5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE
- Product Name
- 5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE
- CAS No.
- 823221-93-8
- Chemical Name
- 5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE
- Synonyms
- 5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 5-broMo-2-chloro-4-(trifluoroMethyl)-
- CBNumber
- CB31515665
- Molecular Formula
- C6H2BrClF3N
- Formula Weight
- 260.44
- MOL File
- 823221-93-8.mol
5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE Property
- Melting point:
- 11-13 °C
- Boiling point:
- 80-81 °C(Press: 16 Torr)
- Density
- 1.813 g/cm3
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- pka
- -3.73±0.10(Predicted)
- color
- Clear, yellow
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B690908
- Product name
- 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B690908
- Product name
- 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- PC49632
- Product name
- 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 3H32-F-07
- Product name
- 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 032367
- Product name
- 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production
Uses
5-Bromo-2-chloro-4-(trifluoromethyl)pyridine is an organic compound mainly used as a pharmaceutical intermediate, especially for the synthesis of certain drugs.
Synthesis
680-15-9
401892-47-5
823221-93-8
To a stirred solution of 5-bromo-2-chloro-4-iodopyridine (20.0 g, 63.09 mmol, 1.0 eq.) in N,N-dimethylformamide (DMF, 200 mL) at room temperature and under argon protection was added sequentially methyl 2,2-difluoro-2-(fluorosulfonyl)acetate (16.15 mL, 126.18 mmol, 2.0 eq.) and iodide cuprous iodide (CuI, 24.02 g, 126.18 mmol, 2.0 equiv). The reaction mixture was heated to 100 °C with continuous stirring for 6 hours. The reaction progress was monitored by thin layer chromatography (TLC) and non-polar spots were observed. After completion of the reaction, the mixture was diluted with water (200 mL), filtered and washed sequentially with n-pentane (1 L) and cold water (3 L). The organic layer was separated and dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure at 30 °C. The crude product was purified by silica gel column chromatography (100-200 mesh) with petroleum ether solution of 5% ethyl acetate as eluent to afford the target product 5-bromo-2-chloro-4-trifluoromethylpyridine (9.0 g, yield 55.2%) as a liquid compound.TLC conditions: petroleum ether solution of 5% ethyl acetate; Rf value: 0.7.
References
[1] Patent: WO2017/147700, 2017, A1. Location in patent: Paragraph 00355
[2] Patent: WO2017/147701, 2017, A1. Location in patent: Paragraph 00320; 00322-00323
5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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