tert-butyl 2-methoxypyridin-3-ylcarbamate
- Product Name
- tert-butyl 2-methoxypyridin-3-ylcarbamate
- CAS No.
- 161117-83-5
- Chemical Name
- tert-butyl 2-methoxypyridin-3-ylcarbamate
- Synonyms
- 3-(Boc-amino)-2-methoxypyridine;Tert-Butyl2-methoxy-3-pyridinylcarbamate;tert-butyl 2-methoxypyridin-3-ylcarbamate;3-(N-tert-butoxycarbonylaMino)-2-Methoxypyridine;CarbaMic acid, (2-Methoxy-3-pyridinyl)-, 1,1-diMethylethyl ester;Carbamic acid, N-(2-methoxy-3-pyridinyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB31561703
- Molecular Formula
- C11H16N2O3
- Formula Weight
- 224.26
- MOL File
- 161117-83-5.mol
tert-butyl 2-methoxypyridin-3-ylcarbamate Property
- Boiling point:
- 276.0±25.0 °C(Predicted)
- Density
- 1.146±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.31±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 071076
- Product name
- tert-Butyl 2-methoxypyridin-3-ylcarbamate
- Purity
- 97%
- Packaging
- 5g
- Price
- $617
- Updated
- 2021/12/16
- Product number
- 8148AA
- Product name
- tert-Butyl(2-methoxypyridin-3-yl)carbamate
- Packaging
- 10g
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CHM0096924
- Product name
- TERT-BUTYL 2-METHOXYPYRIDIN-3-YLCARBAMATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1428.74
- Updated
- 2021/12/16
- Product number
- A362916
- Product name
- tert-Butyl(2-methoxypyridin-3-yl)carbamate
- Purity
- 98+%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- A362916
- Product name
- tert-Butyl(2-methoxypyridin-3-yl)carbamate
- Purity
- 98+%
- Packaging
- 5g
- Price
- $143
- Updated
- 2021/12/16
tert-butyl 2-methoxypyridin-3-ylcarbamate Chemical Properties,Usage,Production
Synthesis
20265-38-7
24424-99-5
161117-83-5
To a 2000 mL three-necked flask was added 2-methoxy-3-aminopyridine (100 g, 0.8 mol, 1.0 equiv), di-tert-butyl dicarbonate (194 g, 0.89 mol, 1.1 equiv) and 1,4-dioxane (1140 mL, 11.4 vol). The reaction mixture was heated to reflux and kept for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC) (Expander: ethyl acetate/petroleum ether = 1:4, Rf of raw material = 0.3, Rf of product = 0.55) until the raw material disappeared completely. After completion of the reaction, the reaction mixture was concentrated to afford tert-butyl 2-methoxypyridine-3-carbamate as a dark colored oil (181 g, 100% yield).1H NMR (400 MHz, DMSO-d6): δ 1.47 (s, 9H), 3.91 (s, 3H), 6.95 (m, 1H), 7.84 (m, 1H), 7.98 (d, J =8.1 Hz, 1H), 8.17 (br s, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6041 - 6045
[2] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5292 - 5296
[3] Patent: US6339097, 2002, B1. Location in patent: Page column 13
[4] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 18, p. 2221 - 2226
[5] Tetrahedron Letters, 1994, vol. 35, # 48, p. 9003 - 9006
tert-butyl 2-methoxypyridin-3-ylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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