ecallantide

Product Name: ecallantide
CAS No.: 460738-38-9
Chemical Name: ecallantide
Synonyms: DX 88;ecallantide;Cys16-Cys40;Cys32-Cys53);ecallantide USP/EP/BP;H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge：Cys7-Cys57
CBNumber: CB31508597
Molecular Formula: C305H442N88O91S8
Formula Weight: 7053.82798
MOL File: 460738-38-9.mol

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Safety

Hazardous Substances Data: 460738-38-9(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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ecallantide Chemical Properties,Usage,Production

Description

Ecallantide, also known as DX-88, was approved in 2009 in the United States for treatment of hereditary angioedema (HAE), a condition characterized by episodic attacks of localized edema in cutaneous and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1- 1NH). Mutation of the gene that encodes C1-1NH causes the lack or altered activity of the serine protease, C1-1NH. C1-1NH regulates the kallikrein–kinin (contact activation) and complement cascade systems. Ecallantide (DX-88) was designed to inhibit the action of plasma kallikrein. Ecallantide is a potent and selective inhibitor of plasma kallikrein with a Ki= 25 pM. The discovery program that identified ecallantide used phage display technology and a library of designed variants of the first Kunitz domain of TFPI. Ecallantide, a 60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by 7-amino acids. Ecallantide has been developed as a subcutaneous administered formulation.

Originator

Dyax Corp. (United States)

Uses

Treatment of hereditary angioedema; reduction of blood loss during cardiothoracic surgery (plasma kallikrein inhibitor).

brand name

Kalbitor

ecallantide Preparation Products And Raw materials

Raw materials

Preparation Products

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ecallantide Suppliers

China 27 United States 3 Global 30

Wuxi Zhongkun Biochemical Technology Co., Ltd.

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View Lastest Price from ecallantide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ecallantide 460738-38-9
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

Nantong Guangyuan Chemicl Co,Ltd

Product: ecallantide 460738-38-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-15

460738-38-9, ecallantideRelated Search:

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ecallantide

DX 88

ecallantide USP/EP/BP

Cys16-Cys40

Cys32-Cys53)

H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge：Cys7-Cys57

460738-38-9

C305H442N88O91S8