Bis(4-fluorophenyl)-methanone

Product Name: Bis(4-fluorophenyl)-methanone
CAS No.: 345-92-6
Chemical Name: Bis(4-fluorophenyl)-methanone
Synonyms: 4,4-DIFLUOROBENZOPHENONE;BDF;Difluorobenzophenone;4,4’-difluoro-benzophenon;BIS(4-FLUOROPHENYL) KETONE;Bis(4-fluorophenyl)-;4,4' -difluorophenone;p-Fluorophenyl ketone;-Difluorobenzophenone;LABOTEST-BB LT00159767
CBNumber: CB3179589
Molecular Formula: C13H8F2O
Formula Weight: 218.2
MOL File: 345-92-6.mol

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Bis(4-fluorophenyl)-methanone Property

Melting point:: 102-105 °C (lit.)
Boiling point:: 137°C (3 torr)
Density: 1.2543 (estimate)
vapor pressure: 0.005Pa at 20℃
Flash point:: 170-172°C/10mm
storage temp.: Sealed in dry,Room Temperature
solubility: Insoluble in water
form: Crystalline Powder
color: White to slightly yellow
Water Solubility: 8.757mg/L at 20℃
BRN: 516231
InChI: 1S/C13H8F2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8H
InChIKey: LSQARZALBDFYQZ-UHFFFAOYSA-N
SMILES: Fc1ccc(cc1)C(=O)c2ccc(F)cc2
LogP: 3.37 at 20℃
CAS DataBase Reference: 345-92-6(CAS DataBase Reference)
NIST Chemistry Reference: 4,4'-Difluorobenzophenone(345-92-6)
EPA Substance Registry System: 4,4'-Difluorobenzophenone (345-92-6)

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Safety

Hazard Codes: Xi,N,Xn
Risk Statements: 36/37/38-51/53-22
Safety Statements: 26-37/39-36-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
RTECS: DJ0685000
TSCA: TSCA listed
HazardClass: IRRITANT
HS Code: 29143990
Storage Class: 13 - Non Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Aquatic Chronic 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 115495
Product name: 4,4′-Difluorobenzophenone
Purity: 99%
Packaging: 25g
Price: $116
Updated: 2026/03/19

Sigma-Aldrich

Product number: PHR2117
Product name: 4,4′-Difluorobenzophenone
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 200mg
Price: $165
Updated: 2026/03/19

TCI Chemical

Product number: D1797
Product name: 4,4'-Difluorobenzophenone
Purity: >99.0%(GC)
Packaging: 25g
Price: $31
Updated: 2026/03/19

TCI Chemical

Product number: D1797
Product name: 4,4'-Difluorobenzophenone
Purity: >99.0%(GC)
Packaging: 100g
Price: $63
Updated: 2026/03/19

Sigma-Aldrich

Product number: 115495
Product name: 4,4′-Difluorobenzophenone
Purity: 99%
Packaging: 100g
Price: $245
Updated: 2026/03/19

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Bis(4-fluorophenyl)-methanone Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow crystalline powder

Uses

4,4′-Difluorobenzophenone has been used in the study of thermal stability, water uptake and proton conductivity of carboxylated, carboxylated/sulfonated, and crosslinked membranes.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 540, 1968 DOI: 10.1021/ja01004a087

General Description

4,4′-Difluorobenzophenone is typically used as a starting material for the preparation of polyetheretherketone (PEEK) polymer, a high-temperature thermoplastic, which finds wide use in dentistry as well as in automotive, oil industries, etc.

Synthesis

Mix 200g of fluorobenzene with 65g of anhydrous aluminum trichloride, cool to 0-5, add 100g of p-fluorotrichloromethylbenzene dropwise reaction for 20min, get 4,4'-difluorophenyl dichloromethane;

Add 4,4'-difluorophenyl dichloromethane to 600g of water mixing, heating To the azeotropic temperature at the same time recycling fluorobenzene 140g, reaction 5h, cooling to room temperature, filtration, drying to get light yellow solid crude 102g, using 200g methanol recrystallization, filtration, washing, drying, to get the melting point of 107-108 white crystals 92g, the purity of gas chromatography analysis of 99.9%, the yield is 90%. Detected by 1H-NMR: 7.28 (4H, t, hydrogen adjacent to the fluorine on the benzene ring); 7.81 (4H, m, hydrogen adjacent to the carbonyl on the benzene ring), which is consistent with the structure of 4,4'-difluorobenzophenone.

