2-nitro-3-(trifluoromethyl)aniline
- Product Name
- 2-nitro-3-(trifluoromethyl)aniline
- CAS No.
- 386-71-0
- Chemical Name
- 2-nitro-3-(trifluoromethyl)aniline
- Synonyms
- NSC 10269;2-nitro-3-amino trifluorotolue;3-Amino-2-nitrobenzotrifluoride;3-Trifluoromethyl-2-nitroaniline;2-nitro-3-aMino trifluorotoluene;2-nitro-3-(trifluoromethyl)aniline;2-Nitro-3-(trifluoromethyl)benzenamine;(2-Nitro-3-trifluoroMethylphenyl)aMine;Benzenamine, 2-nitro-3-(trifluoromethyl)-
- CBNumber
- CB31459691
- Molecular Formula
- C7H5F3N2O2
- Formula Weight
- 206.12
- MOL File
- 386-71-0.mol
2-nitro-3-(trifluoromethyl)aniline Property
- Melting point:
- 64 °C
- Boiling point:
- 287.2±40.0 °C(Predicted)
- Density
- 1.503±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- crystalline powder
- pka
- -1.45±0.10(Predicted)
- color
- Golden yellow to faint orange (hint of green)
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC53489
- Product name
- 2-Nitro-3-(trifluoromethyl)aniline
- Packaging
- 250mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 4855-3-08
- Product name
- 2-Nitro-3-(trifluoromethyl)aniline
- Packaging
- 250mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- 5003AB
- Product name
- 2-Nitro-3-(trifluoromethyl)benzenamine
- Packaging
- 250mg
- Price
- $177
- Updated
- 2021/12/16
- Product number
- PC53489
- Product name
- 2-Nitro-3-(trifluoromethyl)aniline
- Packaging
- 1g
- Price
- $247
- Updated
- 2021/12/16
- Product number
- 4855-3-08
- Product name
- 2-Nitro-3-(trifluoromethyl)aniline
- Packaging
- 1g
- Price
- $272
- Updated
- 2021/12/16
2-nitro-3-(trifluoromethyl)aniline Chemical Properties,Usage,Production
Synthesis
387-19-9
386-71-0
Step 3: Synthesis of 2-nitro-3-(trifluoromethyl)aniline; N-(2-nitro-3-(trifluoromethyl)phenyl)acetamide (0.9 g, 3.6 mmol) was dissolved in ethanol (23 mL), followed by addition of 20% aqueous sodium hydroxide solution (4.5 mL). The reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by evaporation. The residue was diluted with water (50 mL) and extracted with ethyl acetate (2 x 25 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated to dryness to give 2-nitro-3-(trifluoromethyl)aniline as a yellow solid (0.67 g, 95.54% yield).1H NMR (300 MHz, DMSO-d6): δ (ppm) = 7.4-7.3 (m, 1H), 7.3 (d, J = 12Hz, 1H), 7.4-6.8 (m, 1H), 5.00 (pp. 1H), 5.00 (bs, 2H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 2, p. 526 - 530
[2] Patent: WO2010/115736, 2010, A2. Location in patent: Page/Page column 101
[3] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 190
[4] Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1927, vol. <5> 13, p. 349
[5] Chem. Zentralbl., 1927, vol. 98, # II, p. 1817
2-nitro-3-(trifluoromethyl)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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