(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE

Product Name: (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE
CAS No.: 101376-26-5
Chemical Name: (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE
Synonyms: (4-Benzyl-3-morpholinyl)methanol;(R)-(4-BenzylMorpholin-3-yl)Methanol;[(3R)-4-benzylMorpholin-3-yl]Methanol;(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE;(R)-4-Benzyl-3-hydroxymethyloorpholine;(R)-4-Benzly-3-hydroxymethylmorpholine;(R)-4-(phenylmethyl)-3-Morpholinemethanol;(3R)-4-(Phenylmethyl)-3-morpholinemethanol;3-Morpholinemethanol, 4-(phenylmethyl)-, (3R)-
CBNumber: CB31519269
Molecular Formula: C12H17NO2
Formula Weight: 207.27
MOL File: 101376-26-5.mol

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(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE Property

Melting point:: 229-230 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
Boiling point:: 322.7±22.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.85±0.10(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B535668
Product name: (R)-(4-Benzylmorpholin-3-yl)methanol
Packaging: 50mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142893
Product name: (R)-(4-Benzylmorpholin-3-yl)methanol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142893
Product name: (R)-(4-Benzylmorpholin-3-yl)methanol
Packaging: 250mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: Z3804
Product name: (R)-(4-Benzylmorpholin-3-yl)methanol
Packaging: 250mg
Price: $127
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142893
Product name: (R)-(4-Benzylmorpholin-3-yl)methanol
Packaging: 500mg
Price: $210
Updated: 2021/12/16

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(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE Chemical Properties,Usage,Production

Uses

(R)-4-Benzyl-3-hydroxymethylmorpholine is used in the synthesis and research of chiral medicines.

Synthesis

106973-37-9

101376-26-5

General procedure for the synthesis of (R)-(4-benzyl-3-morpholine)-methanol from (S)-4-benzyl-5-oxo-3-morpholinecarboxylic acid: to a solution of intermediate 66 ((S)-4-benzyl-5-oxo-3-morpholinecarboxylic acid, 12.6 g, 53.6 mmol) in tetrahydrofuran (200 mL) was slowly added the borane-tetrahydrofuran complex (1.0 M. 348mL). The reaction mixture was stirred at room temperature for 6 hours before the reaction was quenched by the addition of methanol, followed by heating to 80 °C and continued stirring for 2 hours. Upon completion of the reaction, the mixture was extracted by adding saturated aqueous sodium bicarbonate and ethyl acetate to the mixture. The aqueous layer was extracted again with ethyl acetate and the organic layers were combined. The organic layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 90/10 to 10/90 gradient elution) to afford the target product (R)-(4-benzyl-3-morpholine)-methanol (9.60 g, 46.0 mmol, 86% yield). Mass spectrometry (ESI+) showed the molecular ion peak m/z 208 ([M+H]+, 100%).

References

[1] Patent: WO2011/111875, 2011, A1. Location in patent: Page/Page column 90-91
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2577 - 2580
[3] Helvetica Chimica Acta, 2004, vol. 87, # 1, p. 90 - 105

(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE Suppliers

China 78 Germany 1 India 1 United Kingdom 2 United States 8 Global 90

J & K SCIENTIFIC LTD.

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ForeChem (Nantong) Technology Co.,Ltd.

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View Lastest Price from (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: (R)-(4-Benzylmorpholin-3-yl)methanol 101376-26-5
Price: US $0.00/g
Min. Order: 10g
Purity: 0.99
Supply Ability: 5kg
Release date: 2023-09-15

Wuhan Monad Medicine Tech Co.,LTD

Product: (4-Benzyl-3-morpholinyl)methanol 101376-26-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 20000
Release date: 2020-12-17

Hebei shuoxi biotechnology co. LTD

Product: (R)-(4-Benzylmorpholin-3-yl)methanol 101376-26-5
Price: US $0.00/KG
Min. Order: 1g
Purity: 99.9%
Supply Ability: 1 ton
Release date: 2019-10-28

101376-26-5, (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINERelated Search:

Benzyltriethylammonium chloride 4-BENZYL-3-HYDROXYMETHYLMORPHOLINE methyl 4-benzylmorpholine-3-(S)-carboxylate 4-BENZYL-3(S)-MORPHOLINECARBOXYLIC ACID (S)-4-Benzyl-5-oxomorpholine-3-carboxylic acid (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE (S)-ETHYL 4-BENZYL-5-OXO-MORPHOLINE-3-CARBOXYLATE

(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE

(3R)-4-(Phenylmethyl)-3-morpholinemethanol

(R)-4-Benzly-3-hydroxymethylmorpholine

(R)-4-Benzyl-3-hydroxymethyloorpholine

(R)-(4-BenzylMorpholin-3-yl)Methanol

[(3R)-4-benzylMorpholin-3-yl]Methanol

(R)-4-(phenylmethyl)-3-Morpholinemethanol

3-Morpholinemethanol, 4-(phenylmethyl)-, (3R)-

(4-Benzyl-3-morpholinyl)methanol

101376-26-5