2,6-difluoro-4-methylbenzoic acid
- Product Name
- 2,6-difluoro-4-methylbenzoic acid
- CAS No.
- 1201597-23-0
- Chemical Name
- 2,6-difluoro-4-methylbenzoic acid
- Synonyms
- 2,6-difluoro-4-methylbenzoic acid;Benzoic acid, 2,6-difluoro-4-methyl-;2,6-Difluoro-4-methylbenzoic acid 98%
- CBNumber
- CB31557540
- Molecular Formula
- C8H6F2O2
- Formula Weight
- 172.13
- MOL File
- 1201597-23-0.mol
2,6-difluoro-4-methylbenzoic acid Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- CS-W021528
- Product name
- 2,6-Difluoro-4-methylbenzoicacid
- Packaging
- 100mg
- Price
- $53
- Updated
- 2021/12/16
- Product number
- PC56022
- Product name
- 2,6-Difluoro-4-methylbenzoic acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 2721-3-2P
- Product name
- 2,6-Difluoro-4-methylbenzoic acid
- Packaging
- 250mg
- Price
- $194
- Updated
- 2021/12/16
- Product number
- PC56022
- Product name
- 2,6-Difluoro-4-methylbenzoic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $410
- Updated
- 2021/12/16
- Product number
- Z3965
- Product name
- 2,6-Difluoro-4-methylbenzoicacid
- Packaging
- 1g
- Price
- $471
- Updated
- 2021/12/16
2,6-difluoro-4-methylbenzoic acid Chemical Properties,Usage,Production
Synthesis
1201597-22-9
1201597-23-0
Step C: Synthesis of 2,6-difluoro-4-methylbenzoic acid 1. silver oxide (43.8 g, 0.189 mol), water (200 mL) and sodium hydroxide (33.7 g, 0.842 mol) were added to a flask. 2. 2,6-difluoro-4-methylbenzaldehyde (29.23 g, 0.187 mol) was added in batches over 30 min. 3. intense exothermic phenomena were observed during the reaction and the color of the reaction mixture changed from black to gray. 4. The thick suspension formed was continued to be stirred for 1 hour and subsequently filtered through a Brinell funnel. 5. The filtrate was acidified to pH 2 with concentrated hydrochloric acid to produce a suspension. 6. The precipitate was collected by filtration, dissolved in ether and dried by adding anhydrous sodium sulfate. 7. The dried solution was filtered and concentrated to give a white solid product, 2,6-difluoro-4-methylbenzoic acid (17.0 g, 53% yield). 8. The product was purified by 1H-NHPA and concentrated. 8. The product was characterized by 1H-NMR (500 MHz, d6-DMSO): δ 13.7 (br.s, 1H), 7.02 (d, 2H, J = 9.3 Hz), 2.32 (s, 3H).
References
[1] Patent: WO2010/129208, 2010, A1. Location in patent: Page/Page column 32-33
[2] Patent: WO2009/152072, 2009, A1. Location in patent: Page/Page column 35
2,6-difluoro-4-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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