ChemicalBook > CAS DataBase List > AMG-1

AMG-1

Product Name
AMG-1
CAS No.
913376-84-8
Chemical Name
AMG-1
Synonyms
AMG-1;SYN1143;RON-IN-1;AMG1;AMG 1;RON-IN-1 (AMG-1);SYN1143, 10 mM in DMSO;c-Met/RON Dual Kinase Inhibitor;RON Dual Kinase Inhibitor inhibitor;c-Met/RON Dual Kinase Inhibitor inhibitor;c-Met/HGFR,SYN-1143,tumor,RON,dual,inhibit,SYN1143,SYN 1143,cancer,Inhibitor,c-Met
CBNumber
CB31469179
Molecular Formula
C31H29FN4O5
Formula Weight
556.58
MOL File
913376-84-8.mol
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AMG-1 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (179.67 mM; Need ultrasonic)
form 
Solid
color 
Light yellow to yellow
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Safety

WGK Germany 
WGK 2
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
448104
Product name
c-Met/RON Dual Kinase Inhibitor - CAS 913376-84-8 - Calbiochem
Purity
The c-Met/RON Dual Kinase Inhibitor, also referenced under CAS 913376-84-8, controls the biological activity of c-Met/RON.
Packaging
5MG
Price
$294
Updated
2023/01/07
Cayman Chemical
Product number
41226
Product name
AMG 1
Purity
≥98%
Packaging
5mg
Price
$121
Updated
2026/04/30
Cayman Chemical
Product number
41226
Product name
AMG 1
Purity
≥98%
Packaging
10mg
Price
$218
Updated
2026/04/30
Cayman Chemical
Product number
41226
Product name
AMG 1
Purity
≥98%
Packaging
25mg
Price
$455
Updated
2026/04/30
Cayman Chemical
Product number
41226
Product name
AMG 1
Purity
≥98%
Packaging
50mg
Price
$666
Updated
2026/04/30
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AMG-1 Chemical Properties,Usage,Production

Uses

AMG-1 is a potent inhibitor of human c-Met and RON.

Definition

ChEBI: N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-4-pyrazolecarboxamide is an aromatic amide.

in vivo

SYN1143 (10-100 mg/kg; p.o. for 22 d) inhibits the growth of c-Met-dependent and constitutively active RON-expressing tumors in mice[1].
SYN1143 (20-50 μg; transferred into calvarial defects) stimulates bone formation in critical-sized defects of mouse calvarial bone[2].

Animal Model:Female CD1 nu/nu mice (6-8 weeks) bearing NIH3T3 TPR-Met s.c. tumors[1]
Dosage:10, 30, 100 mg/kg
Administration:Oral gavage either once or twice daily for 22 days
Result:Significantly inhibited tumor growth at doses of 30 or 100 mg/kg once daily or at 30 mg/kg twice daily.
Completely inhibited tumor growth at a dose of 100 mg/kg once daily.
Did not adversely affect body weight.

IC 50

RON: 9 nM (IC50)

AMG-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG-1 Suppliers

China 48 France 1 United Kingdom 1 United States 8 Global 58
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13770331960
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16059
Advantage
64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
SYN|thesis med chem P/L
Tel
+86-021-50720296
Fax
+86-021-50720297
Email
service@synkinase.com
Country
China
ProdList
266
Advantage
58
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003;025-846993838003-8003 18013301593;18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
3293
Advantage
55
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
Advantage
60
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
89689
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9550
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58

913376-84-8, AMG-1Related Search:

Sulfanilamide N-ACETYLLACTOSAMINE 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Deionized water

  • AMG-1
  • N-[3-Fluoro-4-[(7-Methoxyquinolin-4-yl)oxy]phenyl]-1-(2-hydroxy-2-Methylpropyl)-5-Methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxaMide
  • AMG1;AMG 1
  • 1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-
  • RON-IN-1 (AMG-1)
  • RON-IN-1
  • SYN1143
  • c-Met/HGFR,SYN-1143,tumor,RON,dual,inhibit,SYN1143,SYN 1143,cancer,Inhibitor,c-Met
  • SYN1143, 10 mM in DMSO
  • c-Met/RON Dual Kinase Inhibitor
  • c-Met/RON Dual Kinase Inhibitor inhibitor
  • RON Dual Kinase Inhibitor inhibitor
  • 913376-84-8
  • C31H29FN4O5
  • C16H18N6O5