1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE

Product Name: 1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE
CAS No.: 398495-65-3
Chemical Name: 1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE
Synonyms: 1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE;Ethyl 5-Boc-3-amino-5,6-dihydropyrrolo[3,4-c]pyrazole-1(4H)-carboxylate;5-tert-butyl 1-ethyl 3-aMinopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate;5-Boc-3-Amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester;5-tert-butyl 1-ethyl 3-aMino-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylate;5-(tert-Butyl) 1-ethyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate;5-O-tert-butyl 1-O-ethyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate;Ethyl 5-(tert-butoxycarbonyl)-3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1-carboxylate;3-Amino-5-tert-butyloxycarbonyl-1-ethoxycarbonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole;3-Amino-5-((tert-butoxy)carbonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester
CBNumber: CB31519360
Molecular Formula: C13H20N4O4
Formula Weight: 296.32
MOL File: 398495-65-3.mol

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1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE Property

Boiling point:: 453.4±55.0 °C(Predicted)
Density: 1.36
storage temp.: 2-8°C(protect from light)
pka: 2.44±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB142369
Product name: 5-tert-Butyl 1-ethyl 3-aminopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate
Packaging: 50mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142369
Product name: 5-tert-Butyl 1-ethyl 3-aminopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate
Packaging: 100mg
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142369
Product name: 5-tert-Butyl 1-ethyl 3-aminopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate
Packaging: 250mg
Price: $225
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142369
Product name: 5-tert-Butyl 1-ethyl 3-aminopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate
Packaging: 500mg
Price: $350
Updated: 2021/12/16

Matrix Scientific

Product number: 072514
Product name: 5-Boc-3-amino-4,6-dihydropyrrolo[3,4-c]-pyrazole-1-carboxylic acid ethyl ester
Purity: 95+%
Packaging: 250mg
Price: $445
Updated: 2021/12/16

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1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE Chemical Properties,Usage,Production

Synthesis

398491-59-3

541-41-3

398495-65-3

The general procedure for the synthesis of ethyl 5-Boc-3-amino-4,6-dihydropyrrolo[3,4-C]pyrazole-1-carboxylate from 3-amino-5-Boc-pyrrolo[3,4-C]pyrazole and ethyl chloroformate was carried out as follows: a solution of THF (250 mL) with ethyl chloroformate (8.9 mL, 93 mmol) was slowly added at 0-5 °C to the solution containing 3 -amino-5-tert-butoxycarbonyl-pyrrolo[3,4-C]pyrazole (20 g, 89 mmol) and diisopropylethylamine (DIEA, 92 mL, 528 mmol) to a solution of THF (500 mL). The reaction was kept at the same temperature for 2 h, followed by raising to room temperature and stirring overnight. After completion of the reaction, the mixture was concentrated to dryness under vacuum. The resulting residue was extracted with ethyl acetate and water, the organic phase was separated, dried over anhydrous sodium sulfate and concentrated again to dryness. The crude product was purified by fast column chromatography (eluent: ethyl acetate/cyclohexane, ratio tapered from 4/6 to 7/3) to afford 19 g (72% yield) of the target compound ethyl 5-Boc-3-amino-4,6-dihydropyrrolo[3,4-C]pyrazole-1-carboxylate as a white solid.1H-NMR (400 MHz, DMSO-d6) δ: 10.06 (s, broad peak, 2H), 4.4-4.05 (m, 6H), 1.27 (t, 3H), 1.00 (s, 9H).

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 8, p. 3080 - 3084
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 1084 - 1090
[3] Patent: WO2004/80457, 2004, A1. Location in patent: Page/Page column 28-29
[4] Patent: US2003/171357, 2003, A1
[5] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 14, p. 4273 - 4278

1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE Suppliers

China 43 India 2 United Kingdom 1 United States 6 Global 52

Beijing Ouhe Technology Co., Ltd

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ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD

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View Lastest Price from 1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE manufacturers

Shanghai Rlavie Technology Co ltd

Product: 5-Boc-3-Amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester 398495-65-3
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 97%minHPLC
Supply Ability: 50kgs/month
Release date: 2021-11-19

398495-65-3, 1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLERelated Search:

5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester 1-ETHYLOXYCARBONYL-3-[4-(4-METHYL-PIPERAZIN-1-YL)-BENZOYLAMINO]-5-BOC-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE 1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE

1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE

3-Amino-5-((tert-butoxy)carbonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester

5-Boc-3-Amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester

Ethyl 5-Boc-3-amino-5,6-dihydropyrrolo[3,4-c]pyrazole-1(4H)-carboxylate

5-(tert-Butyl) 1-ethyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate

3-Amino-5-tert-butyloxycarbonyl-1-ethoxycarbonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole

Ethyl 5-(tert-butoxycarbonyl)-3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1-carboxylate

5-tert-butyl 1-ethyl 3-aMino-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylate

5-tert-butyl 1-ethyl 3-aMinopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate

Pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid, 3-amino-4,6-dihydro-, 5-(1,1-dimethylethyl) 1-ethyl ester

5-O-tert-butyl 1-O-ethyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate

398495-65-3