3-Pyridinol, 4-methyl-2-nitro-
- Product Name
- 3-Pyridinol, 4-methyl-2-nitro-
- CAS No.
- 15128-89-9
- Chemical Name
- 3-Pyridinol, 4-methyl-2-nitro-
- Synonyms
- 4-Methyl-2-nitropyridin-3-ol;4-METHYL-2-NITRO-3-PYRIDINOL;3-Pyridinol, 4-methyl-2-nitro-;2-nitro-3-hydroxy-4-methylpyridine;3-Hydroxy-4-methyl-2-nitropyridine;3-Pyridinol, 4-methyl-2-nitro- ISO 9001:2015 REACH
- CBNumber
- CB31863517
- Molecular Formula
- C6H6N2O3
- Formula Weight
- 154.12
- MOL File
- 15128-89-9.mol
3-Pyridinol, 4-methyl-2-nitro- Property
- Boiling point:
- 389.8±37.0 °C(Predicted)
- Density
- 1.411±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 0.95±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- M341203
- Product name
- 4-Methyl-2-nitropyridin-3-ol
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0102095
- Product name
- 4-Methyl-2-nitropyridin-3-ol
- Purity
- ≥97.0%
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-0102095
- Product name
- 4-Methyl-2-nitropyridin-3-ol
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- X2104
- Product name
- 3-Hydroxy-4-methyl-2-nitropyridine
- Packaging
- 100mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- X2104
- Product name
- 3-Hydroxy-4-methyl-2-nitropyridine
- Packaging
- 250mg
- Price
- $211
- Updated
- 2021/12/16
3-Pyridinol, 4-methyl-2-nitro- Chemical Properties,Usage,Production
Synthesis
1121-19-3
15128-89-9
The general procedure for the synthesis of 3-hydroxy-4-methyl-2-nitropyridine from 3-hydroxy-4-methylpyridine was as follows: 3-hydroxy-4-methylpyridine (59 g, 545 mmol) was added in batches to concentrated sulfuric acid (290 mL) under the cooling condition of an ice-water bath to ensure that the temperature of the reaction was maintained below 40°C. The reaction was carried out in the following manner. Subsequently, a mixture of pre-chilled fuming nitric acid (25.5 mL, 600 mmol) and concentrated sulfuric acid (58 mL) was slowly added dropwise to the reaction system over about 45 min at 0 °C, controlling the reaction temperature to not exceed 20 °C. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. After completion of the reaction, the mixture was slowly poured into an ice-water mixture (1.5 L). The pH of the mixture was carefully adjusted with ammonium hydroxide to 1-2. The resulting precipitate was collected by filtration and dried to afford the target product 3-hydroxy-4-methyl-2-nitropyridine (69.5 g, 83% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, DMSO-d6): δH 10.40 (s, 1H), 7.93 (d, J=4.5 Hz, 1H), 7.57 (d, J=4.5 Hz, 1H), 2.32 (s, 3H).
References
[1] Patent: WO2016/198400, 2016, A1. Location in patent: Page/Page column 63
[2] Patent: WO2011/59839, 2011, A1. Location in patent: Page/Page column 85-86
[3] Heterocycles, 1994, vol. 38, # 3, p. 529 - 540
[4] Patent: WO2007/77961, 2007, A2. Location in patent: Page/Page column 341
[5] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3636 - 3643
3-Pyridinol, 4-methyl-2-nitro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Pyridinol, 4-methyl-2-nitro- manufacturers
- Product
- 3-Pyridinol, 4-methyl-2-nitro- 15128-89-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-28