CUR 61414
- Product Name
- CUR 61414
- CAS No.
- 334998-36-6
- Chemical Name
- CUR 61414
- Synonyms
- CUR 61414;CUR61414,CUR-61414;CUR61414, 10 mM in DMSO;CUR 61414, Hedgehog signaling pathway antagonist;N-((3S,5S)-1-(Benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl)-N-(3-methoxybenzyl)-3,3-dimethylbutanamide;N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-benzamide;N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide;N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide;Butanamide, N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-
- CBNumber
- CB31565488
- Molecular Formula
- C31H42N4O5
- Formula Weight
- 550.69
- MOL File
- 334998-36-6.mol
CUR 61414 Property
- Melting point:
- 35-40°C
- Boiling point:
- 714.1±60.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO: soluble2mg/mL (clear solution, warmed)
- pka
- 8.42±0.10(Predicted)
- form
- powder
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
N-Bromosuccinimide Price
- Product number
- 14931
- Product name
- CUR 61414
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 14931
- Product name
- CUR 61414
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $228
- Updated
- 2024/03/01
- Product number
- 366876
- Product name
- CUR-61414
- Packaging
- 5mg
- Price
- $322
- Updated
- 2021/12/16
- Product number
- 007123
- Product name
- CUR 61414
- Packaging
- 1mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- C835000
- Product name
- CUR61414
- Packaging
- 5mg
- Price
- $340
- Updated
- 2021/12/16
CUR 61414 Chemical Properties,Usage,Production
Description
CUR 61414 is a potent inhibitor of hedgehog-
Chemical Properties
Pale Yellow Solid
Uses
CUR 61414 is a proline derivative as mediator of hedgehog signaling pathways for pharmaceutical and cosmetic uses. CUR 61414 is a Nucleoside analog. CUR 61414 is an antimetabolite antitumor combination Gemcitabine cancer treatment
in vitro
previous study found that cur61414 was able to arrest proliferation of basal cells within the bcc-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells [1].
in vivo
the efficacy of cur61414 against basaloid lesions induced when mice were exposed to uv light. these mice were uv irradiated for 6-9 months, producing many microscopic bcc-like basaloid lesions throughout their skin. results showed that the treatment with cur61414 could cause regression of these lesions, as demonstrated by both x-gal staining and histological analyses. moreover, the regression in the cur61414-treated mice seemed to be the result of massive cell death, becuase a significant increase in apoptotic nuclei was seen in basaloid nests after treatment. in addition, no overt toxicity was observed in the skin surrounding the lesions [1].
IC 50
100-200 nm for hedgehog-induced cellular activity
References
[1] JULIET A WILLIAMS. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 8: 4616-4621. DOI:10.1073/pnas.0732813100
[2] TRACY TANG. Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened.[J]. Clinical Cancer Research, 2011, 17 10: 3378-3387. DOI:10.1158/1078-0432.ccr-10-3370
[3] MOHAMMAD ATHAR. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis.[J]. Cancer research, 2004, 64 20: 7545-7552. DOI:10.1158/0008-5472.can-04-1393
CUR 61414 Preparation Products And Raw materials
Raw materials
Preparation Products
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