4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER
- Product Name
- 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER
- CAS No.
- 175596-01-7
- Chemical Name
- 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER
- Synonyms
- 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER
- CBNumber
- CB31484877
- Molecular Formula
- C9H6FNO2
- Formula Weight
- 179.15
- MOL File
- 175596-01-7.mol
4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER Property
- Boiling point:
- 296.0±30.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- color
- White to off-white
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M338343
- Product name
- Methyl4-Cyano-2-fluorobenzoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 9198AA
- Product name
- Methyl4-cyano-2-fluorobenzoate
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 9198AA
- Product name
- Methyl4-cyano-2-fluorobenzoate
- Packaging
- 100mg
- Price
- $20
- Updated
- 2021/12/16
- Product number
- FC67185
- Product name
- 4-Cyano-2-fluorobenzoic acid methyl ester
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC500686
- Product name
- Methyl4-cyano-2-fluorobenzoate
- Packaging
- 5g
- Price
- $92
- Updated
- 2021/12/16
4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
164149-28-4
74-88-4
175596-01-7
Step (i) Potassium carbonate (3.70 g, 26.7 mmol) was added to a solution of 4-cyano-2-fluorobenzoic acid (4 g, 24.3 mmol) in N,N-dimethylformamide (DMF, 350 mL). After stirring for 15 min at room temperature, iodomethane (1.66 mL, 26.7 mmol) was slowly added. The reaction vial was sealed and the reaction mixture was stirred at 40 °C for 2 hours. Upon completion of the reaction, most of the DMF was removed by distillation under reduced pressure. the residue was subjected to liquid-liquid partitioning with dichloromethane (DCM, 50 mL) and saturated saline (50 mL). The organic phase was separated and filtered through a short column of silica gel to remove possible solid impurities. Finally, the organic phase was concentrated under reduced pressure to afford methyl 4-cyano-2-fluorobenzoate (4.1 g, 94% yield). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) δ ppm: 3.96 (s, 3H), 7.44-7.48 (m, 1H), 7.49-7.53 (m, 1H), 8.01-8.05 (m, 1H).
References
[1] Patent: WO2015/25164, 2015, A1. Location in patent: Page/Page column 81-82
[2] Patent: US2015/57298, 2015, A1. Location in patent: Paragraph 0551
[3] Patent: US2016/207883, 2016, A1. Location in patent: Paragraph 0916-0918
[4] Patent: WO2009/124962, 2009, A2. Location in patent: Page/Page column 141
4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER manufacturers
- Product
- 4-Cyano-2-Fluoro-Benzoic Acid Methyl Ester 175596-01-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 50mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-08