ChemicalBook > CAS DataBase List > HS014

HS014

Product Name: HS014
CAS No.: 207678-81-7
Chemical Name: HS014
Synonyms: HS014;mc4receptor antagonist;HS 014 trifluoroacetate;M.W. 1563.77 C71H94N20O17S2;Melanocortin 4 Receptor antagonist;(AC-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE;Acetyl-(Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide;Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide;(ACETYL-CYS11-BETA-(2-NAPHTHYL)*-D-ALA14,CYS18)-BET;Acetyl-(Cys11,D-2-Nal14,Cys18)-Beta-MSH (11-22) amide
CBNumber: CB3166949
Molecular Formula: C71H94N20O17S2
Formula Weight: 1563.76
MOL File: 207678-81-7.mol

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HS014 Property

Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: −20°C
form: solid
pka: 4.07±0.10(Predicted)
Water Solubility: Soluble to 1 mg/ml in water
Sequence: Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1831
Product name: HS014
Packaging: 1
Price: $352
Updated: 2021/12/16

Usbiological

Product number: 255468
Product name: HS 014
Packaging: 1mg
Price: $631
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000594
Product name: HS014
Purity: 95.00%
Packaging: 1MG
Price: $743.42
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109249
Product name: Ac-Cys-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2
Packaging: 2mg
Price: $798
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109249
Product name: Ac-Cys-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2
Packaging: 5mg
Price: $1734.8
Updated: 2021/12/16

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HS014 Chemical Properties,Usage,Production

Uses

HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats[1][2][3].

in vivo

The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively^[2].
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate^[4].

IC 50

MC4R

storage

Store at -20°C

References

[1] Schi?th HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82. DOI:10.1038/sj.bjp.0701804
[2] Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285. DOI:10.1007/s00213-005-2166-x
[3] Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93. DOI:10.1006/bbrc.1998.8389

HS014 Preparation Products And Raw materials

Raw materials

Preparation Products

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207678-81-7, HS014Related Search:

HS014 cyclic peptide HS014

AC-CYS-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2

AC-CYS-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2

(AC-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE

(AC-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE

[ACETYL-CYS11, B-(2-NAPHTHYL)-D-ALA14, CYS18]-BETA-MELANOCYTE STIMULATING HORMONE FRAGMENT 11-22

M.W. 1563.77 C71H94N20O17S2

Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) aMide HS014

Ac-Cys-Glu-His-D-Nal(2)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge Cys1-Cys8)

Acetyl-(Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide

Melanocortin 4 Receptor antagonist

Acetyl-(Cys11,D-2-Nal14,Cys18)-Beta-MSH (11-22) amide

MC4 Receptor antagonist, Melanocortin 4 Receptor antagonist

HS014

(ACETYL-CYS11-BETA-(2-NAPHTHYL)*-D-ALA14,CYS18)-BET

[acetyl-cys11, β-(2-naphthyl)-d-ala14, cys18]-β-melanocyte stimulating hormone fragment 11-22

mc4receptor antagonist

(Ac-Cys11,D-Ala(2-naphthyl)14,Cys18)-b-MSH (11-22) amide

L-α-Asparagine, N-acetyl-L-cysteinyl-L-α-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-, cyclic (1→8)-disulfide

Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide

Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) aMide HS014

Acetyl-(Cys11,D-2-Nal1?,Cys1?)-β-MSH (11-22) amide trifluoroacetate salt

Acetyl-(Cys??,D-2-Nal??,Cys??)-β-MSH (11-22) amide trifluoroacetate salt

HS 014 trifluoroacetate

207678-81-7

C71H94N20O17S2

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Pituitary Hormones

Hormones

Melanocyte Stimulating Hormone (MSH)

Cytokines, Growth Factors and Hormones

Melanocortin receptor