Bis(4-fluorophenyl)-methanone Preparation Products And Raw materials

Raw materials

Fluorobenzene

Preparation Products

(4-(4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YL)PHENYL)METHANOL

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Bis(4-fluorophenyl)-methanone Suppliers

Americas 1 Belgium 2 Canada 3 China 589 Europe 5 France 1 Germany 9 India 22 Italy 1 Japan 3 Slovakia 1 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 15 United States 52 USA 1 Global 708

SINO HIGH(CHINA)CO.,LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from Bis(4-fluorophenyl)-methanone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4, 4′-Difluorobenzophenone 345-92-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2025-06-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Bis(4-fluorophenyl)-methanone 345-92-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-25

RongNa Biotechnology Co.,Ltd

Product: 4,4′-difluorobenzophenone 345-92-6
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-03-26

345-92-6, Bis(4-fluorophenyl)-methanoneRelated Search:

3,4-DIMETHYLBENZENE-1-CARBONYL CHLORIDE Doxofylline Impurity 11 Vernakalant Impurity 1 ((3S,1'S,2'S)-Isomer) HCl Vernakalant-d6 HCl 4-ethenyl-1,2-dimethyl-benzene Vortioxetine Impurity 32 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-7,8-dinitro- 16-Hydroxy Capsaicin 3-METHOXYBENZALACETONE Diphenylmethane 2,4'-Difluorobenzophenone 3,4-Difluorobenzophenone 2,4-Difluorobenzophenone 3,3'-Difluorobenzophenone 2,6-DIFLUOROBENZOPHENONE 4-FLUORODIPHENYLMETHANE Benzophenone 4,4'-Difluorodiphenylmethane

Benzophenone, 4,4'-difluoro-

bis(4-fluorophenyl)-methanon

Bis(p-fluorophenyl) ketone

bis(p-fluorophenyl)ketone

Di-p-fluorophenyl ketone

di-p-fluorophenylketone

Methanone, bis(4-fluorophenyl)-

p,p’-difluorobenzophenone

p,p'-Difluorobenzophenone

4,4'-Difluorbenzophenone

DI(4-FLUOROPHENYL)METHANONE

LABOTEST-BB LT00159767

BIS-(4-FLUORO-PHENYL)-METHANONE

4,4'-Dddifluorobenzophenone

4,4'-Difluorobnzophenone

4,4'-Difluorobenzophenone/Bis(4-Fluorophenyl)Methanone

4,4'-Difluorobenzophenone, 98+%

4,4''-DIFLURO BENZOPHENONE

4,4'-Difluorobenzophenone99%

Flunarizine Impurity 10

4'-Difluorobenzophenone

(4,4-difluoro-1-cyclohexa-1,5-dienyl)-phenylmethanone

Bis(4-fluorophenyl)-methanone 345-92-6

4,4''-DIFLUOROBENZOPHENONEFLUNARIZINE

4, 4 - two fluorine diphenyl ketone

Difluorobenzophenone

4,4'- twofluorine twoBenzophenone

4,4'-Difluorobenzophenone, 97+%

1,1'-Carbonylbis(4-fluorobenzene)

4,4'-Carbonylbis(1-fluorobenzene)

4,4'-Carbonylbis(fluorobenzene)

Bis(4-fluorophenyl)-

4.4'-Difluarobenzophonone

4,4'-Difluorobenzophenone≥ 99% (GC)

1,1-di(p-fluorophenyl)-ketone

4,4'-Difluorobenzophenone, 99%, for synthesis

4,4'-Difluorobenzophenone &gt

4,4' -difluorophenone

High Quality 4, 4′-Difluorobenzophenone

p-Fluorophenyl ketone

-Difluorobenzophenone

Benzophenone,4,4'-difluoro-Chemicalbook

4,4'-Difluorobenzophenone

4,4'-difluoro-benzophenon

4,4′-Difluorobenzophenone, CAS 345-92-6

4,4’-difluoro-benzophenon

4,4-DIFLUOROBENZOPHENONE

BIS(4-FLUOROPHENYL) KETONE

BDF

345-92-6

3450-92-6

C13H8F2O

Benzophenones (for High-Performance Polymer Research)

Reagent for High-Performance Polymer Research

C13 to C14

Carbonyl Compounds

Building Blocks

Organic Building Blocks