2,4-Bis(isopropylamino)-6-chloro-1,3,5-triazine Property

Melting point:

212-214°C

Boiling point:

368.7°C (rough estimate)

Density 

1.162

vapor pressure 

0Pa at 25℃

refractive index 

1.6110 (estimate)

Flash point:

11 °C

storage temp. 

APPROX 4°C

solubility 

Chloroform (Heated), DMSO (Slightly), Methanol (Slightly)

pka

2.28±0.10(Predicted)

Water Solubility 

8.6mg/L(22 ºC)

Merck 

13,7904

BRN 

747081

LogP

3.01 at 25℃ and pH7.1

CAS DataBase Reference

139-40-2(CAS DataBase Reference)

NIST Chemistry Reference

1,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-bis(1-methylethyl)-(139-40-2)

EPA Substance Registry System

Propazine (139-40-2)

Safety

Hazard Codes 

Xn;N,N,Xn,T,F

Risk Statements 

40-50/53-39/23/24/25-23/24/25-11

Safety Statements 

36/37-60-61-45-24-16-7

RIDADR 

UN 3077

WGK Germany 

3

RTECS 

XY5300000

HazardClass 

9

PackingGroup 

III

HS Code 

29336990

Hazardous Substances Data

139-40-2(Hazardous Substances Data)

Toxicity

LD50 orally in rats: >5000 mg/kg (Bailey, White)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

2,4-Bis(isopropylamino)-6-chloro-1,3,5-triazine Chemical Properties,Usage,Production

Chemical Properties

2,4-Bis(isopropylamino)-6-chloro-1,3,5-triazine is a colorless crystalline solid or powder.

Uses

2,4-Bis(isopropylamino)-6-chloro-1,3,5-triazine is used to control annual grasses and broad-leaved weeds in milo and sweet sorghum.

Uses

Herbicide.

Definition

Generic name for a preemergence herbicide containing 80% 2-chloro- 4,6-bis(isopropylamino)-s-triazine.

Agricultural Uses

Herbicide: Atrazine, simazine, and propazine and their common chlorinated degradates have a common mechanism of toxicity. They have similar applications. Propazine is used for control of broadleaf weeds and annual grasses in sweet sorghum. It is applied as a spray at the time of planting or immediately following planting, but prior to weed or sorghum emergence. It is also used as a post-emergence selective herbicide on carrots, celery and fennel. Not approved for use in EU countries. Some formulations are U.S. EPA restricted Use Pesticides (RUPs).

Trade name

GEIGY® 30,028; GESAMIL®; MAXX90®; MILOCEP®; MILOGARD®[C]; MILO-PRO®; PLANTULIN®; PRIMATOL P®; PROPAZIN®; PROPINEX®; PROZINEX®

Safety Profile

Moderately toxic by ingestion. Moderate eye irritation. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx and Cl-.

Potential Exposure

A potential danger to those involved in the manufacture, formulation and application of this tri- azine pre-emergence selective herbicide used to control annual broadleaf weeds and grasses.

Carcinogenicity

Oral gavage of 46.4 mg/kg to two strains of mice from 7 through 28 days of age, followed by feeding of 102 ppm for up to 18 months, produced no increase in tumors. Subcutaneous injection of a single 1000 mg/kg dose in mice of the same two strains that were observed for 18 months produced no carcinogenic response. Rats were given 0, 3, 100, or 1000 ppm of propazine in the diet for 2 years. At 1000 ppm, there was a significant decrease in body weight in both sexes and an increase in mammary tumors in females.

Environmental Fate

Soil. Undergoes microbial degradation in soil forming hydroxypropazine (Harris, 1967). Dealkylation of both substituted amino groups is presumably followed by ring opening and decomposition (Hartley and Kidd, 1987). Under laboratory conditions, the half-lives of propazine in a Hatzenbühl soil (pH 4.8) and Neuhofen soil (pH 6.5) at 22°C were 62 and 127 days, respectively (Burkhard and Guth, 1981).
Groundwater. According to the U.S. EPA (1986) propazine has a high potential to leach to groundwater.
Photolytic. Irradiation of propazine in methanol afforded prometone (2-methoxy-4,6- bis(isopropylamino-s-triazine). Photodegradation of propazine in methanol did not occur when irradiated at wavelengths >300 nm (Pape and Zabik, 1970).
Chemical/Physical. In aqueous solutions, propazine is converted exclusively to hydroxypropazine (2-hydroxy-4,6-bisisopropylamino)-s-triazine by UV light (λ = 253.7 nm) (Pape and Zabik, 1970). In acidic aqueous soil-free systems, propazine hydrolysis is pH dependent and follows first-order kinetics. At 23.5°C, the estimated hydrolysis half-lives at pH 2.0, 3.0, 4.0 and 5.0 are 9, 36, 141 and 550 days, respectively. The rate of hydrolysis was also found to increase and decrease in the presence of organic matter and calcium salts, respectively (Nearpass, 1972).

Shipping

UN2763 Triazine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.