5,6-dichloronicotinonitrile
- Product Name
- 5,6-dichloronicotinonitrile
- CAS No.
- 65189-15-3
- Chemical Name
- 5,6-dichloronicotinonitrile
- Synonyms
- 5-10g;5,6-dichloronicotinonitrile;2,3-Dichloro-5-cyanopyridine;5,6-dichloropyridine-3-carbonitrile;3-Pyridinecarbonitrile, 5,6-dichloro-
- CBNumber
- CB31536936
- Molecular Formula
- C6H2Cl2N2
- Formula Weight
- 173
- MOL File
- 65189-15-3.mol
5,6-dichloronicotinonitrile Property
- Melting point:
- 146-148°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H2Cl2N2/c7-5-1-4(2-9)3-10-6(5)8/h1,3H
- InChIKey
- JBMLYEZUHCZNKT-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(Cl)C=C1C#N
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H225Highly Flammable liquid and vapour
H304May be fatal if swallowed and enters airways
H314Causes severe skin burns and eye damage
H336May cause drowsiness or dizziness
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P242Use only non-sparking tools.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P281Use personal protective equipment as required.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P331Do NOT induce vomiting.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- D475980
- Product name
- 5,6-dichloropyridine-3-carbonitrile
- Packaging
- 250mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FD167860
- Product name
- 5,6-Dichloronicotinonitrile
- Packaging
- 1g
- Price
- $270
- Updated
- 2021/12/16
- Product number
- 047382
- Product name
- 5,6-Dichloronicotinonitrile
- Purity
- >95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FD167860
- Product name
- 5,6-Dichloronicotinonitrile
- Packaging
- 2g
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 9977AB
- Product name
- 5,6-Dichloronicotinonitrile
- Packaging
- 250mg
- Price
- $128
- Updated
- 2021/12/16
5,6-dichloronicotinonitrile Chemical Properties,Usage,Production
Synthesis
75291-84-8
65189-15-3
General procedure for the synthesis of 5,6-dichloronicotinonitrile from 5,6-dichloronicotinamide: 5,6-dichloronicotinamide (8.4 g, 44 mmol) was suspended in 76 mL of thionyl chloride. The reaction mixture was stirred under reflux conditions for 72 hours. Upon completion of the reaction, the solvent was removed by vacuum concentration and the residue was dissolved in chloroform. The organic layer was washed with water and dried with anhydrous sodium sulfate. After removal of the solvent by concentration under reduced pressure, the crude product was first purified by reversed-phase column chromatography (eluent: acetonitrile/dichloromethane), followed by crystallization in ethyl acetate to afford the target product, 5,6-dichloronicotinonitrile, in 78% (5.95 g) yield. The structure of the product was confirmed by 1H-NMR (CDCl3): δ = 8.05 (s, 1H), 8.60 (s, 1H).
References
[1] Patent: WO2015/150203, 2015, A1. Location in patent: Page/Page column 74
5,6-dichloronicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
5,6-dichloronicotinonitrile Suppliers
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View Lastest Price from 5,6-dichloronicotinonitrile manufacturers
- Product
- 5,6-dichloronicotinonitrile 65189-15-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26