 3032, 1718, 1604, 1432, 1399, 1286, 1271, 1220, 1117, 765 cm-1. HRMS (EI) analysis results: calculated value C15H14O3 (M)+ 242.0942, measured value 242.0919.

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 20, p. 5593 - 5603

Methyl 4-(4-hydroxymethylphenyl)benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-(4-hydroxymethylphenyl)benzoate Suppliers

China 12 India 1 United States 3 Global 16
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393522-78-6, Methyl 4-(4-hydroxymethylphenyl)benzoateRelated Search:


  • Methyl 4-(4-hydroxymethylphenyl)benzoate
  • [1,1'-Biphenyl]-4-carboxylic acid, 4'-(hydroxymethyl)-, methyl ester
  • Methyl 4'-(hydroxymethyl)-[1,1'-biphenyl]-4-carboxylate
  • 393522-78-6