4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE)
- Product Name
- 4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE)
- CAS No.
- 3274-12-2
- Chemical Name
- 4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE)
- Synonyms
- NSC 407523;4-Methyl-4-(trichloromethyl)cyclohexa-2,5-dienone;4-Methyl-4-(trichloroMeth yl)-2,5-cyclohexadienone;4-Trichloromethyl-4-methyl-2,5-cyclohexadien-1-one;4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE);4-Methyl-4-(trichloroMethyl)cyclohexa-2,5-dien-1-one;4-Methyl-4-(trichloromethyl)-2,5-cyclohexadiene-1-one;2,5-Cyclohexadien-1-one,4-Methyl-4-(trichloroMethyl)-;4-Methyl-4-(trichloromethyl)-2,5-cyclohexadienone (4-MTD)
- CBNumber
- CB31474182
- Molecular Formula
- C8H7Cl3O
- Formula Weight
- 225.5
- MOL File
- 3274-12-2.mol
4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE) Property
- Melting point:
- 103-104℃ (ligroine )
- Boiling point:
- 289.0±40.0 °C(Predicted)
- Density
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S264245
- Product name
- 4-METHYL-4-TRICHLOROMETHYL-CYCLOHEXA-2,5-DIENONE
- Purity
- AldrichCPR
- Packaging
- 10MG
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- T774558
- Product name
- 4-Trichloromethyl-4-methyl-2,5-cyclohexadienone
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T774558
- Product name
- 4-Trichloromethyl-4-methyl-2,5-cyclohexadienone
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 2417-5-01
- Product name
- 4-Methyl-4-(trichloromethyl)-2,5-cyclohexadien-1-one
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 2417-5-01
- Product name
- 4-Methyl-4-(trichloromethyl)-2,5-cyclohexadien-1-one
- Packaging
- 500mg
- Price
- $495
- Updated
- 2021/12/16
4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE) Chemical Properties,Usage,Production
Synthesis
56-23-5
106-44-5
3274-12-2
In this embodiment, 4-methyl-4-(trichloromethyl)cyclohexa-2,5-dienone is prepared, comprising the following steps: S1: 160 g of aluminum trichloride was weighed and added to 670 g of dichloroethane, placed in a reaction flask with stirring, and cooled to 5 °C. Weigh 100g of p-toluol dissolved in 330g of dichloroethane, placed in a constant pressure dropping funnel, and slowly added dropwise to the dichloroethane reaction system of aluminum trichloride. The reaction temperature was maintained at 11°C during the dropwise addition. After the dropwise addition was completed, 140 g of carbon tetrachloride was added, the temperature was raised to 38°C, and the reaction was continued with stirring for 2 hours. Upon completion of the reaction, the heating was stopped. In this step, p-toluene and carbon tetrachloride were used as the reaction feedstock, aluminum trichloride was used as the catalyst, and dichloroethane was used as the solvent. S2: The reaction mixture was cooled to room temperature and then slowly added to 1000 g of ice water and stirred for 30 min. S3: Liquid-liquid separation was carried out at 5°C, and vacuum distillation was used to remove the organic solvent to obtain 195 g of residue. S4: 488 g of methanol and 10 g of activated carbon were added to the residue, heated to reflux (78°C) and stirred for 30 minutes. After hot filtration, the precipitated solid was cooled, filtered and dried to give 184g of wet crystalline product, which showed higher purity by HPLC. S5: 184 g of crude product was mixed with 460 g of methanol, 9.2 g of activated charcoal was added and heated to reflux at 65 °C for 30 min. After hot filtration, the precipitated solid was cooled, filtered and dried to give 71 g of white crystalline pure product with HPLC purity greater than 98% and 34% yield.
References
[1] Patent: CN104725207, 2016, B. Location in patent: Paragraph 0068; 0069; 0070; 0071; 0072; 0073; 0074-0076
[2] Berichte der Bunsen-Gesellschaft, 1990, vol. 94, p. 497 - 513
[3] Chemische Berichte, 1906, vol. 39, p. 4125
[4] Journal of Organic Chemistry, 1954, vol. 19, p. 996,1000
[5] Tetrahedron, 1974, vol. 30, p. 3573 - 3581
4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE) manufacturers
- Product
- 4-METHYL-4-TRICHLOROMETHYL-2,5-CYCLOHEXADIEN-1-ONE) 3274-12-2
- Price
- US $0.00/KG
- Min. Order
- 0.100000001490116KG
- Purity
- 98%
- Supply Ability
- 1000KGS
- Release date
- 2025-11-24