1'-HYDROXYMIDAZOLAM

Product Name: 1'-HYDROXYMIDAZOLAM
CAS No.: 59468-90-5
Chemical Name: 1'-HYDROXYMIDAZOLAM
Synonyms: α-Hydroxymidazolam;ALPHA-HYDROXYMIDAZOLAM;1-Oh-mdz;RO 21-6347;A-HYDROXYMIDAZOLAM;1Hydroxymidazolame;1-HYDROXY MIDAZOLAM;1'-Hydroxymidazolam;Midazolam Impurity 1;Midazolam Impurity 12
CBNumber: CB3147586
Molecular Formula: C18H13ClFN3O
Formula Weight: 341.77
MOL File: 59468-90-5.mol

More

Less

1'-HYDROXYMIDAZOLAM Property

Melting point:: 264-266oC
Boiling point:: 540.6±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
Flash point:: 9℃
storage temp.: 2-8°C
solubility: DMF: 2 mg/ml; DMSO: 1 mg/ml
form: A crystalline solid
pka: 13.59±0.10(Predicted)
color: white or off-white

More

Less

Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H-922
Product name: α-Hydroxymidazolam solution
Purity: 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $342
Updated: 2025/07/31

Sigma-Aldrich

Product number: H-902
Product name: α-Hydroxymidazolam solution
Purity: 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $37.2
Updated: 2025/07/31

Cayman Chemical

Product number: 10385
Product name: 1'-Hydroxymidazolam
Purity: ≥95%
Packaging: 1mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 10385
Product name: 1'-Hydroxymidazolam
Purity: ≥95%
Packaging: 5mg
Price: $195
Updated: 2024/03/01

Sigma-Aldrich

Product number: UC430
Product name: 1′-Hydroxymidazolam
Packaging: 5mg
Price: $1510
Updated: 2025/07/31

More

Less

1'-HYDROXYMIDAZOLAM Chemical Properties,Usage,Production

Description

1''-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.

Chemical Properties

White Solid

Uses

CYP3A4 metabolite of midazolam

Uses

A metabolite of Midazolam (M343000).

Definition

ChEBI: 1-hydroxymidazolam is an imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. It has a role as a drug metabolite, a human blood serum metabolite and a human urinary metabolite. It is an imidazobenzodiazepine, an organochlorine compound, a member of monofluorobenzenes and an aromatic primary alcohol. It is functionally related to a midazolam.

References

[1] M D PERLOFF. Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 292 2: 618-628.
[2] T M BAUER. Prolonged sedation due to accumulation of conjugated metabolites of midazolam.[J]. Lancet (London, England), 1995, 346 8968: 145-147. DOI: 10.1016/s0140-6736(95)91209-6
[3] RYOSUKE NEGORO. Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System[J]. Cells, 2022. DOI: 10.3390/cells11101677

1'-HYDROXYMIDAZOLAM Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1'-HYDROXYMIDAZOLAM Suppliers

Canada 2 China 32 France 1 Germany 1 India 3 Switzerland 1 United Kingdom 1 United States 12 Global 53

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14246
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

iPHASE Biosciences

Tel: 010-59755330 13701268334
Fax: 010-59755320
Email: support@iphasebio.com
Country: China
ProdList: 510
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10945
Advantage: 58

Manhag Testing Technology Co., Ltd

Tel: 020-3846 2365 19110442770
Email: 458677837@qq.com
Country: China
ProdList: 7775
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

amyjetsci

Tel: 027-59626688 18771149750
Email: sales@amyjet.com
Country: China
ProdList: 2917
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18921922613
Email: hywu@aikonchem.com
Country: China
ProdList: 10709
Advantage: 58

Scinova Biotech(Guangzhou) Co., Ltd.

Tel: 13268215580
Email: scinova_sales@163.com
Country: China
ProdList: 7025
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Guangdong Fangxin Biotechnology Co., Ltd.

Tel: 0751-2838688 13376594225
Email: 1276075424@qq.com
Country: China
ProdList: 9942
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9650
Advantage: 58

Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd

Tel: 020-18102736 18102736234
Email: LK@zlstandards.com
Country: China
ProdList: 8206
Advantage: 58

Guangzhou Tosun Pharmaceutical Limited

Tel: +86-18124244216 +86-18124244216
Email: info@upharm.cn
Country: China
ProdList: 998
Advantage: 58

China National Standard Pharmaceutical Corporation Limited

Tel: +8615391658522
Email: overseasales@yongstandards.com
Country: China
ProdList: 11922
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6170
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6518
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Chempro Tech Co., Ltd.

Tel: --
Fax: --
Country: China
ProdList: 6800
Advantage: 60

DeBioChem

Tel: --
Fax: --
Email: descibio@sohu.com
Country: China
ProdList: 3333
Advantage: 34

59468-90-5, 1'-HYDROXYMIDAZOLAMRelated Search:

Bupropion Midazolam Midazolam 4-HYDROXYMIDAZOLAM 4-Hydroxymidazolam b-D-Glucuronide,4-Hydroxymidazolam -D-Glucuronide ALPHA-HYDROXYMIDAZOLAM UNLABELED 100 UG/ML IN METHANOL 4-HYDROXYMIDAZOLAM 1-HYDROXY MIDAZOLAM-13C2 a-Hydroxymidazolam-13C3, 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine-13C3,,1'-HYDROXYMIDAZOLAM-13C3 1'-HYDROXYMIDAZOLAM ALPHA-HYDROXYMIDAZOLAM-D4 1'-HYDROXYMIDAZOLAM-?-D-GLUCURONIDE,1Hydroxymidazolam-b-D-glucuronide 1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE 1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE 5-OXIDE

ALPHA-HYDROXYMIDAZOLAM

8-CHLORO-6-(2-FLUOROPHENYL)-1-HYDROXYMETHYL-4H-IMIDAZO[1,5A][1,4]BENZODIAZEPINE

A-HYDROXYMIDAZOLAM

RO 21-6347

1-HYDROXY MIDAZOLAM

1Hydroxymidazolame

alpha-Hydroxymidazolame

4H-Imidazo1,5-a1,4benzodiazepine-1-methanol, 8-chloro-6-(2-fluorophenyl)-

1-hydroxymethylmidazolam

8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol

α-Hydroxymidazolam

1-Oh-mdz

1'-Hydroxy MidazolaM (100 μg/ML in Methanol)

α-Hydroxymidazolam solution

CYP3A4 metabolite of Midazolam

1’-Hydroxy Midazolam (1.0 mg/mL in methanol)

1'-hydroxy Midazolam (Ro 21-6347)

1'-Hydroxymidazolam

α-hydroxy Midazolam (CRM)

Midazolam Impurity 12

Midazolam Impurity 1

alpha-Hydroxymidazolam 0.1 mg/ml in Methanol

1’-Hydroxy Midazolam (100 ug/mL in methanol)

Alpha-Hydroxymidazolam, 1mg/ml in Methanol

59468-90-5

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Metabolites