ChemicalBook > CAS DataBase List > 5,12-dihydroquinoxalino[2,3-b]quinoxaline

5,12-dihydroquinoxalino[2,3-b]quinoxaline

Product Name
5,12-dihydroquinoxalino[2,3-b]quinoxaline
CAS No.
531-46-4
Chemical Name
5,12-dihydroquinoxalino[2,3-b]quinoxaline
Synonyms
ML-090;Fluoflavine;6,11-dihydroquinoxalino[2,3-b]quinoxaline;5,12-dihydroquinoxalino[2,3-b]quinoxaline;Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-;5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%);NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1
CBNumber
CB31549066
Molecular Formula
C14H10N4
Formula Weight
234.26
MOL File
531-46-4.mol
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5,12-dihydroquinoxalino[2,3-b]quinoxaline Property

Melting point:
>262°C (dec.)
Boiling point:
450.2±28.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly, Heated, Sonicated)
form 
Solid
pka
3.94±0.20(Predicted)
color 
Off-White to Dark Yellow
InChI
InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)
InChIKey
WGKYYZDYHYOKQV-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2)N=C2NC3=C(N=C12)C=CC=C3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S920371
Product name
5,12-DIHYDROQUINOXALINO(2,3-B)QUINOXALINE
Purity
AldrichCPR
Packaging
50MG
Price
$179
Updated
2024/03/01
Cayman Chemical
Product number
15172
Product name
ML-090
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15172
Product name
ML-090
Purity
≥95%
Packaging
25mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
15172
Product name
ML-090
Purity
≥95%
Packaging
50mg
Price
$116
Updated
2024/03/01
TRC
Product number
D451743
Product name
5,12-Dihydroquinoxalino[2,3-b]quinoxaline(~90%)
Packaging
5mg
Price
$60
Updated
2021/12/16
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5,12-dihydroquinoxalino[2,3-b]quinoxaline Chemical Properties,Usage,Production

Description

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ≥ 10 μM) and xanthine oxidase (IC50 = 3.5 μM).

Uses

5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor of?NADPH oxidase 1 (NOX1).

Definition

ChEBI: 6,11-dihydroquinoxalino[2,3-b]quinoxaline is a quinoxaline derivative.

5,12-dihydroquinoxalino[2,3-b]quinoxaline Preparation Products And Raw materials

Raw materials

Preparation Products

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5,12-dihydroquinoxalino[2,3-b]quinoxaline Suppliers

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531-46-4, 5,12-dihydroquinoxalino[2,3-b]quinoxalineRelated Search:


  • 5,12-dihydroquinoxalino[2,3-b]quinoxaline
  • Fluoflavine
  • ML-090
  • 6,11-dihydroquinoxalino[2,3-b]quinoxaline
  • 5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%)
  • Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-
  • NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1
  • 531-46-4