methyl 3,6-dibromopyrazine-2-carboxylate
Application- Product Name
- methyl 3,6-dibromopyrazine-2-carboxylate
- CAS No.
- 13301-04-7
- Chemical Name
- methyl 3,6-dibromopyrazine-2-carboxylate
- Synonyms
- 3,6-dibromopyrazine-2-carboxyL;3, 6-dibromopyrazine-2-methyl formate;Methyl 3,6-broMopyrazine-2-carboxylate;methyl 3,6-dibromopyrazine-2-carboxylate;Methyl 3,6-dibromopyrazine-2-carboxylate 97%;3,6-Dibromo-2-pyrazinecarboxylic acid methyl ester;3,6-dibroMo-pyrazine-2-carboxylic acid Methyl ester;2-Pyrazinecarboxylicacid, 3,6-dibromo-, methyl ester;2,5-Dibromo-3-(methoxycarbonyl)pyrazine, 2,5-Dibromo-3-(methoxycarbonyl)-1,4-diazine
- CBNumber
- CB31561288
- Molecular Formula
- C6H4Br2N2O2
- Formula Weight
- 295.92
- MOL File
- 13301-04-7.mol
methyl 3,6-dibromopyrazine-2-carboxylate Property
- Melting point:
- 66-68℃
- Boiling point:
- 304.6±37.0 °C(Predicted)
- Density
- 2.024
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- -3.85±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C6H4Br2N2O2/c1-12-6(11)4-5(8)9-2-3(7)10-4/h2H,1H3
- InChIKey
- OHKYQPNNVGHVOT-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(Br)=CN=C1Br
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M301193
- Product name
- Methyl3,6-dibromopyrazine-2-carboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 283173
- Product name
- Methyl 3,6-dibromopyrazine-2-carboxylate
- Packaging
- 250mg
- Price
- $336
- Updated
- 2021/12/16
- Product number
- J93158
- Product name
- Methyl3,6-dibromopyrazine-2-carboxylate
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- X3200
- Product name
- Methyl3,6-dibromopyrazine-2-carboxylate
- Packaging
- 5g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- 4H56-9-Z7
- Product name
- Methyl 3,6-dibromopyrazine-2-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
methyl 3,6-dibromopyrazine-2-carboxylate Chemical Properties,Usage,Production
Application
3,6-Dibromopyrazine-2-carboxylate can be used as a synthetic intermediate in pharmaceuticals and chemicals.
Synthesis
6966-01-4
13301-04-7
Step 2: Methyl 3-amino-6-bromopyrazine-2-carboxylate (28.5 g, 120 mmol) was suspended in a mixed aqueous solution of 48% hydrobromic acid (120 mL) and acetic acid (30 mL) and cooled to 0 °C. The solution was then slowly added dropwise over a period of 45 minutes. Subsequently, a solution of bromine (18 mL, 336 mmol) in acetic acid (18 mL) was added slowly and dropwise over 45 minutes. While maintaining the reaction temperature at 0 °C, a solution of sodium nitrite (8.28 g, 420 mmol) in water (15 mL) was added and stirring was continued for 30 min. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, excess bromine was quenched by dropwise addition of 30% aqueous sodium bisulfite solution (180 mL). The resulting precipitate was collected by filtration and purified by silica gel column chromatography using a hexane solution of 10% ethyl acetate as eluent to afford methyl 3,6-dibromopyrazine-2-carboxylate as a white crystalline solid (18 g, 49% yield). Mass spectrum (electrospray ionization) m/z: 294 ([M+H]+).
References
[1] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 84-85
[2] ACS Combinatorial Science, 2011, vol. 13, # 5, p. 449 - 452
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 6, p. 2266 - 2270
[4] ACS Chemical Biology, 2013, vol. 8, # 3, p. 519 - 523
[5] Patent: TWI523856, 2016, B. Location in patent: Paragraph 0068
methyl 3,6-dibromopyrazine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from methyl 3,6-dibromopyrazine-2-carboxylate manufacturers
- Product
- methyl 3,6-dibromopyrazine-2-carboxylate 13301-04-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01