ChemicalBook > CAS DataBase List > 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid

2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid

Product Name
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
CAS No.
116371-67-6
Chemical Name
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
Synonyms
Gemcitabine Impurity 37;Gemcitabine Monophosphate;Gemcitabine-5′,-monophosphate;Gemcitibine monophosphate formate salt;Gemcitabine Monophosphate Formate Salt;Gemcitabine-5'-monophosphate Free acid;2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid;5'-Cytidylic acid, 2'-deoxy-2',2'-difluoro-;2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate;2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid ForMate
CBNumber
CB31873080
Molecular Formula
C9H12F2N3O7P
Formula Weight
343.18
MOL File
116371-67-6.mol
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2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Property

Melting point:
151-153?C
Boiling point:
618.3±65.0 °C(Predicted)
Density 
2.09
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
DMSO (Slightly), Water (Slightly)
form 
Solid
pka
1.86±0.10(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
G305005
Product name
GemcitabineMonophosphate
Packaging
1mg
Price
$120
Updated
2021/12/16
TRC
Product number
G305005
Product name
GemcitabineMonophosphate
Packaging
5mg
Price
$330
Updated
2021/12/16
Usbiological
Product number
296171
Product name
Gemcitabine Monophosphate, Formate salt
Packaging
5mg
Price
$708
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000579
Product name
GEMCITABINE MONOPHOSPHATE
Purity
95.00%
Packaging
1MG
Price
$750.75
Updated
2021/12/16
Biosynth Carbosynth
Product number
NG16551
Product name
2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate formate salt
Packaging
25mg
Price
$800
Updated
2021/12/16
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2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.

Uses

Gemcitabine derivative. An antineoplastic agent

in vivo

Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis[1].

Animal Model:Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1]
Dosage:19.5 mg/kg, every other day, four injections
Administration:Intravenous injection (i.v.)
Result:Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis.

2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Suppliers

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116371-67-6, 2'-Deoxy-2',2'-difluoro-5'-cytidylic AcidRelated Search:

Gemcitabine

  • 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
  • Gemcitabine Monophosphate
  • 2',2'-Difluoro-2'-deoxycytidine 5'-phosphoric acid
  • 2',2'-Difluoro-2'-deoxycytidine-5'-phosphoric acid
  • Gemcitabine Monophosphate Formate Salt
  • 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid ForMate
  • GeMcitabine Monophosphate disodiuM salt Monohydrate
  • 2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate formate salt
  • Gemcitibine monophosphate formate salt
  • 2'-Deoxy-2',2'-difluorocytidine monophosphate formate salt
  • 5'-Cytidylic acid, 2'-deoxy-2',2'-difluoro-
  • ((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
  • Gemcitabine-5'-monophosphate Free acid
  • Gemcitabine Impurity 37
  • Gemcitabine-5&#8242,-monophosphate
  • 2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate
  • 116371-67-6
  • C9H12F2N3O7P
  • C9H12F2N3O7P25
  • C10H14F2N3O9P
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Phosphorylating and Phosphitylating Agents
  • Bases & Related Reagents
  • Nucleotides