SALICYLIDENE SALICYLHYDRAZIDE

Product Name: SALICYLIDENE SALICYLHYDRAZIDE
CAS No.: 3232-36-8
Chemical Name: SALICYLIDENE SALICYLHYDRAZIDE
Synonyms: SCS;NSC 87864;TIMTEC-BB SBB007781;SALICYLIDENE SALICYLHYDRAZONE;SALICYLIDENE SALICYLHYDRAZIDE;Salicylidenesalicylhydrazide,97%;SCS,Salicylidenesalicylhydrazide;N'-Salicylidenesalicylic hydrazide;Salicylidene salicylhydrazide (SCS);1-Salicylidene-2-salicyloylhydrazine
CBNumber: CB3169632
Molecular Formula: C14H12N2O3
Formula Weight: 256.26
MOL File: 3232-36-8.mol

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SALICYLIDENE SALICYLHYDRAZIDE Property

Melting point:: 280-284°C
storage temp.: Store at RT
solubility: DMSO: ~20 mg/mL
form: solid
color: off-white
BRN: 2944701
CAS DataBase Reference: 3232-36-8(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazide (3232-36-8)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37
WGK Germany: 3
TSCA: Yes
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S924792
Product name: SALICYLIC (2-HYDROXYBENZYLIDENE)HYDRAZIDE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $143
Updated: 2025/07/31

Sigma-Aldrich

Product number: S924792
Product name: SALICYLIC (2-HYDROXYBENZYLIDENE)HYDRAZIDE
Purity: Aldrich
Packaging: 50mg
Price: $139
Updated: 2024/03/01

Tocris

Product number: 2143
Product name: SCS
Packaging: 50
Price: $125
Updated: 2021/12/16

TRC

Product number: S201425
Product name: SCS
Packaging: 5g
Price: $100
Updated: 2021/12/16

Usbiological

Product number: 256640
Product name: SCS
Packaging: 50mg
Price: $366
Updated: 2021/12/16

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SALICYLIDENE SALICYLHYDRAZIDE Chemical Properties,Usage,Production

Uses

SCS is a selective inhibitor of β1-containing GABAA receptors.

Definition

ChEBI: 2-hydroxy-N'-[(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]benzohydrazide is a member of salicylamides.

Biological Activity

Potent and selective partial inhibitor of β 1-containing GABA A receptors (IC 50 values are 4.5, 5.3 and 7.9 nM at α 2 β 1 γ 1 θ , α 2 β 1 γ 1 and α 2 β 1 γ 2s GABA A receptors respectively). May bind allosterically to a novel site on GABA A receptor.

in vivo

SCS (Salicylidene salicylhydrazide; 500-1000 mg/kg, i.p. or 800-1000 mg/kg, oral) produces abdominal constrictions in mice^[2].
SCS (10-75 mg/kg; i.p.; once) shows antinociceptive activity against tonic, phasic and Capsaicin (HY-10448) nociception in mice^[2].
SCS (10-75 mg/kg; i.p.; once) shows anti-inflammatory activity in mice^[2]. SCS (50 and 75 mg/kg; i.p.; once) shows antinociceptive activity against neuropathic nociception^[2].

Animal Model:	BALB/c mice; tonic, phasic and Capsaicin (HY-10448) nociception model^[2]
Dosage:	10, 25, 50, and 75 mg/kg
Administration:	IP, single dose
Result:	Produced a significant protection on tonic, phasic and capsaicin nociception in a dose-dependent manner.

Animal Model:	BALB/c mice, Oxaliplatin (HY-17371)-induced neuropathic nociception model^[2]
Dosage:	50 and 75 mg/kg
Administration:	IP, single dose
Result:	Significantly attenuated the paw withdrawal threshold changes associated with Oxaliplatin. Significantly increased the percent antinociception during 30-120 min.

SALICYLIDENE SALICYLHYDRAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SALICYLIDENE SALICYLHYDRAZIDE Suppliers

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View Lastest Price from SALICYLIDENE SALICYLHYDRAZIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: SALICYLIDENE SALICYLHYDRAZIDE 3232-36-8
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-10

3232-36-8, SALICYLIDENE SALICYLHYDRAZIDERelated Search:

SALICYLIDENE SALICYLHYDRAZIDE SALOR-INT L104957-1EA SALOR-INT L400270-1EA SALOR-INT L269360-1EA SALOR-INT L105899-1EA SALOR-INT L105902-1EA SALOR-INT L458163-1EA SALOR-INT L451347-1EA 3-HYDROXY-N'-[(1E)-(2-HYDROXYPHENYL)METHYLENE]-2-NAPHTHOHYDRAZIDE SALOR-INT L106313-1EA SALOR-INT L105120-1EA SALOR-INT L106062-1EA N'-[(E)-(5-BROMO-2-ETHOXYPHENYL)METHYLIDENE]-2-HYDROXYBENZENECARBOHYDRAZIDE SALOR-INT L104809-1EA SALOR-INT L483648-1EA 3-HYDROXY-N'-[(1E)-(2-HYDROXY-1-NAPHTHYL)METHYLENE]-2-NAPHTHOHYDRAZIDE N'-[(1E)-(5-BROMO-2-HYDROXYPHENYL)METHYLENE]-3-HYDROXY-2-NAPHTHOHYDRAZIDE SALOR-INT L463396-1EA

2-HYDROXYBENZYLIDENE SALICYLHYDRAZIDE

2-HYDROXYBENZYLIDENE 2-HYDROXYBENZHYDRAZIDE

2-hydroxy-benzoicaci[(2-hydroxyphenyl)methylene]hydrazide

(2-hydroxybenzylidene)salicylohydrazide

Salicylidenesalicylhydrazide,97%

2-Hydroxybenzylidene 2-hydroxybenzhydrazide, NSC 87864, SCS

SALICYLIDENE SALICYLHYDRAZIDE

SALICYLIDENE SALICYLHYDRAZONE

TIMTEC-BB SBB007781

SCS

NSC 87864

SALICYLIC (2-HYDROXYBENZYLIDENE)HYDRAZIDE

(2-Hydroxyphenyl)[2-(2-hydroxybenzylidene)hydrazono]methanol

1-(2-Hydroxybenzoyl)-2-(2-hydroxybenzylidene)hydrazine

1-Salicylidene-2-salicyloylhydrazine

1-Salicyloyl-2-salicylidenehydrazine

N'-(2-Hydroxybenzylidene)-2-hydroxybenzhydrazide

N'-Salicylidenesalicylic hydrazide

Benzoic acid, 2-hydroxy-, 2-[(2-hydroxyphenyl)methylene]hydrazide

SCS,Salicylidenesalicylhydrazide

2-hydroxy-N''-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]benzohydrazide

Salicylidene salicylhydrazide (SCS)

N-Salicylidene-N'-salicyloylhydrazine

2-Hydroxy-N'-(2-hydroxybenzylidene)benzohydrazide

3232-36-8

GABA and Glycine Receptor Modulators

Ion Channels

Ligand-Gated Ion Channels

Cell Signaling and Neuroscience

Cell Biology

BioChemical

GABA/Glycine receptor

Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes