Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester
- Product Name
- Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester
- CAS No.
- 944805-17-8
- Chemical Name
- Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester
- Synonyms
- 2-(Boc-amino)-4-bromo-5-formylthiazole;tert-Butyl (4-broMo-5-forMylthiazol-2-yl)carbaMate;2-Methyl-2-propanyl (4-bromo-5-formyl-1,3-thiazol-2-yl)carbamate;Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB31858872
- Molecular Formula
- C9H11BrN2O3S
- Formula Weight
- 307.16
- MOL File
- 944805-17-8.mol
Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester Property
- Density
- 1.625±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.22±0.70(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 7932DF
- Product name
- Tert-Butyl(4-bromo-5-formylthiazol-2-yl)carbamate
- Packaging
- 100mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- A213647
- Product name
- tert-Butyl(4-bromo-5-formylthiazol-2-yl)carbamate
- Purity
- 97%
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CD11006945
- Product name
- tert-Butyl(4-bromo-5-formylthiazol-2-yl)carbamate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $237
- Updated
- 2021/12/16
- Product number
- 944805178
- Product name
- tert-Butyl(4-bromo-5-formylthiazol-2-yl)carbamate
- Packaging
- 250mg
- Price
- $296.48
- Updated
- 2021/12/16
- Product number
- CD11006945
- Product name
- tert-Butyl(4-bromo-5-formylthiazol-2-yl)carbamate
- Purity
- 97%
- Packaging
- 1g
- Price
- $591
- Updated
- 2021/12/16
Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester Chemical Properties,Usage,Production
Synthesis
68-12-2
944805-17-8
A mixed solution of diisopropylamine (8.28 mL, 59.1 mmol) and 100 mL of tetrahydrofuran (THF, 1.29 g, 17.9 mmol) was added to a 500 mL round bottom flask. The reaction system was cooled to 0 °C, followed by the slow addition of n-butyllithium (2.5 M hexane solution, 23.6 mL, 59.1 mmol). The reaction mixture was stirred at 0 °C for about 20 min, followed by the slow addition of tert-butyl 5-bromothiazol-2-ylcarbamate (5.00 g, 17.9 mmol) in THF solution. After continued stirring for 30 min, the reaction was quenched by dropwise addition of N,N-dimethylformamide (DMF, 4.58 mL, 59.1 mmol). The reaction mixture was stirred at room temperature for about 12 hours. Upon completion of the reaction, the mixture was partitioned between water and ethyl acetate (EtOAc) and the aqueous layer was extracted with ethyl acetate (2 x 100 mL). The combined organic layers were washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography using a 330 g Redi-Sep? pre-populated silica gel column eluting with a gradient of 5% to 25% ethyl acetate in hexane solution to afford tert-butyl 4-bromo-5-formylthiazol-2-ylcarbamate (3.31 g, 60.2% yield).
References
[1] Patent: US2007/173506, 2007, A1. Location in patent: Page/Page column 79
Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester Preparation Products And Raw materials
Raw materials
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