3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
- Product Name
- 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS No.
- 24922-01-8
- Chemical Name
- 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
- Synonyms
- ETHYL 3-CYCLOBUTYL-3-OXOPROPANOATE;CYCLOBUTANEPROPANOICACID, B-OXO-, ETHYL ESTER;3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER;Cyclobutanepropanoic acid, β-oxo-, ethyl ester
- CBNumber
- CB3191246
- Molecular Formula
- C9H14O3
- Formula Weight
- 170.21
- MOL File
- 24922-01-8.mol
3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER Property
- Boiling point:
- 112-115 °C(Press: 19 Torr)
- Density
- 1.096±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.51±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- E926333
- Product name
- Ethyl3-cyclobutyl-3-oxopropanoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 449093
- Product name
- Ethyl 3-cyclobutyl-3-oxopropanoate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 1929AB
- Product name
- Ethyl3-cyclobutyl-3-oxopropanoate
- Packaging
- 25g
- Price
- $784
- Updated
- 2021/12/16
- Product number
- CHM0129382
- Product name
- ETHYL-3-CYCLOBUTYL-3-OXOPROPANOATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1988.91
- Updated
- 2021/12/16
- Product number
- 2229-1-75
- Product name
- Ethyl 3-cyclobutyl-3-oxopropanoate
- Packaging
- 25g
- Price
- $2960
- Updated
- 2021/12/16
3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
6148-64-7
5006-22-4
24922-01-8
The general procedure for the synthesis of ethyl 3-cyclobutyl-3-oxopropanoate from monoethyl malonate potassium salt and cyclobutanecarbonyl chloride was as follows: potassium 3-ethoxy-3-oxopropanoate (60.3 g, 354.25 mmol) was suspended in acetonitrile (600 mL) under the protection of argon gas and cooled to 10 °C. Subsequently, triethylamine (75 mL, 540 mmol) and magnesium chloride (40.2 g, 421.72 mmol) were added sequentially, and the reaction temperature was controlled not to exceed 25 °C. The resulting thick white suspension was stirred at room temperature for 2.5 hours in an argon atmosphere. After that, the reaction mixture was cooled to 0-5 °C again and cyclobutanecarbonyl chloride (19.25 mL, 167 mmol) was added slowly dropwise for a controlled period of 1 hour. After the dropwise addition, the reaction mixture was allowed to gradually warm up to room temperature and continued stirring for 18 hours. After completion of the reaction, the solvent was removed by evaporation. The residue was dissolved in ethyl acetate (700 mL) and adjusted to an aqueous phase pH=5 with 2M hydrochloric acid (~400 mL) to ensure that all substances were dissolved. The organic phase was separated and washed sequentially with 2M hydrochloric acid (200 mL), saturated aqueous sodium bicarbonate (2 x 200 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to afford ethyl 3-cyclobutyl-3-oxopropionate as a light yellow oil (28.0 g, 98% yield). The structure of the product was confirmed by 1H NMR (400.132 MHz, CDCl3): δ 1.28 (3H, t), 1.80-1.89 (1H, m), 1.91-2.05 (1H, m), 2.12-2.34 (4H, m), 3.39 (2H, s), 3.34-3.42 (1H, m), 4.19 (2H, q).
References
[1] Patent: WO2011/114148, 2011, A1. Location in patent: Page/Page column 81
3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER manufacturers
- Product
- 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER 24922-01-8
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g； 1kg; 25kg
- Release date
- 2020-01-10
- Product
- 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER 24922-01-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20