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(D-ALA7)-ANGIOTENSIN I/II (1-7)

Product Name
(D-ALA7)-ANGIOTENSIN I/II (1-7)
CAS No.
159432-28-7
Chemical Name
(D-ALA7)-ANGIOTENSIN I/II (1-7)
Synonyms
DA-7;A-779;DRVYIHA;A 779 TFA;A 779(3TFA);A 779?, >98%;A-779 ，E0039;ASP-ARG-VAL-TYR-ILE-HIS-D-ALA;(D-ALA7)-ANGIOTENSIN I/II (1-7);(D-Ala?)-Angiotensin I/II (1-7)
CBNumber
CB3151299
Molecular Formula
C39H60N12O11
Formula Weight
872.97
MOL File
159432-28-7.mol
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(D-ALA7)-ANGIOTENSIN I/II (1-7) Property

Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
-15°C
pka
3.29±0.10(Predicted)
form 
lyophilized powder
color 
white to off-white
Water Solubility 
≥ 29.1mg/mL in Water with gentle warming
Sequence
Asp-Arg-Val-Tyr-Ile-His-{d-Ala}
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Safety

HS Code 
2933.29.4300
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1370
Product name
A-779 trifluoroacetate salt
Purity
≥98% (HPLC)
Packaging
5MG
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1370
Product name
A-779 trifluoroacetate salt
Purity
≥98% (HPLC)
Packaging
25MG
Price
$462
Updated
2025/07/31
TCI Chemical
Product number
A3281
Product name
A-779
Packaging
25MG
Price
$151
Updated
2025/07/31
TCI Chemical
Product number
A3281
Product name
A-779
Packaging
100MG
Price
$416
Updated
2025/07/31
Cayman Chemical
Product number
23396
Product name
A-779
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2021/12/16
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(D-ALA7)-ANGIOTENSIN I/II (1-7) Chemical Properties,Usage,Production

Uses

A 779 is an angiotensin heptapeptide analog antagonist.

Biochem/physiol Actions

A-779 (D-Ala7-Ang-(1-7)) is a potent and selective antagonist of angiotensin (1-7), an endogenous peptide that acts through activation of a non-AT1, non-AT2 receptor, Mas, and opposes the activity of angiotensin. A-779 has an IC50 of 0.3 nM for Mas with negligible affinity for either AT1R or AT2R.

in vivo

Infusion of Ang(1-7) and A-779 (400 ng/kg/min, s.c.) alone or combined for 6 weeks does not prevent uterus atrophy or inhibit the body weight gain of OVX rats. A-779 markedly elevates serum bone specific alkaline phosphatase (BALP), telopeptides of collagen type I (CTX), tartarate resistant acid phosphatase (TRAcP 5b), osteocalcin (OC) and urinary deoxypyridinoline (DPD). Infusion of Ang(1-7) and/or A-779 does not significantly change serum minerals concentrations in sham or OVX groups. A-779 in the OVX animals does not change AngII, Ang(1-7), AT1R, AT2R, ACE, ACE-2, Mas receptor, RANKL and OPG proteins expressions in relation to OVX group, while AngII (P < 0.05), AT1R (P < 0.05), ACE (P < 0.01) and RANKL (P < 0.01) expressions are significantly higher and Ang(1-7), AT2R, ACE-2, MasR and OPG are significantly (P < 0.01) lower than sham group. Blocking of the G-protein coupled receptor (Mas) by A-779 markedly abolishes Ang(1-7) favorable effects on bone health suggesting the vital role of Mas receptor in mediating Ang(1-7) osteo-protective effects[1]. Inhibition of Ang1-7 cascade by A-779 (400 ng/kg/min) significantly eradicates captopril protective effects on bone metabolism, mineralization and micro-structure. A-779 also restores OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade and down-regulates OPG expression and ACE-2/Ang1-7/Mas pathway[2].

IC 50

AT2 Receptor; AT1 Receptor

storage

Store at -20°C

(D-ALA7)-ANGIOTENSIN I/II (1-7) Preparation Products And Raw materials

Raw materials

Preparation Products

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(D-ALA7)-ANGIOTENSIN I/II (1-7) Suppliers

Americas 1 China 91 Europe 1 Germany 1 India 1 Japan 1 The Netherlands 1 United Kingdom 2 United States 15 USA 1 Global 115
GL Biochem (Shanghai) Ltd
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+86-25-83453306
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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159432-28-7, (D-ALA7)-ANGIOTENSIN I/II (1-7)Related Search:

Angiotensin (D-ALA7)-ANGIOTENSIN I/II (1-7) H-ALA-ALA-D-ALA-OH ASP-ARG-VAL-TYR-ILE-HIS-DPRO

  • A-779
  • H-ASP-ARG-VAL-TYR-ILE-HIS-D-ALA-OH
  • DRVYIHA
  • (D-ALA7)-ANGIOTENSIN I/II (1-7)
  • ASP-ARG-VAL-TYR-ILE-HIS-D-ALA
  • (D-Ala7)-Angiotensin I/II (1-7) A-779
  • A 779(3TFA)
  • A 779,Asp-Arg-Val-Tyr-Ile-His-d-Ala,DRVYIHd-ALA, >98%
  • A 779?, >98%
  • 1-7-Angiotensin II, 5-L-isoleucine-7-D-alanine-
  • Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH
  • 5-L-Isoleucine-7-D-Alanine-1-7-Angiotensin II
  • DA-7
  • A 779 TFA(159432 28 7 free base),A 779 TFA(159432287 free base)
  • A 779 TFA(159432-28-7 free base)
  • A 779，Asp-Arg-Val-Tyr-Ile-His-d-Ala，DRVYIH{d-ALA}
  • Asp-Arg-Val-Tyr-Ile-His-d-Ala，DRVYIH{d-ALA}
  • (D-Ala?)-Angiotensin I/II (1-7)
  • A 779 TFA
  • (2R,5S,8S,11S,14S,17S,20S)-5-((1H-Imidazol-4-yl)methyl)-20-amino-8-((S)-sec-butyl)-17-(3-guanidinopropyl)-11-(4-hydroxybenzyl)-14-isopropyl-2-methyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadocosanedioic acid
  • A 779, angiotensin-(1-7) antagonist
  • A-779 ，E0039
  • 159432-28-7
  • C39H60N12O11