4-Fluoro-1H-pyrazole

Product Name: 4-Fluoro-1H-pyrazole
CAS No.: 35277-02-2
Chemical Name: 4-Fluoro-1H-pyrazole
Synonyms: 4-Fluropyrazole;4-Fluoro-1H-pyrazole;1H-Pyrazole, 4-fluoro-;4-Fluoro-1H-pyrazole 95%;4-Fluoro-1H-pyrazole;4-Fluoro-1H-pyrazole/4-Fluoropyrazole;4-Fluoro-1H-pyrazole4-Fluoro-1H-pyrazole
CBNumber: CB31481942
Molecular Formula: C3H3FN2
Formula Weight: 86.07
MOL File: 35277-02-2.mol

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4-Fluoro-1H-pyrazole Property

Melting point:: 38-40 °C
Boiling point:: 193℃
Density: 1.320
Flash point:: 70℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 13.66±0.50(Predicted)
form: low melting solid
color: Colourless to off-white
InChI: InChI=1S/C3H3FN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
InChIKey: RYXJXPHWRBWEEB-UHFFFAOYSA-N
SMILES: N1C=C(F)C=N1

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Safety

WGK Germany: WGK 3
HS Code: 2933199090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 747858
Product name: 4-Fluoro-1H-pyrazole
Purity: 95%
Packaging: 250MG
Price: $183
Updated: 2026/03/19

TRC

Product number: F597945
Product name: 4-Fluoropyrazole
Packaging: 1g
Price: $440
Updated: 2021/12/16

Apolloscientific

Product number: PC520591
Product name: 4-Fluoro-1H-pyrazole
Purity: 98%
Packaging: 250mg
Price: $46
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-3-60
Product name: 4-Fluoro-1H-pyrazole
Packaging: 250mg
Price: $74
Updated: 2021/12/16

Matrix Scientific

Product number: 077061
Product name: 4-Fluoro-1H-pyrazole
Purity: 95+%
Packaging: 250mg
Price: $115
Updated: 2021/12/16

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4-Fluoro-1H-pyrazole Chemical Properties,Usage,Production

Uses

4-Fluoropyrazole is used in preparation and palladium catalyzed cross-coupling reactions of tributylstannyl fluoropyrazole.

Synthesis

761-88-6

35277-02-2

General procedure for the synthesis of 4-fluoro-1H-pyrazole using the compound (CAS: 761-88-6) as starting material: dihydrazine (4.48 g, 0.043 mol) was added to (Z)-3-(dimethylamino)-2-fluoroacrylaldehyde (5 g, 0.043 mol) in 100 mL of 40% (V/V) aqueous ethanol solution. Subsequently, the reaction mixture was heated at 55 °C for 30 min. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with saturated aqueous sodium bicarbonate to 9. The aqueous layer was extracted with ether and the organic layers were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by distillation under reduced pressure to give 3.6 g of the title compound 28-d as a yellow oil in 77% yield.

References

[1] Patent: WO2013/40790, 2013, A1. Location in patent: Page/Page column 87; 88
[2] Patent: WO2013/43624, 2013, A1. Location in patent: Page/Page column 87; 88

4-Fluoro-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoro-1H-pyrazole Suppliers

China 163 India 7 Switzerland 1 United Kingdom 2 United States 8 Global 181

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View Lastest Price from 4-Fluoro-1H-pyrazole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Fluoro-1H-pyrazole 35277-02-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 500kgs/month
Release date: 2021-10-28

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Fluoro-1H-pyrazole 35277-02-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-19

Nanjing Fred Technology Co., Ltd

Product: 4-Fluoro-1H-pyrazole 35277-02-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-02

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