3(2H)-Benzofuranone, 4-fluoro-
- Product Name
- 3(2H)-Benzofuranone, 4-fluoro-
- CAS No.
- 911826-36-3
- Chemical Name
- 3(2H)-Benzofuranone, 4-fluoro-
- Synonyms
- 4-fluoro-1-benzofuran-3-one;4-Fluorobenzofuran-3(2H)-one;3(2H)-Benzofuranone, 4-fluoro-;4-fluoro-2,3-dihydro-1-benzofuran-3-one
- CBNumber
- CB31862424
- Molecular Formula
- C8H5FO2
- Formula Weight
- 152.12
- MOL File
- 911826-36-3.mol
3(2H)-Benzofuranone, 4-fluoro- Property
- Boiling point:
- 259.6±40.0 °C(Predicted)
- Density
- 1.379±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C8H5FO2/c9-5-2-1-3-7-8(5)6(10)4-11-7/h1-3H,4H2
- InChIKey
- XNMLJZYMKUNKTL-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC(F)=C2C(=O)C1
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F870020
- Product name
- 4-Fluorobenzofuran-3(2H)-one
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F870020
- Product name
- 4-Fluorobenzofuran-3(2H)-one
- Packaging
- 100mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- HCH0366325
- Product name
- 4-FLUOROBENZOFURAN-3(2H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.99
- Updated
- 2021/12/16
- Product number
- 5225AC
- Product name
- 4-Fluorobenzofuran-3(2H)-one
- Packaging
- 100mg
- Price
- $242
- Updated
- 2021/12/16
- Product number
- PC6226
- Product name
- 4-Fluorobenzo[b]furan-3(2H)-one
- Packaging
- 250mg
- Price
- $244
- Updated
- 2021/12/16
3(2H)-Benzofuranone, 4-fluoro- Chemical Properties,Usage,Production
Synthesis
500912-12-9
18107-18-1
911826-36-3
The general procedure for the synthesis of 4-fluorobenzofuran-3(2H)-ones from 2-fluoro-6-methoxybenzoyl chloride and trimethylsilylated diazomethane was as follows: 3.7 mL of a 2.0 M solution of trimethylsilylated diazomethane ether (yellow) was slowly added to a reaction vial containing 0.57 g (3.0 mmol) of 2-fluoro-6-methoxybenzoyl chloride under stirring conditions. After 3 hours of reaction, the solvent was removed by evaporation. The yellow residue obtained was dissolved in 3 mL of acetic acid (the reaction was exothermic and gaseous, requiring cooling of the reaction vial in a water bath for 1 min), followed by stirring at room temperature for 15 min. After completion of the reaction, the solvent was removed by vacuum distillation, and the red residue was dissolved in 2 mL of dichloromethane, washed sequentially with water and brine, and finally dried with anhydrous sodium sulfate. The crude product was purified by column chromatography (the eluent was a hexane solution of 10% ethyl acetate) to give 0.24 g (53% yield) of 4-fluorobenzofuran-3(2H)-one as a white solid.1H NMR (300 MHz, CDCl3): δ 7.58 (m, 1H), 6.92 (br d, 1H), 6.71 (t, 1H), 4.65 (s, 2H). 2H).
References
[1] Patent: US2008/119496, 2008, A1. Location in patent: Page/Page column 34
3(2H)-Benzofuranone, 4-fluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
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