4-[(6-chloropyridin-3-yl)carbonyl]morpholine
- Product Name
- 4-[(6-chloropyridin-3-yl)carbonyl]morpholine
- CAS No.
- 64614-49-9
- Chemical Name
- 4-[(6-chloropyridin-3-yl)carbonyl]morpholine
- Synonyms
- Albb-004234;(morpholino);(6-Chloropyridin-3-yl);4-(6-chloropyridine-3-carbonyl)morpholine;(6-chloropyridin-3-yl)(Morpholino)Methanone;4-[(6-chloropyridin-3-yl)carbonyl]morpholine;4-[(6-chloro-3-pyridinyl)carbonyl]morpholine;(6-chloro-3-pyridinyl)-(4-morpholinyl)methanone;Methanone, (6-chloro-3-pyridinyl)-4-morpholinyl-;(6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone
- CBNumber
- CB31745879
- Molecular Formula
- C10H11ClN2O2
- Formula Weight
- 226.66
- MOL File
- 64614-49-9.mol
4-[(6-chloropyridin-3-yl)carbonyl]morpholine Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CBR00221
- Product name
- 4-[(6-Chloro-3-pyridinyl)carbonyl]morpholine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $87.5
- Updated
- 2025/07/31
- Product number
- C596208
- Product name
- (6-Chloropyridin-3-yl)(morpholino)methanone
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C596208
- Product name
- (6-Chloropyridin-3-yl)(morpholino)methanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC115709
- Product name
- 4-[(6-Chloropyridin-3-yl)carbonyl]morpholine
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- FC115709
- Product name
- 4-[(6-Chloropyridin-3-yl)carbonyl]morpholine
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
4-[(6-chloropyridin-3-yl)carbonyl]morpholine Chemical Properties,Usage,Production
Synthesis
110-91-8
58757-38-3
64614-49-9
General procedure for the synthesis of (6-chloro-3-pyridine)-4-morpholinemethanone from 6-chloro-3-pyridinecarbonyl chloride and morpholine: To a solution of 6-chloro-3-pyridinecarbonyl chloride (0.540 g, 3.07 mmol) in methylene chloride (10 mL) was added sequentially morpholine (0.294 g, 1.1 eq.) and triethylamine (940 μL, 2.2 eq.). The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin-layer chromatography (TLC), and after confirming that 6-chloro-3-pyridinecarbonyl chloride was completely consumed and the mass spectrum showed the molecular ion peak (M+) of the target product, an aqueous post-treatment was performed. The crude product (6-chloro-3-pyridinyl)-4-morpholinemethanone obtained was directly used in the next step of the reaction without further purification. After aqueous treatment, 0.610 g of the crude product was obtained in 88% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 3, p. 689 - 693
[2] Patent: WO2004/46120, 2004, A2. Location in patent: Page 160
[3] Organic Process Research and Development, 2014, vol. 18, # 1, p. 228 - 238
[4] Patent: WO2004/56369, 2004, A1. Location in patent: Page/Page column 18
4-[(6-chloropyridin-3-yl)carbonyl]morpholine Preparation Products And Raw materials
Raw materials
Preparation Products
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