2,6-Dibromo-4-tert-butylaniline
- Product Name
- 2,6-Dibromo-4-tert-butylaniline
- CAS No.
- 10546-67-5
- Chemical Name
- 2,6-Dibromo-4-tert-butylaniline
- Synonyms
- 2,6-Dibromo-4-t-butylaniline;4-(tert-Butyl)-2,6-dibromoaniline;4-(tert-Butyl)-2,6-dibromoaniline 98%;2,6-Dibromo-4-(1,1-dimethylethyl)benzenamine;Benzenamine, 2,6-dibromo-4-(1,1-dimethylethyl)-
- CBNumber
- CB31503138
- Molecular Formula
- C10H13Br2N
- Formula Weight
- 307.02
- MOL File
- 10546-67-5.mol
2,6-Dibromo-4-tert-butylaniline Property
- Boiling point:
- 288℃
- Density
- 1.609
- Flash point:
- 128℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.80±0.10(Predicted)
- Appearance
- Colorless to light yellow Solid-Liquid Mixture
- InChI
- InChI=1S/C10H13Br2N/c1-10(2,3)6-4-7(11)9(13)8(12)5-6/h4-5H,13H2,1-3H3
- InChIKey
- FEHTXNYXDWPZCQ-UHFFFAOYSA-N
- SMILES
- C1(N)=C(Br)C=C(C(C)(C)C)C=C1Br
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D424765
- Product name
- 2,6-Dibromo-4-tert-butylaniline
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- D424765
- Product name
- 2,6-Dibromo-4-tert-butylaniline
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR1068
- Product name
- 4-(tert-Butyl)-2,6-dibromoaniline
- Purity
- 98%
- Packaging
- 5g
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 3730-9-11
- Product name
- 4-(tert-Butyl)-2,6-dibromoaniline
- Purity
- 98%
- Packaging
- 5G
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0036975
- Product name
- 2,6-Dibromo-4-(tert-butyl)aniline
- Purity
- 98.18%
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
2,6-Dibromo-4-tert-butylaniline Chemical Properties,Usage,Production
Uses
2,6-Dibromo-4-tert-butylaniline
Synthesis
769-92-6
10546-67-5
The general procedure for the synthesis of 2,6-dibromo-4-tert-butylaniline from 4-tert-butylaniline was as follows: 4-tert-butylaniline (24.2 g, 0.162 mol) was dissolved in 250 mL of acetic acid. A solution of bromine (17 mL, 0.324 mol) in acetic acid (30 mL) was added slowly dropwise to the above solution over a period of 3.5 hours under vigorous stirring. After the dropwise addition was completed, the reaction mixture was heated to 85 °C and maintained for 1.5 hours. After the reaction was completed, it was cooled to room temperature and the mixture was poured into 300 mL of ice water. The resulting mixture was treated with dilute aqueous sodium bicarbonate and 500 mL of ethyl acetate. The organic layer was separated, washed with water and dried with anhydrous sodium sulfate. After concentration, the product was purified by a short silica gel column (with petroleum ether as eluent) to give 44.5 g (89.5% yield) of 2,6-dibromo-4-tert-butylaniline. The structure of the product was confirmed by 1H NMR, 13C NMR and HRMS: 1H NMR (DMSO-d6, 500 MHz, ppm): δ 7.38 (s, 2H, Ar-H), 5.13 (s, 2H, NH2-H), 1.20 (s, 9H, C(CH3)3-H); 13C NMR (DMSO-d6, 125 MHz, ppm): δ 141.46, 140.36, 128.64, 107.68, 33.68, 30.92 ppm. HRMS (ESI): m/z calcd for [M + H+] C10H14Br2N: 307.9407; found: 307.9307.
References
[1] Synthesis, 1995, # 11, p. 1419 - 1422
[2] Tetrahedron, 2009, vol. 65, # 22, p. 4429 - 4439
[3] Chemistry - A European Journal, 2013, vol. 19, # 27, p. 8937 - 8947
[4] Chemistry Letters, 1994, # 11, p. 2127 - 2130
[5] European Journal of Organic Chemistry, 2012, # 7, p. 1448 - 1454
2,6-Dibromo-4-tert-butylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Dibromo-4-tert-butylaniline Suppliers
- Tel
- 18482172240
- 609320203@qq.com
- Country
- China
- ProdList
- 110
- Advantage
- 58
- Tel
- 18526707169
- 40538734@qq.com
- Country
- China
- ProdList
- 34
- Advantage
- 58
- Tel
- 0711-3700636 18827410479
- xujin@boronicgroup.com
- Country
- China
- ProdList
- 42
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55