1-(aminomethyl)cyclopentanol hydrochloride

Product Name: 1-(aminomethyl)cyclopentanol hydrochloride
CAS No.: 76066-27-8
Chemical Name: 1-(aminomethyl)cyclopentanol hydrochloride
Synonyms: cyclopentanol hydrochloride;1-(Aminomethyl)cyclopentanol, HCl;1-(aminomethyl)cyclopentanol hydrochloride;1-(aminomethyl)cyclopentan-1-ol hydrochloride;Cyclopentanol, 1-(aMinoMethyl)-, hydrochloride
CBNumber: CB31541611
Molecular Formula: C6H14ClNO
Formula Weight: 151.63446
MOL File: 76066-27-8.mol

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1-(aminomethyl)cyclopentanol hydrochloride Property

Melting point:: 190℃
storage temp.: Inert atmosphere,Room Temperature
Appearance: Off-white to light brown Solid

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Safety

HS Code: 2922190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A633445
Product name: 1-(Aminomethyl)cyclopentanolHydrochloride
Packaging: 50mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W003998
Product name: 1-(Aminomethyl)cyclopentanolhydrochloride
Packaging: 250mg
Price: $52
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA140144
Product name: 1-(Aminomethyl)cyclopentanol hydrochloride
Packaging: 500mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-W003998
Product name: 1-(Aminomethyl)cyclopentanolhydrochloride
Packaging: 1g
Price: $157
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA140144
Product name: 1-(Aminomethyl)cyclopentanol hydrochloride
Packaging: 2g
Price: $162
Updated: 2021/12/16

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1-(aminomethyl)cyclopentanol hydrochloride Chemical Properties,Usage,Production

Uses

1-(Aminomethyl)cyclopentanol Hydrochloride is used for preparation and inhibition of phenylethanolamine N-methyltransferase. It is also used for preparation of sulfonyl benzimidazole derivatives useful in treatment of diseases-mediated by CB2 receptor.

Synthesis

5117-85-1

76066-27-8

The general procedure for the synthesis of 1-(aminomethyl)cyclopentanol hydrochloride from 1-hydroxycyclopentanecarbonitrile was as follows: to a mixture of cyclopentanone (5.50 g, 65.0 mmol) and ZnBr2 (0.20 g, 8.00 mmol) under cooling in an ice bath, TMSCN (10.0 mL, 73.4 mmol) was slowly added, and the reaction was subsequently stirred at room temperature for mixture for 12 hours. The resulting cyanohydrin solution was slowly added dropwise to a suspension of LiAlH4 (8.34 g, 219 mmol) in THF (30.0 mL) at 0 °C, and the mixture was then heated to reflux for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and water (10.0 mL), 4M NaOH aqueous solution (10.0 mL), and water (10.0 mL) were added slowly and sequentially under vigorous stirring. Insoluble material was removed by filtration through a diatomaceous earth pad, and the organic phase was separated and dried with KOH. The dried organic phase was decanted, dried over Na2SO4, filtered and concentrated. The residue was dissolved in MTBE (100 mL), a dioxane solution (10.0 mL) of 4N HCl was added, and stirred at room temperature for 30 minutes. The resulting white solid precipitate was collected by filtration through a sintered funnel to afford the target product 1-(aminomethyl)cyclopentanol hydrochloride (6.68 g, 68% yield).

References

[1] Patent: US2017/217986, 2017, A1. Location in patent: Paragraph 0564; 0565

1-(aminomethyl)cyclopentanol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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76066-27-8, 1-(aminomethyl)cyclopentanol hydrochlorideRelated Search:

1-(AMINOMETHYL)CYCLOPENTANOL

1-(aminomethyl)cyclopentanol hydrochloride

cyclopentanol hydrochloride

1-(aminomethyl)cyclopentan-1-ol hydrochloride

Cyclopentanol, 1-(aMinoMethyl)-, hydrochloride

1-(Aminomethyl)cyclopentanol, HCl

76066-27-8