1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester

Product Name: 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester
CAS No.: 136944-79-1
Chemical Name: 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester
Synonyms: MFCD09473436;methyl 4-iodo-1H-pyrazole-5-carboxylate;4-Iodo-1H-pyrazole-3-carboxylic acid methyl ester;1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester
CBNumber: CB31509206
Molecular Formula: C5H5IN2O2
Formula Weight: 252.01
MOL File: 136944-79-1.mol

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1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester Property

Boiling point:: 338.5±22.0 °C(Predicted)
Density: 2.083±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
pka: 10.03±0.50(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M324575
Product name: methyl4-iodo-1H-pyrazole-3-carboxylate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 6533AA
Product name: Methyl4-iodo-1H-pyrazole-3-carboxylate
Packaging: 250mg
Price: $199
Updated: 2021/12/16

Matrix Scientific

Product number: 159613
Product name: Methyl 4-iodo-1H-pyrazole-5-carboxylate
Packaging: 0.500g
Price: $240
Updated: 2021/12/16

Matrix Scientific

Product number: 159613
Product name: Methyl 4-iodo-1H-pyrazole-5-carboxylate
Packaging: 1g
Price: $300
Updated: 2021/12/16

AK Scientific

Product number: 6533AA
Product name: Methyl4-iodo-1H-pyrazole-3-carboxylate
Packaging: 1g
Price: $319
Updated: 2021/12/16

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1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester Chemical Properties,Usage,Production

Synthesis

15366-34-4

136944-79-1

Methyl 1H-pyrazole-3-carboxylate (0.5 g, 4.3 mmol, 1.1 eq.) and N-iodosuccinimide (NIS) (0.97 g, 3.9 mmol, 1 eq.) were dissolved in acetonitrile (15 mL), and trifluoroacetic acid (0.1 mL) was added as a catalyst. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was concentrated to remove the solvent. The concentrated residue was partitioned between ethyl acetate (EtOAc) and 5% aqueous sodium bicarbonate (NaHCO3). The organic layer was separated, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Finally, the residue was purified by silica gel column chromatography to afford the target product methyl 4-iodo-1H-pyrazole-3-carboxylate (0.61 g, 61% yield).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 1, p. 159 - 166
[2] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00315
[3] Russian Chemical Bulletin, 2010, vol. 59, # 8, p. 1549 - 1555

1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester manufacturers

Career Henan Chemical Co

Product: 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester 136944-79-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-19

136944-79-1, 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl esterRelated Search:

1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester

4-Iodo-1H-pyrazole-3-carboxylic acid methyl ester

methyl 4-iodo-1H-pyrazole-5-carboxylate

MFCD09473436

136944-79-1