ethyl 5-phenylthiazole-2-carboxylate
- Product Name
- ethyl 5-phenylthiazole-2-carboxylate
- CAS No.
- 58333-72-5
- Chemical Name
- ethyl 5-phenylthiazole-2-carboxylate
- Synonyms
- ethyl 5-phenylthiazole-2-carboxylate;ethyl 5-phenyl-1,3-thiazole-2-carboxylate;5-phenyl-2-Thiazole carbocylic acid ethyl ester;2-Thiazolecarboxylic acid, 5-phenyl-, ethyl ester
- CBNumber
- CB31561086
- Molecular Formula
- C12H11NO2S
- Formula Weight
- 233.29
- MOL File
- 58333-72-5.mol
ethyl 5-phenylthiazole-2-carboxylate Property
- Melting point:
- 62-63 °C
- Boiling point:
- 369.9±35.0 °C(Predicted)
- Density
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.10±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CHM0118609
- Product name
- ETHYL 5-PHENYLTHIAZOLE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.16
- Updated
- 2021/12/16
- Product number
- 126565
- Product name
- Ethyl5-phenylthiazole-2-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $864
- Updated
- 2021/12/16
- Product number
- A122435
- Product name
- Ethyl5-phenylthiazole-2-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $71
- Updated
- 2021/12/16
- Product number
- A122435
- Product name
- Ethyl5-phenylthiazole-2-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $119
- Updated
- 2021/12/16
- Product number
- A122435
- Product name
- Ethyl5-phenylthiazole-2-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $255
- Updated
- 2021/12/16
ethyl 5-phenylthiazole-2-carboxylate Chemical Properties,Usage,Production
Synthesis
84978-66-5
58333-72-5
General procedure for the synthesis of ethyl 5-phenyl-2-thiazolecarboxylate from ethyl [2-phenyl-2-oxoethyl]amino-2-oxoacetate: To a solution of ethyl [2-phenyl-2-oxoethyl]amino-2-oxoacetate (5.0 g, 21.3 mmol) in trichloromethane (50 mL) was added diphosphorus pentasulfide (9.0 g, 42.6 mmol). The reaction mixture was stirred at 60 °C overnight. Upon completion of the reaction, the reaction mixture was quenched with ice water (100 mL) and subsequently extracted with dichloromethane. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography eluting with appropriate eluent to afford ethyl 5-phenyl-2-thiazolecarboxylate (4.5 g, 90.8% yield). Mass spectrometric analysis (ESI) showed m/z: 234.1 [M + 1].
References
[1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0132; 0135; 0136
[2] Chemical & Pharmaceutical Bulletin, 1982, vol. 30, # 11, p. 4195 - 4198
[3] Patent: EP2533783, 2015, B1. Location in patent: Paragraph 0611-0612
[4] Patent: WO2018/58148, 2018, A1. Location in patent: Paragraph 0257
ethyl 5-phenylthiazole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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