ecallantide
- Product Name
- ecallantide
- CAS No.
- 460738-38-9
- Chemical Name
- ecallantide
- Synonyms
- DX 88;ecallantide;Cys16-Cys40;Cys32-Cys53);ecallantide USP/EP/BP;H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge:Cys7-Cys57
- CBNumber
- CB31508597
- Molecular Formula
- C305H442N88O91S8
- Formula Weight
- 7053.82798
- MOL File
- 460738-38-9.mol
Safety
- Hazardous Substances Data
- 460738-38-9(Hazardous Substances Data)
ecallantide Chemical Properties,Usage,Production
Description
Ecallantide, also known as DX-88, was approved in 2009 in the United States for treatment of hereditary angioedema (HAE), a condition characterized by episodic attacks of localized edema in cutaneous and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1- 1NH). Mutation of the gene that encodes C1-1NH causes the lack or altered activity of the serine protease, C1-1NH. C1-1NH regulates the kallikrein–kinin (contact activation) and complement cascade systems. Ecallantide (DX-88) was designed to inhibit the action of plasma kallikrein. Ecallantide is a potent and selective inhibitor of plasma kallikrein with a Ki= 25 pM. The discovery program that identified ecallantide used phage display technology and a library of designed variants of the first Kunitz domain of TFPI. Ecallantide, a 60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by 7-amino acids. Ecallantide has been developed as a subcutaneous administered formulation.
Originator
Dyax Corp. (United States)
Uses
Treatment of hereditary angioedema; reduction of blood loss during cardiothoracic surgery (plasma kallikrein inhibitor).
brand name
Kalbitor
ecallantide Preparation Products And Raw materials
Raw materials
Preparation Products
ecallantide Suppliers
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15185
- Advantage
- 58
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- eric@peptidego.com
- Country
- China
- ProdList
- 6527
- Advantage
- 58
- Tel
- 15971444841
- Fax
- 18327183813
- amber@biochempartner.com
- Country
- China
- ProdList
- 3063
- Advantage
- 58
- Tel
- +8618339805032
- alfa4@alfachem.cn
- Country
- China
- ProdList
- 13039
- Advantage
- 58
- Tel
- +86-027-59207850
- Fax
- 86-27-59524646
- info@fortunachem.com
- Country
- China
- ProdList
- 6000
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 27588
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14092
- Advantage
- 58
- Tel
- 0571-88211921 13355716090
- Sales@gotopbio.com
- Country
- China
- ProdList
- 2835
- Advantage
- 58
- Tel
- 18168071971
- support@yuan-peptide.com
- Country
- China
- ProdList
- 2977
- Advantage
- 58
- Tel
- 17711399154
- 3211919385@qq.com
- Country
- China
- ProdList
- 1815
- Advantage
- 58
- Tel
- 0571-88211921 15572296305
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5144
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6130
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- 15888826472@163.com
- Country
- China
- ProdList
- 2729
- Advantage
- 58
- Tel
- 19961912513
- sales@hongtide.com
- Country
- China
- ProdList
- 4580
- Advantage
- 58
- Tel
- 0512-51886999 17706251929
- office@combiosz.com
- Country
- China
- ProdList
- 2223
- Advantage
- 58
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 4904
- Advantage
- 58
- Tel
- 19135651983 19135651983
- 18611134419@163.com
- Country
- China
- ProdList
- 4977
- Advantage
- 58
- Tel
- 0571-85350119 13305819357
- bptsales@163.com
- Country
- China
- ProdList
- 3793
- Advantage
- 58
- Tel
- +852-53358525
- xena@healthtide-api.com
- Country
- China
- ProdList
- 619
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10247
- Advantage
- 58
- Tel
- +8617531972939
- anna@api-made.com
- Country
- China
- ProdList
- 2944
- Advantage
- 58
- Tel
- +undefined17712220823
- admin@guyunchem.com
- Country
- China
- ProdList
- 616
- Advantage
- 58
View Lastest Price from ecallantide manufacturers
- Product
- ecallantide 460738-38-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-11-15
- Product
- Ecallantide 460738-38-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2023-01-12