ChemicalBook > CAS DataBase List > 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE

4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE

Product Name: 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE
CAS No.: 287952-67-4
Chemical Name: 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE
Synonyms: Delamanid intermediate;Piperidine, 4-[4-(trifluoroMethoxy)phenoxy]-;4-[4-(TrifluoroMethoxy)phenoxy]piperidine HCl
CBNumber: CB31476863
Molecular Formula: C12H14F3NO2
Formula Weight: 261.24
MOL File: 287952-67-4.mol

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4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE Property

Melting point:: 71-73℃
Boiling point:: 292.2±40.0 °C(Predicted)
Density: 1.230±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: powder to crystal
pka: 9.65±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C12H14F3NO2/c13-12(14,15)18-11-3-1-9(2-4-11)17-10-5-7-16-8-6-10/h1-4,10,16H,5-8H2
InChIKey: RPQOTFPZKNHYFB-UHFFFAOYSA-N
SMILES: N1CCC(OC2=CC=C(OC(F)(F)F)C=C2)CC1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933.39.9200
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000104
Product name: 4-[4-(Trifluoromethoxy)phenoxy]piperidine
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TCI Chemical

Product number: T3349
Product name: 4-[4-(Trifluoromethoxy)phenoxy]piperidine
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $48
Updated: 2025/07/31

TCI Chemical

Product number: T3349
Product name: 4-[4-(Trifluoromethoxy)phenoxy]piperidine
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $235
Updated: 2025/07/31

TRC

Product number: T790890
Product name: 4-[4-(Trifluoromethoxy)phenoxy]piperidine
Packaging: 5g
Price: $415
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 49059
Product name: 4-[4-(Trifluoromethoxy)phenoxy]piperidine
Packaging: 1g
Price: $625
Updated: 2021/12/16

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4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE Chemical Properties,Usage,Production

Uses

4-[4-(Trifluoromethoxy)phenoxy]piperidine is used in the preparation of 3,5-disubstituted isoxazolines as antituberculosis agents.

Synthesis

828-27-3

65214-82-6

287952-67-4

GENERAL STEPS: 9.72 kg of ethyl 4-hydroxypiperidine-1-carboxylate and 10.0 L of triethylamine were dissolved in 15.0 L of toluene and the resulting solution was cooled to below 10 °C. To this solution, 7.07 kg of methanesulfonyl chloride was slowly added dropwise at a temperature below 25 °C, followed by continued stirring for 1 hour at below 25 °C. Next, 5.00 kg of 4-trifluoromethoxyphenol, 10 L of toluene, 17.7 L of 25% aqueous sodium hydroxide and 6.24 kg of 50% aqueous tetra-n-butyl ammonium chloride were added to the reaction solution. The mixture was heated to reflux for 2 hours (internal temperature was maintained at 88°C). After completion of the reaction, the mixture was cooled and the aqueous layer was separated and discarded. The organic layer was washed with 10 L of water. Subsequently, 14.2 kg of potassium hydroxide and 10 L of ethanol were added to the washed organic layer and the mixture was heated to reflux for 4 hours (internal temperature maintained at 98 °C). After cooling, concentration was carried out under reduced pressure. To the concentrated residue, 50 L of toluene was added and the organic layer was washed sequentially with 25 L of water, 25 L of brine and 31 L of aqueous ammonium chloride. The washed toluene solution was concentrated under reduced pressure. The concentrated residue was dissolved in a solvent mixture of 5 L of isopropanol, 50 L of water and 2.5 L of 25% aqueous sodium hydroxide to form a homogeneous solution, which was subsequently cooled to below 10 °C. After the crystals precipitated, stirring was continued below 10 °C for 1 h. The precipitate was then collected by filtration. The crystals were washed with 15 L of water and dried in air to give 6.67 kg of 4-(4-trifluoromethoxyphenoxy)piperidine (isolated yield: 90.9%). 1H-NMR (300 MHz, CDCl3) δ ppm: 1.41 (2H, dddd), 1.90 (2H, m), 2.55 (2H, dddd), 2.92 (2H, dddd), 3.33 (1H, brs), 4.39 (1H, tt), 7.03 (2H, d), 7.25 (2H, d).

References

[1] Patent: US2018/65931, 2018, A1. Location in patent: Paragraph 0135

4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-[4-(trifluoromethoxy)phenoxy]piperidine 287952-67-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Shanghai CRM New Material Technology Co., LTD

Product: 4-(4-Trifluoromethoxyphenoxy)piperidine 287952-67-4
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10t
Release date: 2022-09-21

Career Henan Chemical Co

Product: 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE 287952-67-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-26

287952-67-4, 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINERelated Search:

4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE 3-(4-(TRIFLUOROMETHOXY)PHENOXY)PROPAN-1-AMINE 4-(4-METHOXYPHENOXY)PIPERIDINE 4-(4-Trifluoromethoxy-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Piperidine, 4-[4-(trifluoroMethoxy)phenoxy]-

4-[4-(TrifluoroMethoxy)phenoxy]piperidine HCl

Delamanid intermediate

287952-67-4