Benzaldehyde, 4-chloro-3-hydroxy-
Uses- Product Name
- Benzaldehyde, 4-chloro-3-hydroxy-
- CAS No.
- 56962-12-0
- Chemical Name
- Benzaldehyde, 4-chloro-3-hydroxy-
- Synonyms
- 3-hydroxy-4-chlorobenzaldehyde;Benzaldehyde, 4-chloro-3-hydroxy-;Benzaldehyde, 4-chloro-3-hydroxy- ISO 9001：2015 REACH
- CBNumber
- CB31868158
- Molecular Formula
- C7H5ClO2
- Formula Weight
- 156.57
- MOL File
- 56962-12-0.mol
Benzaldehyde, 4-chloro-3-hydroxy- Property
- Melting point:
- 119-122°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Yellow to brown Solid
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C585830
- Product name
- 4-Chloro-3-hydroxybenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC140156
- Product name
- 4-Chloro-3-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- J94281
- Product name
- 4-Chloro-3-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 093472
- Product name
- 4-Chloro-3-hydroxybenzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- FC140156
- Product name
- 4-Chloro-3-hydroxybenzaldehyde
- Packaging
- 2g
- Price
- $180
- Updated
- 2021/12/16
Benzaldehyde, 4-chloro-3-hydroxy- Chemical Properties,Usage,Production
Uses
4-Chloro-3-hydroxybenzaldehyde can be used as a pharmaceutical synthesis intermediate.
Synthesis
100-83-4
7310-94-3
56962-12-0
3-Hydroxybenzaldehyde (1 g, 10 mmol) was used as starting material and dissolved in acetonitrile (50 mL). To this solution, p-toluenesulfonic acid was added in batches at room temperature and after stirring for 5 minutes, N-chlorosuccinimide (NCS, 1.33 g, 10 mmol) was added. The reaction mixture was continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with aqueous sodium thiosulfate and subsequently diluted with ethyl acetate and brine. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with petroleum ether/ethyl acetate (10:1 to 5:1) as eluent to afford 2-chloro-5-hydroxybenzaldehyde (340 mg, 21.7% yield, Intermediate 28a) and 4-chloro-3-hydroxybenzaldehyde (310 mg, 19.7% yield, Intermediate 28b) as yellow solids, respectively. 2-chloro-5-hydroxybenzaldehyde's 1H-NMR (CDCl3) data: δ 10.43 (s, 1H), 7.54-7.56 (d, 1H), 7.30-7.37 (m, 2H). 4-Chloro-3-hydroxybenzaldehyde 1H-NMR (CDCl3) data: δ 10.43 (s, 1H), 7.40 (d, 1H), 7.33 (d, 1H), 7.06- 7.09 (dd, 1H).
References
[1] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 391
[2] Patent: US2014/275528, 2014, A1. Location in patent: Paragraph 0322; 0323
Benzaldehyde, 4-chloro-3-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzaldehyde, 4-chloro-3-hydroxy- manufacturers
- Product
- Benzaldehyde, 4-chloro-3-hydroxy- 56962-12-0
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10