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JC-1

Product Name
JC-1
CAS No.
47729-63-5
Chemical Name
JC-1
Synonyms
CBIC2;D 383;NK 1420;CBIC2(3);JC-1 IODIDE;D 383 (DYE);6' - tetrachloro - 1;3' - tetraethylbenzimidazolylcarbocyanine iodide;1,1',3,3'-TETRAETHYL-5,5',6,6'-TETRACHLOROIMIDACARBOCYANINE IODIDE;BIS(5,6-DICHLORO-1,3-DIETHYL-2-BENZIMIDAZOLE)TRIMETHINECYANINE IODIDE
CBNumber
CB3168099
Molecular Formula
C25H27Cl4IN4
Formula Weight
652.22
MOL File
47729-63-5.mol
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JC-1 Property

storage temp. 
-20C
form 
solid
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10-21
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420200
Product name
JC-1 - CAS 47729-63-5 - Calbiochem
Packaging
5mg
Price
$476
Updated
2024/03/01
Usbiological
Product number
452847
Product name
JC-1 iodide
Packaging
1mg
Price
$425
Updated
2021/12/16
AK Scientific
Product number
1809AH
Product name
5,6-Dichloro-2-(1-(3-(5,6-dichloro-1,3-diethyl-2-benzimidazolylidene)propenyl))-1,3-diethylbenzimidazoliumiodide
Packaging
10mg
Price
$178
Updated
2021/12/16
Apolloscientific
Product number
BISN0055
Product name
JC-1
Purity
99%
Packaging
5mg
Price
$254
Updated
2021/12/16
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JC-1 Chemical Properties,Usage,Production

Uses

JC-1 is commonly used to determine mitochondrial membrane potential. It is a cationic carbocyanine dye that is membrane permeable and is often used for flow cytometry and fluorescent microscopy. This dye changes color as the membrane potential increases. At higher potentials, JC-1 forms aggregates, which changes the fluorescence emission color from green to red. Dyes and metabolites.

Definition

ChEBI: 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine iodide is a cyanine dye and an organic iodide salt. It has a role as a fluorochrome. It contains a 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine.

General Description

A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨm in cells, tissues, and isolated mitochondria. It labels mitochondria with high membrane potential orange and mitochondria with low membrane potential green. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. Ideal for detection of collapse of ΔΨm induced by uncouplers of mitochondrial respiration. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications.

Biochem/physiol Actions

Product does not compete with ATP.

storage

-20°C

JC-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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JC-1 Suppliers

China 44 Germany 2 India 1 Japan 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 5 United States 11 Global 68
J & K SCIENTIFIC LTD.
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Xi'an Confluore Biological Technology Co., Ltd.
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+86-156-80926068 +86-15680926068
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Xian confluore Biological Technology Co., Ltd.
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View Lastest Price from JC-1 manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
JC-1 47729-63-5
Price
US $0.00/mg
Min. Order
25mg
Purity
>99.00%
Supply Ability
25mg
Release date
2024-03-29

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  • 1,1',3,3'-TETRAETHYL-5,5',6,6'-TETRACHLOROBENZIMIDAZOLOCARBOCYANINE IODIDE
  • 1,1',3,3'-TETRAETHYL-5,5',6,6'-TETRACHLOROIMIDACARBOCYANINE IODIDE
  • 1H-BENZIMIDAZOLIUM, 5,6-DICHLORO-2-[3-(5,6-DICHLORO-1,3-DIETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-YLIDENE)-1-PROPENYL]-1,3-DIETHYL-, IODIDE
  • 1-DODECYL-2-[(E)-3-(1-DODECYL-3,3-DIMETHYL-1,3-DIHYDRO-2H-INDOL-2-YLIDENE)-1-PROPENYL]-3,3-DIMETHYL-3H-INDOLIUM PERCHLORATE
  • 3H-INDOLIUM, 1-DODECYL-2-[3-(1-DODECYL-1,3-DIHYDRO-3,3-DIMETHYL-2H-INDOL-2-YLIDENE)-1-PROPENYL]-3,3-DIMETHYL-, PERCHLORATE
  • 5,5',6,6'-TETRACHLORO-1,1',3,3'-TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE
  • 5,6-DICHLORO-2-[3-(5,6-DICHLORO-1,3-DIETHYL-2-BENZIMIDAZOLINYLIDENE)PROPENYL]-1,3-DIETHYLBENZIMIDAZOLIUM IODIDE
  • 5,6-DICHLORO-2-[(E)-3-(5,6-DICHLORO-1,3-DIETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-YLIDENE)-1-PROPENYL]-1,3-DIETHYL-3H-BENZIMIDAZOL-1-IUM IODIDE
  • BENZIMIDAZOLIUM, 5,6-DICHLORO-2-[3-(5,6-DICHLORO-1,3-DIETHYL-2-BENZIMIDAZOLINYLIDENE)PROPENYL]-1,3-DIETHYL-, IODIDE
  • BENZIMIDAZOLOCARBOCYANINE IODIDE, 5,5',6,6'-TETRACHLORO-1,1',3,3'-TETRAETHYL-
  • BIS(5,6-DICHLORO-1,3-DIETHYL-2-BENZIMIDAZOLE)TRIMETHINECYANINE IODIDE
  • IMIDACARBOCYANINE IODIDE, 1,1',3,3'-TETRAETHYL-5,5',6,6'-TETRACHLORO-
  • JC-1 IODIDE
  • CBIC2
  • CBIC2(3)
  • D 383
  • D 383 (DYE)
  • NK 1420
  • 5,5’,6,6’-tetrachloro-1,1’,3,3’-tetraethylbenzimidazolylcarbocyanineiodide(jc-1
  • (E)-5,6-Dichloro-2-(3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)prop
  • CBIC2(3) 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide
  • 3' - tetraethylbenzimidazolylcarbocyanine iodide
  • 6' - tetrachloro - 1
  • (E)-5,6-Dichloro-2-(3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)prop-1-en-1-yl)-1,3-diethyl-1H-benzo[d]imidazol-3-ium iodide
  • 47729-63-5
  • C25H27Cl4IN4
  • C25H27Cl4N4I
  • C25H27N4Cl4I
  • Lipophilic and Membrane Probes
  • Alphabetical
  • Fluorescent Indicators and Probes
  • Fluorescent Probes, Labels, Particles and Stains
  • BioChemical
  • Biochemicals and Reagents