ChemicalBook > CAS DataBase List > L-744,832

L-744,832

Product Name
L-744,832
CAS No.
1177806-11-9
Chemical Name
L-744,832
Synonyms
L-744832;L-744,832;L-744,832 Dihydrochloride;L-744,832 - CAS 1177806-11-9 - Calbiochem;(2S)-[(2S)-[(2R)-AMINO-3-MERCAPTO]-PROPYLAMINO-(3S)-METHYL]PENTYLOXY-3-PHENYLPROPIONYL-METHIONINE SULFONE ISOPROPYL ESTER BIS HYDRCHLORIDE;(2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride,
CBNumber
CB3188792
Molecular Formula
C26H47Cl2N3O6S2
Formula Weight
632.7
MOL File
Mol file
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L-744,832 Property

Melting point:
165-168°C
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
White solid
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
422720
Product name
L-744,832 - CAS 1177806-11-9 - Calbiochem
Packaging
5mg
Price
$259
Updated
2022/05/15
Usbiological
Product number
L0150
Product name
L-744832
Packaging
5mg
Price
$496
Updated
2021/12/16
TRC
Product number
L744832
Product name
L-744832
Packaging
1mg
Price
$140
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11427
Product name
L-744832
Packaging
5mg
Price
$860
Updated
2021/12/16
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L-744,832 Chemical Properties,Usage,Production

Chemical Properties

L-744,832 is White Cyrstalline Solid

Uses

L-744,832 is ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic

Uses

Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.

General Description

A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.

Biochem/physiol Actions

Cell permeable: yes

L-744,832 Preparation Products And Raw materials

Raw materials

Preparation Products

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1177806-11-9, L-744,832Related Search:


  • (2S)-[(2S)-[(2R)-AMINO-3-MERCAPTO]-PROPYLAMINO-(3S)-METHYL]PENTYLOXY-3-PHENYLPROPIONYL-METHIONINE SULFONE ISOPROPYL ESTER BIS HYDRCHLORIDE
  • L-744832
  • (2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride,
  • L-744,832 Dihydrochloride
  • L-744,832
  • L-744,832 - CAS 1177806-11-9 - Calbiochem
  • 1177806-11-9
  • Inhibitors