1'-HYDROXYMIDAZOLAM

Product Name: 1'-HYDROXYMIDAZOLAM
CAS No.: 59468-90-5
Chemical Name: 1'-HYDROXYMIDAZOLAM
Synonyms: α-Hydroxymidazolam;ALPHA-HYDROXYMIDAZOLAM;1-Oh-mdz;RO 21-6347;A-HYDROXYMIDAZOLAM;1Hydroxymidazolame;1-HYDROXY MIDAZOLAM;1'-Hydroxymidazolam;Midazolam Impurity 1;Midazolam Impurity 12
CBNumber: CB3147586
Molecular Formula: C18H13ClFN3O
Formula Weight: 341.77
MOL File: 59468-90-5.mol

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1'-HYDROXYMIDAZOLAM Property

Melting point:: 264-266oC
Boiling point:: 540.6±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
Flash point:: 9℃
storage temp.: 2-8°C
solubility: DMF: 2 mg/ml; DMSO: 1 mg/ml
form: A crystalline solid
pka: 13.59±0.10(Predicted)
color: white or off-white

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H-922
Product name: α-Hydroxymidazolam solution
Purity: 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $336
Updated: 2024/03/01

Sigma-Aldrich

Product number: H-902
Product name: α-Hydroxymidazolam solution
Purity: 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $36.6
Updated: 2024/03/01

Cayman Chemical

Product number: 10385
Product name: 1'-Hydroxymidazolam
Purity: ≥95%
Packaging: 1mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 10385
Product name: 1'-Hydroxymidazolam
Purity: ≥95%
Packaging: 5mg
Price: $195
Updated: 2024/03/01

Sigma-Aldrich

Product number: UC430
Product name: 1′-Hydroxymidazolam
Packaging: 5mg
Price: $1470
Updated: 2024/03/01

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1'-HYDROXYMIDAZOLAM Chemical Properties,Usage,Production

Description

1''-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.

Chemical Properties

White Solid

Uses

CYP3A4 metabolite of midazolam

Uses

A metabolite of Midazolam (M343000).

Definition

ChEBI: 1-hydroxymidazolam is an imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. It has a role as a drug metabolite, a human blood serum metabolite and a human urinary metabolite. It is an imidazobenzodiazepine, an organochlorine compound, a member of monofluorobenzenes and an aromatic primary alcohol. It is functionally related to a midazolam.

1'-HYDROXYMIDAZOLAM Preparation Products And Raw materials

Raw materials

Preparation Products

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1'-HYDROXYMIDAZOLAM Suppliers

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59468-90-5, 1'-HYDROXYMIDAZOLAMRelated Search:

Bupropion Midazolam Midazolam 4-HYDROXYMIDAZOLAM 4-Hydroxymidazolam b-D-Glucuronide,4-Hydroxymidazolam -D-Glucuronide ALPHA-HYDROXYMIDAZOLAM UNLABELED 100 UG/ML IN METHANOL 4-HYDROXYMIDAZOLAM 1-HYDROXY MIDAZOLAM-13C2 a-Hydroxymidazolam-13C3, 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine-13C3,,1'-HYDROXYMIDAZOLAM-13C3 1'-HYDROXYMIDAZOLAM ALPHA-HYDROXYMIDAZOLAM-D4 1'-HYDROXYMIDAZOLAM-?-D-GLUCURONIDE,1Hydroxymidazolam-b-D-glucuronide 1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE 1-ACETOXYMETHYL-8-CHLORO-6-(2-FLUOROPHENYL)-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE 5-OXIDE

ALPHA-HYDROXYMIDAZOLAM

8-CHLORO-6-(2-FLUOROPHENYL)-1-HYDROXYMETHYL-4H-IMIDAZO[1,5A][1,4]BENZODIAZEPINE

A-HYDROXYMIDAZOLAM

RO 21-6347

1-HYDROXY MIDAZOLAM

1Hydroxymidazolame

alpha-Hydroxymidazolame

4H-Imidazo1,5-a1,4benzodiazepine-1-methanol, 8-chloro-6-(2-fluorophenyl)-

1-hydroxymethylmidazolam

8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol

α-Hydroxymidazolam

1-Oh-mdz

1'-Hydroxy MidazolaM (100 μg/ML in Methanol)

α-Hydroxymidazolam solution

Midazolam Impurity 1

CYP3A4 metabolite of Midazolam

Midazolam Impurity 12

1’-Hydroxy Midazolam (1.0 mg/mL in methanol)

1'-hydroxy Midazolam (Ro 21-6347)

1'-Hydroxymidazolam

59468-90-5

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Metabolites