ChemicalBook > CAS DataBase List > JC-1

JC-1

Product Name
JC-1
CAS No.
47729-63-5
Chemical Name
JC-1
Synonyms
CBIC2;D 383;NK 1420;CBIC2(3);JC-1 IODIDE;D 383 (DYE);6' - tetrachloro - 1;3' - tetraethylbenzimidazolylcarbocyanine iodide;1,1',3,3'-TETRAETHYL-5,5',6,6'-TETRACHLOROIMIDACARBOCYANINE IODIDE;BIS(5,6-DICHLORO-1,3-DIETHYL-2-BENZIMIDAZOLE)TRIMETHINECYANINE IODIDE
CBNumber
CB3168099
Molecular Formula
C25H27Cl4IN4
Formula Weight
652.22
MOL File
47729-63-5.mol
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JC-1 Property

storage temp. 
-20C
solubility 
DMSO: 5mg/mL
form 
solid
color 
red-orange
Appearance
red-purple solid
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10-21
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420200
Product name
JC-1 - CAS 47729-63-5 - Calbiochem
Packaging
5mg
Price
$491
Updated
2025/07/31
Usbiological
Product number
452847
Product name
JC-1 iodide
Packaging
1mg
Price
$425
Updated
2021/12/16
AK Scientific
Product number
1809AH
Product name
5,6-Dichloro-2-(1-(3-(5,6-dichloro-1,3-diethyl-2-benzimidazolylidene)propenyl))-1,3-diethylbenzimidazoliumiodide
Packaging
10mg
Price
$178
Updated
2021/12/16
Apolloscientific
Product number
BISN0055
Product name
JC-1
Purity
99%
Packaging
5mg
Price
$254
Updated
2021/12/16
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JC-1 Chemical Properties,Usage,Production

Description

JC-1 is a cationic carbocyanine dye that accumulates in the mitochondria of live cells in a potential-dependent manner.


The dye exists as a green-fluorescent monomer at depolarized membranes and low concentrations. At higher concentrations (aqueous solutions above 0.1 µM) and hyperpolarized membranes, the dye forms J-aggregates that exhibit an emission at the orange channel.


Healthy cells have high mitochondrial membrane potential, and the decrease of mitochondrial membrane potential is a marker of the early stage of apoptosis. All this allows the use of changes in the orange/green fluorescence ratio of JC-1 to determine healthy vs. depolarized mitochondria. The orange/green fluorescence ratio of JC-1 depends only on the mitochondrial membrane potential and not on other factors such as the size, shape, and density of mitochondria.

Uses

JC-1 is commonly used to determine mitochondrial membrane potential. It is a cationic carbocyanine dye that is membrane permeable and is often used for flow cytometry and fluorescent microscopy. This dye changes color as the membrane potential increases. At higher potentials, JC-1 forms aggregates, which changes the fluorescence emission color from green to red. Dyes and metabolites.

Definition

ChEBI: 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine iodide is a cyanine dye and an organic iodide salt. It has a role as a fluorochrome. It contains a 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine.

General Description

A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨm in cells, tissues, and isolated mitochondria. It labels mitochondria with high membrane potential orange and mitochondria with low membrane potential green. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. Ideal for detection of collapse of ΔΨm induced by uncouplers of mitochondrial respiration. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications.

Biochem/physiol Actions

Product does not compete with ATP.

storage

-20°C

JC-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JC-1 manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
JC-1 47729-63-5
Price
US $0.00/mg
Min. Order
25mg
Purity
>99.00%
Supply Ability
25mg
Release date
2024-03-29

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  • 1,1',3,3'-TETRAETHYL-5,5',6,6'-TETRACHLOROBENZIMIDAZOLOCARBOCYANINE IODIDE
  • 1,1',3,3'-TETRAETHYL-5,5',6,6'-TETRACHLOROIMIDACARBOCYANINE IODIDE
  • 1H-BENZIMIDAZOLIUM, 5,6-DICHLORO-2-[3-(5,6-DICHLORO-1,3-DIETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-YLIDENE)-1-PROPENYL]-1,3-DIETHYL-, IODIDE
  • 1-DODECYL-2-[(E)-3-(1-DODECYL-3,3-DIMETHYL-1,3-DIHYDRO-2H-INDOL-2-YLIDENE)-1-PROPENYL]-3,3-DIMETHYL-3H-INDOLIUM PERCHLORATE
  • 3H-INDOLIUM, 1-DODECYL-2-[3-(1-DODECYL-1,3-DIHYDRO-3,3-DIMETHYL-2H-INDOL-2-YLIDENE)-1-PROPENYL]-3,3-DIMETHYL-, PERCHLORATE
  • 5,5',6,6'-TETRACHLORO-1,1',3,3'-TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE
  • 5,6-DICHLORO-2-[3-(5,6-DICHLORO-1,3-DIETHYL-2-BENZIMIDAZOLINYLIDENE)PROPENYL]-1,3-DIETHYLBENZIMIDAZOLIUM IODIDE
  • 5,6-DICHLORO-2-[(E)-3-(5,6-DICHLORO-1,3-DIETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-YLIDENE)-1-PROPENYL]-1,3-DIETHYL-3H-BENZIMIDAZOL-1-IUM IODIDE
  • BENZIMIDAZOLIUM, 5,6-DICHLORO-2-[3-(5,6-DICHLORO-1,3-DIETHYL-2-BENZIMIDAZOLINYLIDENE)PROPENYL]-1,3-DIETHYL-, IODIDE
  • BENZIMIDAZOLOCARBOCYANINE IODIDE, 5,5',6,6'-TETRACHLORO-1,1',3,3'-TETRAETHYL-
  • BIS(5,6-DICHLORO-1,3-DIETHYL-2-BENZIMIDAZOLE)TRIMETHINECYANINE IODIDE
  • IMIDACARBOCYANINE IODIDE, 1,1',3,3'-TETRAETHYL-5,5',6,6'-TETRACHLORO-
  • JC-1 IODIDE
  • CBIC2
  • CBIC2(3)
  • D 383
  • D 383 (DYE)
  • NK 1420
  • 5,5’,6,6’-tetrachloro-1,1’,3,3’-tetraethylbenzimidazolylcarbocyanineiodide(jc-1
  • (E)-5,6-Dichloro-2-(3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)prop
  • CBIC2(3) 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide
  • 3' - tetraethylbenzimidazolylcarbocyanine iodide
  • 6' - tetrachloro - 1
  • (E)-5,6-Dichloro-2-(3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)prop-1-en-1-yl)-1,3-diethyl-1H-benzo[d]imidazol-3-ium iodide
  • 47729-63-5
  • C25H27Cl4IN4
  • C25H27Cl4N4I
  • C25H27N4Cl4I
  • Lipophilic and Membrane Probes
  • Alphabetical
  • Fluorescent Indicators and Probes
  • Fluorescent Probes, Labels, Particles and Stains
  • BioChemical
  • Biochemicals and Reagents