2-Methyl-4H-3,1-benzoxazin-4-one
- Product Name
- 2-Methyl-4H-3,1-benzoxazin-4-one
- CAS No.
- 525-76-8
- Chemical Name
- 2-Methyl-4H-3,1-benzoxazin-4-one
- Synonyms
- NSC 10119;NSC 521353;ACETANTHRANIL;AURORA KA-3785;Acetylanthranyl;ACETYL ANTHRANIL;TIMTEC-BB SBB000135;2-METHYL-3,1-BENZOXAZA-4-ONE;2-methyl-3,1-benzoxazin-4-one;2-methyl-4h-1-benzoxazin-4-one
- CBNumber
- CB3163296
- Molecular Formula
- C9H7NO2
- Formula Weight
- 161.16
- MOL File
- 525-76-8.mol
2-Methyl-4H-3,1-benzoxazin-4-one Property
- Melting point:
- 79-82 °C(lit.)
- Boiling point:
- 144-145 °C(Press: 12 Torr)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.84±0.20(Predicted)
- InChI
- InChI=1S/C9H7NO2/c1-6-10-8-5-3-2-4-7(8)9(11)12-6/h2-5H,1H3
- InChIKey
- WMQSKECCMQRJRX-UHFFFAOYSA-N
- SMILES
- N1C2=CC=CC=C2C(=O)OC=1C
- EPA Substance Registry System
- 4H-3,1-Benzoxazin-4-one, 2-methyl- (525-76-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 457752
- Product name
- 2-Methyl-4H-3,1-benzoxazin-4-one
- Purity
- 98%
- Packaging
- 10g
- Price
- $62.9
- Updated
- 2024/03/01
- Product number
- J55474
- Product name
- 2-Methyl-4H-benzo[d][1,3]oxazin-4-one
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CHM0021356
- Product name
- 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $682
- Updated
- 2021/12/16
- Product number
- CHM0021356
- Product name
- 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- CHM0021356
- Product name
- 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1328.25
- Updated
- 2021/12/16
2-Methyl-4H-3,1-benzoxazin-4-one Chemical Properties,Usage,Production
Uses
2-Methyl-4H-3,1-benzoxazin-4-one is a synthetic antimicrobial agent. It belongs to the quinazolinone class of drugs. It has been shown to be effective against Staphylococcus aureus and other bacteria. Quinazolinones are potent inhibitors of bacterial growth and have been used successfully in the treatment of tuberculosis and other infectious diseases. 2-Methyl-4H-3,1-benzoxazin-4-one has also been shown to inhibit the growth of some Gram-negative bacteria, such as Salmonella typhi and Escherichia coli.
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038
Synthesis
In 250 mL of RBF took (0.01 mole or 1.37 gm) anthranilic acid (2-amino benzoic acid) to that added 15 mL of acetic anhydride (excess) with porcelain chips. Reflux the solution at 35-40 ℃ for 50-55 min on heating mantle. TLC was done using EA: n-hexane (1:1) solvent system. Then removed the excess solvent (acetic anhydride) at low pressure using rotatory evaporator, To the remaining solid, added petroleum ether (40-60) to extract the 2-methyl-4H-3,1-benzoxazin-4-one. Repeated petroleum ether step to extract the entire product. After drying of petroleum-ether, the crystals of 2-methyl-4H-3, 1-benzoxazin-4-one was obtained and then it was recrystallized with ethanol8. M.P 80-82℃, Yield 79 %.
2-Methyl-4H-3,1-benzoxazin-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methyl-4H-3,1-benzoxazin-4-one manufacturers
- Product
- 2-Methyl-4H-3,1-benzoxazin-4-one 525-76-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 25kg
- Purity
- 98
- Supply Ability
- 500
- Release date
- 2024-12-17
- Product
- 2-Methyl-4H-3,1-benzoxazin-4-one 525-76-8
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 1000Tons
- Release date
- 2024-07-05
- Product
- 2-Methyl-4H-3,1-benzoxazin-4-one 525-76-8
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03