7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

Product Name: 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate
CAS No.: 1053656-22-6
Chemical Name: 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate
Synonyms: 7-tert-butyl 2-ethyl 5;7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H);Ethyl 7-Boc-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine-2-carboxylate;7-tert-butyl 2-ethyl 5H,6H,7H,8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylate;Ethyl 7-BOC-3-broMo-5,6,7,8-tetrahydroiMidazo[1,2-a]pyrazine-2-carboxylate;7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate;7-O-tert-butyl 2-O-ethyl 6,8-dihydro-5H-imidazo[1,2-a]pyrazine-2,7-dicarboxylate;5,6-dihydroimidazo(1,2-a)pyrazine-2,7(8h)-dicarboxylic acid 7-tert-butyl 2-ethyl;7-(1,1-Dimethylethyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate;5,6-Dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylic acid 7-tert-butyl 2-ethyl ester
CBNumber: CB31562371
Molecular Formula: C14H21N3O4
Formula Weight: 295.33
MOL File: 1053656-22-6.mol

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7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Property

Boiling point:: 457.7±35.0 °C(Predicted)
Density: 1.24
storage temp.: 2-8°C
pka: 4.06±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C14H21N3O4/c1-5-20-12(18)10-8-16-6-7-17(9-11(16)15-10)13(19)21-14(2,3)4/h8H,5-7,9H2,1-4H3
InChIKey: UQNMISYKKAQDDT-UHFFFAOYSA-N
SMILES: C12=NC(C(OCC)=O)=CN1CCN(C(OC(C)(C)C)=O)C2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B701773
Product name: 7-tert-Butyl2-Ethyl5,6-Dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: X8755
Product name: 7-tert-Butyl2-ethyl5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate
Packaging: 250mg
Price: $146
Updated: 2021/12/16

Matrix Scientific

Product number: 076238
Product name: 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo-[1,2-a]pyrazine-2,7(8H)-dicarboxylate
Purity: 95+%
Packaging: 250mg
Price: $352
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0377343
Product name: 7-TERT-BUTYL 2-ETHYL 5,6-DIHYDROIMIDAZO[1,2-A]PYRAZINE-2,7(8H)-DICARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $505.27
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35031
Product name: 7-tert-Butyl2-ethyl5,6-dihydroimidazo[1,2-α]pyrazine-2,7(8H)-dicarboxylate
Purity: 95+%
Packaging: 1g
Price: $680
Updated: 2021/12/16

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7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

77112-52-8

1053656-22-6

Method A - Step b: Preparation of 7-tert-butyl-2-ethyl-5,6-dihydroimidazo[1,2-a]pyrazine-2-dicarboxylate [0080] In 500 mL of ethanol, ethyl imidazo[1,2-a]pyrazine-2-carboxylate (1 g, 5.2 mmol), di-tert-butyl dicarbonate (Boc2O, 3.0 g, 18 mmol), and 200 mg of 10% Pd/C (50% wetted) were added. The reaction mixture was stirred at room temperature for 24 h under hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent being a solvent mixture of dichloromethane and methanol (CH2Cl2:MeOH = 50:1). Ethyl 7-Boc-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate was finally obtained as a yellow oil (0.973 g, 63% yield). 1H NMR (400 MHz, CDCl3) δ 7.51 (s, 1H), 4.68 (s, 2H), 4.30 (q, J = 7.1 Hz, 2H), 4.00 (t, J = 5.2 Hz, 2H), 3.82 (t, J = 5.2 Hz, 2H), 1.43 (s, 9H), 1.21 (t, J = 7.1 Hz, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 10, p. 2300 - 2304
[2] Patent: WO2014/113191, 2014, A1. Location in patent: Paragraph 0079; 0080
[3] Patent: US2009/186899, 2009, A1. Location in patent: Page/Page column 45-47
[4] Patent: WO2009/90055, 2009, A1. Location in patent: Page/Page column 135

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Suppliers

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View Lastest Price from 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate manufacturers

Career Henan Chemical Co

Product: 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 1053656-22-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

1053656-22-6, 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylateRelated Search:

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7-tert-butyl 2-ethyl 5H,6H,7H,8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylate

5,6-dihydroimidazo(1,2-a)pyrazine-2,7(8h)-dicarboxylic acid 7-tert-butyl 2-ethyl

ENCHEM IMIDAZO[1,2-A]PYRAZINE-2,7(8H)-DICARBOXYLICACID, 5,6-DIHYDRO-, 7-(1,1-DIMETHYLETHYL) 2-ETHYL ESTER 1053656-22-6

7-(1,1-Dimethylethyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

1053656-22-6

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