ChemicalBook > CAS DataBase List > 2-CHLORO-5-FLUORO-4-IODOPYRIDINE

2-CHLORO-5-FLUORO-4-IODOPYRIDINE

Product Name: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE
CAS No.: 884494-49-9
Chemical Name: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE
Synonyms: Methyl 7-bromopicolinate;2-CHLORO-5-FLUORO-4-IODOPYRIDINE;Pyridine, 2-chloro-5-fluoro-4-iodo-;2-Chloro-5-Fluoro-4-Iodopyridine98%;2-Chloro-5-fluoro-4-iodopyridine 98%;2-CHLORO-5-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH
CBNumber: CB31479147
Molecular Formula: C5H2ClFIN
Formula Weight: 257.43
MOL File: 884494-49-9.mol

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2-CHLORO-5-FLUORO-4-IODOPYRIDINE Property

Boiling point:: 242℃
Density: 2.129
Flash point:: 100℃
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: -2.37±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C5H2ClFIN/c6-5-1-4(8)3(7)2-9-5/h1-2H
InChIKey: CRLPRXQOSARJCF-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(F)C(I)=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C368308
Product name: 2-Chloro-5-fluoro-4-iodopyridine
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Ark Pharm

Product number: P000684456
Product name: 2-Chloro-5-fluoro-4-iodopyridine
Purity: 98%
Packaging: 100mg
Price: $8
Updated: 2021/12/16

Ark Pharm

Product number: P000684456
Product name: 2-Chloro-5-fluoro-4-iodopyridine
Purity: 98%
Packaging: 250mg
Price: $15
Updated: 2021/12/16

ChemScene

Product number: CS-W000348
Product name: 2-Chloro-5-fluoro-4-iodopyridine
Purity: 99.88%
Packaging: 1g
Price: $18
Updated: 2021/12/16

Ark Pharm

Product number: P000684456
Product name: 2-Chloro-5-fluoro-4-iodopyridine
Purity: 98%
Packaging: 1g
Price: $20
Updated: 2021/12/16

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2-CHLORO-5-FLUORO-4-IODOPYRIDINE Chemical Properties,Usage,Production

Synthesis

31301-51-6

884494-49-9

The general procedure for the synthesis of 2-chloro-5-fluoro-4-iodopyridine using 2-chloro-5-fluoropyridine as starting material was as follows: 2-chloro-5-fluoropyridine (10.0 g, 76.0 mmol, 1.0 eq.) was dissolved in anhydrous tetrahydrofuran (THF, 100 mL) under nitrogen protection and cooled to -78 °C. Lithium diisopropylammonium (LDA, 58 mL, 116 mmol, 2 M in THF) was added slowly and the reaction mixture was kept stirred at -78 °C for 3 hours. Subsequently, a solution of iodine (I2, 23.2 g, 91.0 mmol) in THF (100 mL) was slowly added at the same temperature. The reaction mixture continued to be stirred at -78 °C for 1 h. The reaction was then quenched with water (200 mL). The reaction mixture was slowly warmed to room temperature and extracted with ethyl acetate (EtOAc, 100 mL x 2). The organic layers were combined, washed with brine (50 mL × 2), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being petroleum ether (PE) to ethyl acetate/petroleum ether (1/20, v/v) to afford 2-chloro-5-fluoro-4-iodopyridine (11.8 g, 60% yield) as a white solid.1H NMR (400 MHz, CDCl3): δ 8.13 (s, 1H), 7.76 (d, 1H).

References

[1] Patent: WO2017/1936, 2017, A2. Location in patent: Paragraph 00200
[2] Patent: US2017/29404, 2017, A1. Location in patent: Paragraph 0251-0253
[3] Patent: US2014/309225, 2014, A1. Location in patent: Paragraph 0830
[4] Patent: WO2018/49089, 2018, A1. Location in patent: Page/Page column 168
[5] Patent: EP2589592, 2018, B1. Location in patent: Paragraph 0995; 0996

2-CHLORO-5-FLUORO-4-IODOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-FLUORO-4-IODOPYRIDINE Suppliers

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View Lastest Price from 2-CHLORO-5-FLUORO-4-IODOPYRIDINE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-5-fluoro-4-iodopyridine 884494-49-9
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Dideu Industries Group Limited

Product: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE 884494-49-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-01

Career Henan Chemical Co

Product: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE 884494-49-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-01

884494-49-9, 2-CHLORO-5-FLUORO-4-IODOPYRIDINERelated Search:

Cyhalothrin 2-CHLORO-5-FLUORO-4-IODO-3-PICOLINE 3-FLUORO-4-IODOPYRIDINE 2-CHLORO-5-FLUORO-4-IODOPYRIDINE 2-Chloro-4-iodopyridine

2-Chloro-5-fluoro-4-iodopyridine 98%

2-Chloro-5-Fluoro-4-Iodopyridine98%

Pyridine, 2-chloro-5-fluoro-4-iodo-

Methyl 7-bromopicolinate

2-CHLORO-5-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH

2-CHLORO-5-FLUORO-4-IODOPYRIDINE

884494-49-9

Fluorine series