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3-Pyridinol, 4-methyl-2-nitro-

Product Name
3-Pyridinol, 4-methyl-2-nitro-
CAS No.
15128-89-9
Chemical Name
3-Pyridinol, 4-methyl-2-nitro-
Synonyms
4-Methyl-2-nitropyridin-3-ol;4-METHYL-2-NITRO-3-PYRIDINOL;3-Pyridinol, 4-methyl-2-nitro-;2-nitro-3-hydroxy-4-methylpyridine;3-Hydroxy-4-methyl-2-nitropyridine;3-Pyridinol, 4-methyl-2-nitro- ISO 9001:2015 REACH
CBNumber
CB31863517
Molecular Formula
C6H6N2O3
Formula Weight
154.12
MOL File
15128-89-9.mol
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3-Pyridinol, 4-methyl-2-nitro- Property

Boiling point:
389.8±37.0 °C(Predicted)
Density 
1.411±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
0.95±0.30(Predicted)
Appearance
Light yellow to yellow Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M341203
Product name
4-Methyl-2-nitropyridin-3-ol
Packaging
100mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0102095
Product name
4-Methyl-2-nitropyridin-3-ol
Purity
≥97.0%
Packaging
100mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-0102095
Product name
4-Methyl-2-nitropyridin-3-ol
Purity
≥97.0%
Packaging
250mg
Price
$115
Updated
2021/12/16
AK Scientific
Product number
X2104
Product name
3-Hydroxy-4-methyl-2-nitropyridine
Packaging
100mg
Price
$145
Updated
2021/12/16
AK Scientific
Product number
X2104
Product name
3-Hydroxy-4-methyl-2-nitropyridine
Packaging
250mg
Price
$211
Updated
2021/12/16
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3-Pyridinol, 4-methyl-2-nitro- Chemical Properties,Usage,Production

Synthesis

1121-19-3

15128-89-9

The general procedure for the synthesis of 3-hydroxy-4-methyl-2-nitropyridine from 3-hydroxy-4-methylpyridine was as follows: 3-hydroxy-4-methylpyridine (59 g, 545 mmol) was added in batches to concentrated sulfuric acid (290 mL) under the cooling condition of an ice-water bath to ensure that the temperature of the reaction was maintained below 40°C. The reaction was carried out in the following manner. Subsequently, a mixture of pre-chilled fuming nitric acid (25.5 mL, 600 mmol) and concentrated sulfuric acid (58 mL) was slowly added dropwise to the reaction system over about 45 min at 0 °C, controlling the reaction temperature to not exceed 20 °C. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. After completion of the reaction, the mixture was slowly poured into an ice-water mixture (1.5 L). The pH of the mixture was carefully adjusted with ammonium hydroxide to 1-2. The resulting precipitate was collected by filtration and dried to afford the target product 3-hydroxy-4-methyl-2-nitropyridine (69.5 g, 83% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, DMSO-d6): δH 10.40 (s, 1H), 7.93 (d, J=4.5 Hz, 1H), 7.57 (d, J=4.5 Hz, 1H), 2.32 (s, 3H).

References

[1] Patent: WO2016/198400, 2016, A1. Location in patent: Page/Page column 63
[2] Patent: WO2011/59839, 2011, A1. Location in patent: Page/Page column 85-86
[3] Heterocycles, 1994, vol. 38, # 3, p. 529 - 540
[4] Patent: WO2007/77961, 2007, A2. Location in patent: Page/Page column 341
[5] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3636 - 3643

3-Pyridinol, 4-methyl-2-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Pyridinol, 4-methyl-2-nitro- Suppliers

Accela ChemBio Co.,Ltd.
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China
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Synchem OHG
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Yancheng KangdiSen Pharmaceutical Co., Ltd.
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Shanghai YuanYe Biotechnology Co., Ltd.
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Amadis Chemical Company Limited
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View Lastest Price from 3-Pyridinol, 4-methyl-2-nitro- manufacturers

Dideu Industries Group Limited
Product
3-Pyridinol, 4-methyl-2-nitro- 15128-89-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-28

15128-89-9, 3-Pyridinol, 4-methyl-2-nitro-Related Search:


  • 4-METHYL-2-NITRO-3-PYRIDINOL
  • 4-Methyl-2-nitropyridin-3-ol
  • 3-Pyridinol, 4-methyl-2-nitro-
  • 3-Hydroxy-4-methyl-2-nitropyridine
  • 2-nitro-3-hydroxy-4-methylpyridine
  • 3-Pyridinol, 4-methyl-2-nitro- ISO 9001:2015 REACH
  • 15128-89-9